_EC 3.4.24.74 Fragilysin. 0 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,846 PDB entries]
EC 3.4.24.- Metalloendopeptidases. [610 PDB entries]
EC 3.4.24.74 Fragilysin. [-]    

Reaction: Broad proteolytic specificity, bonds hydrolyzed includes -Gly-|-Leu-, -Met-|-Leu-, -Phe-|-Leu-, -Cys-|-Leu-, -Leu-|-Gly-.
Other name(s): Bacteroides fragilis enterotoxin.
Cofactor(s): Zn(2+).
Comments: Thought to be a cause of diarrhea. Hydrolyzes extracellular matrix proteins, and disrupts tight junctions of intstinal cells. Also degrades intracellular, cytoskeletal proteins actin, myosin and others. Belongs to peptidase family M10.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.3.4.24.74