_EC 3.4.24.69 Bontoxilysin. 99 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.24.- Metalloendopeptidases. [610 PDB entries]
EC 3.4.24.69 Bontoxilysin. [99 PDB entries]    
1e1h

Reaction: Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
Other name(s): Botulinum neurotoxin.
Cofactor(s): Zn(2+).
Comments: Belongs to peptidase family M27.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 99 PDB entries in enzyme class E.C.3.4.24.69

  PDB code Protein
1e1h
Crystal structure of recombinant botulinum neurotoxin type a light chain, self-inhibiting zn endopeptidase.
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: kyoto-f. Plasmid: pet-30. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: blr de-3.
Chains: A, B, C, D (235 residues) CATH domain: 3.90.1240.10
1epw
Crystal structure of clostridium neurotoxin type b
Source: Clostridium botulinum. Organism_taxid: 1491
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1f31
Crystal structure of clostridium botulinum neurotoxin b complexed with a trisaccharide
Source: Clostridium botulinum. Organism_taxid: 1491
Chain: A (1280 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1f82
Botulinum neurotoxin type b catalytic domain
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (424 residues) CATH domain: 3.90.1240.10
1f83
Botulinum neurotoxin type b catalytic domain with synaptobrevin-ii bound
Source: Clostridium botulinum. Bacteria. Expressed in: escherichia coli. Synthetic: yes. Other_details: this sequence occurs naturally in homo sapiens (humans). Sapiens (humans)
Chain: A (425 residues) CATH domain: 3.90.1240.10
1fqh
Botulinum neurotoxin type b catalytic domain with inhibitor
Source: Clostridium botulinum. Expressed in: escherichia coli.
Chain: A (424 residues) CATH domain: 3.90.1240.10
1g9a
Crystal structure of clostridium botulinum neurotoxin b complexed with an inhibitor (experiment 3)
Source: Clostridium botulinum. Organism_taxid: 1491
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1g9b
Crystal structure of clostridium botulinum neurotoxin b complexed with an inhibitor (experiment 1)
Source: Clostridium botulinum. Organism_taxid: 1491
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1g9c
Crystal structure of clostridium botulinum neurotoxin b complexed with an inhibitor (experiment 4)
Source: Clostridium botulinum. Organism_taxid: 1491
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1g9d
Crystal structure of clostridium botulinum neurotoxin b complexed with an inhibitor (experiment 2)
Source: Clostridium botulinum. Organism_taxid: 1491
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1i1e
Crystal structure of clostridium botulinum neurotoxin b complexed with doxorubicin
Source: Clostridium botulinum. Organism_taxid: 1491
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1s0b
Crystal structure of botulinum neurotoxin type b at ph 4.0
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type b
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1s0c
Crystal structure of botulinum neurotoxin type b at ph 5.0
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type b
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1s0d
Crystal structure of botulinum neurotoxin type b at ph 5.5
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type b
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1s0e
Crystal structure of botulinum neurotoxin type b at ph 6.0
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type b
Chain: A (1287 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1s0f
Crystal structure of botulinum neurotoxin type b at ph 7.0
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type b
Chain: A (1276 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1s0g
Crystal structure of botulinum neurotoxin type b apo form
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type b
Chain: A (1288 residues) CATH domains: 3.90.1240.10 1.20.1120.10 2.60.120.200 2.80.10.50
1t3a
Crystal structure of clostridium botulinum neurotoxin type e catalytic domain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc-11219. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (400 residues) CATH domain: 3.90.1240.10
1t3c
Clostridium botulinum type e catalytic domain e212q mutant
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc-11219. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (411 residues) CATH domain: 3.90.1240.10
1uee
The structure of substrate-bound botox light chain
Source: Clostridium botulinum. Bacteria. Homo sapiens. Human
Chain: A (496 residues)
1xtf
Neurotoxin bont/a e224q y366f mutant
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (427 residues) CATH domain: 3.90.1240.10
1xtg
Crystal structure of neurotoxin bont/a complexed with synaptosomal-associated protein 25
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: snap25, snap. Expressed in: escherichia coli bl21(de3).
