_EC Pappalysin-1. 0 PDB entries  
EC 3.-.-.- Hydrolases. [21,435 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,954 PDB entries]
EC 3.4.24.- Metalloendopeptidases. [628 PDB entries]
EC Pappalysin-1. [-]    

Reaction: Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143-Ser-|-Lys-144 bond in IGFBP-5.
Other name(s): Insulin-like growth factor binding protein-4 protease. Pregnancy-associated plasma protein-A.
Cofactor(s): Zn(2+).
Comments: Circulates in human pregnancy mainly as a complex with the proform of eosinophil major basic protein, which acts as an inhibitor of the peptidase. The rate of hydrolysis of IGFBP-4 is increased about 20-fold by the presence of insulin-like growth factor (IGF), whereas that of IGFBP-5 is decreased about two-fold. Belongs to peptidase family M43.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.