Chain: A (424 residues) CATH domain: 3.90.1240.10
1z0h
N-terminal helix reorients in recombinant c-fragment of clostridium botulinum type b
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botb. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B (438 residues) CATH domains: 2.60.120.200 2.80.10.50
1zb7
Crystal structure of botulinum neurotoxin type g light chain
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (414 residues) CATH domain: 3.90.1240.10
1zkw
Crystal structure of arg347ala mutant of botulinum neurotoxin e catalytic domain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc-11219. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (411 residues) CATH domain: 3.90.1240.10
1zkx
Crystal structure of glu158ala/thr159ala/asn160ala- a triple mutant of clostridium botulinum neurotoxin e catalytic domain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc-11219. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (400 residues) CATH domain: 3.90.1240.10
1zl5
Crystal structure of glu335gln mutant of clostridium botulinum neurotoxin e catalytic domain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc-11219. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (400 residues) CATH domain: 3.90.1240.10
1zl6
Crystal structure of tyr350ala mutant of clostridium botulinum neurotoxin e catalytic domain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc-11219. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (400 residues) CATH domain: 3.90.1240.10
1zn3
Crystal structure of glu335ala mutant of clostridium botulinum neurotoxin type e
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc-11219. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (411 residues) CATH domain: 3.90.1240.10
2a8a
Crystal structure of clostridium botulinum neurotoxin seroty chain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc 10821. Gene: botf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (405 residues) CATH domain: 3.90.1240.10
2a97
Crystal structure of catalytic domain of clostridium botulinum neurotoxin serotype f
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: nctc 10821. Gene: botf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (392 residues) CATH domain: 3.90.1240.10
2etf
Crystal structure of full length botulinum neurotoxin (type b) light chain
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (432 residues) CATH domain: 3.90.1240.10
2fpq
Crystal structure of botulinum neurotoxin type d light chain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: d16phi. Gene: botd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (414 residues) CATH domain: 3.90.1240.10
2g7k
Structure of the light chain of botulinum neurotoxin, serotype a bound to small molecule inhibitors
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bota, atx, bna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (401 residues) CATH domain: 3.90.1240.10
2g7n
Structure of the light chain of botulinum neurotoxin serotype a bound to small molecule inhibitors
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bota, atx, bna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (415 residues) CATH domain: 3.90.1240.10
2g7p
Structure of the light chain of botulinum neurotoxin serotype a bound to small molecule inhibitors
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bota, atx, bna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (411 residues) CATH domain: 3.90.1240.10
2g7q
Structure of the light chain of botulinum neurotoxin serotype a bound to small molecule inhibitors
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bota, atx, bna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (411 residues) CATH domain: 3.90.1240.10
2nm1
Structure of bont/b in complex with its protein receptor
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botb. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Norway rat. Organism_taxid: 10116.
Chain: A (430 residues) CATH domains: 2.60.120.200 2.80.10.50
2np0
Crystal structure of the botulinum neurotoxin type b complex synaptotagamin-ii ectodomain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type b1_okra. Mus musculus. House mouse. Organism_taxid: 10090. Gene: syt2
Chain: A (1289 residues) CATH domains: 3.90.1240.10 Unassigned 2.60.120.200 2.80.10.50
2nyy
Crystal structure of botulinum neurotoxin type a complexed w monoclonal antibody cr1
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type a1 (hall strain). Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho dg44 cells.
Chain: A (1267 residues) CATH domains: 3.90.1240.10 Unassigned 2.60.120.200 2.80.10.50
2nz9
Crystal structure of botulinum neurotoxin type a complexed w monoclonal antibody ar2
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: type a1 (hall strain). Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho dg44 cells.
Chains: A, B (1267 residues) CATH domains: 3.90.1240.10 Unassigned 2.60.120.200 2.80.10.50
2vu9
Crystal structure of botulinum neurotoxin serotype a binding domain in complex with gt1b
Source: Clostridium botulinum. Organism_taxid: 36826. Strain: a. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (425 residues) CATH domains: 2.60.120.200 2.80.10.50
2vua
Crystal structure of the botulinum neurotoxin serotype a binding domain
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: a1. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (423 residues) CATH domains: 2.60.120.200 2.80.10.50
2vxr
Crystal structure of the botulinum neurotoxin serotype g binding domain
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (428 residues) CATH domains: 2.60.120.200 2.80.10.50
2w2d
Crystal structure of a catalytically active, non-toxic endopeptidase derivative of clostridium botulinum toxin a
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (437 residues) CATH domain: 3.90.1240.10
2xhl
Structure of a functional derivative of clostridium botulinum neurotoxin type b
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (430 residues) CATH domain: 3.90.1240.10
3bok
Structure of thE C. Botulinum neurotoxin serotype a apo- enzyme
Source: Clostridium botulinum. Gene: bota, atx, bna. Expressed in: escherichia coli.
Chain: A (416 residues) CATH domain: 3.90.1240.10
3bon
Structure of thE C. Botulinum neurotoxin serotype a with zn2+ cofactor bound
Source: Clostridium botulinum. Gene: bota, atx, bna. Expressed in: escherichia coli.
Chain: A (416 residues) CATH domain: 3.90.1240.10
3boo
Structure of thE C. Botulinum neurotoxin serotype a with an peptide bound
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bota, atx, bna. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: inhibitory peptide was chemically synthesize
Chain: A (419 residues) CATH domain: 3.90.1240.10
3bta
Crystal structure of botulinum neurotoxin serotype a
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall
Chain: A (1277 residues) CATH domains: 3.90.1240.10 Unassigned 2.60.120.200 2.80.10.50
3bwi
Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with an acetate ion bound at the active site
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Atcc: 3502. Gene: bota. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (423 residues) CATH domain: 3.90.1240.10
3c88
Crystal structure of the catalytic domain of botulinum neuro serotype a with inhibitory peptide rrgc
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Atcc: 3502. Gene: bota. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (422 residues) CATH domain: 3.90.1240.10
3c89
Crystal structure of the catalytic domain of botulinum neuro serotype a with inhibitory peptide rrgm
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Atcc: 3502. Gene: bota. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (422 residues) CATH domain: 3.90.1240.10
3c8a
Crystal structure of the catalytic domain of botulinum neuro serotype a with inhibitory peptide rrgl
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Atcc: 3502. Gene: bota. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (422 residues) CATH domain: 3.90.1240.10
3c8b
Crystal structure of the catalytic domain of botulinum neuro serotype a with inhibitory peptide rrgi
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Atcc: 3502. Gene: bota. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (423 residues) CATH domain: 3.90.1240.10
3dda
Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with a snap-25 peptide
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Atcc: 3502. Gene: bota. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the snap-25 peptide is naturally found in
Chain: A (423 residues) CATH domain: 3.90.1240.10
3ddb
Crystal structure of the catalytic domain of botulinum neurotoxin serotype a with a substrate analog peptide
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Atcc: 3502. Gene: bota. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the snap-25 peptide is naturally found in
Chain: A (423 residues) CATH domain: 3.90.1240.10
3deb
Crystal structure of apo form (zinc removed) of the botulinum neurotoxin typE C light chain
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bont/c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (432 residues) CATH domain: 3.90.1240.10
3ds9
A potent peptidomimetic inhibitor of botulinum neurotoxin serotype a has a very different conformation than snap-25 substrate
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Gene: bota, cbo0806, clc_0862. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (398 residues) CATH domain: 3.90.1240.10
3dse
A potent peptidomimetic inhibitor of botulinum neurotoxin se has a very different conformation than snap-25 substrate
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall. Gene: bota, cbo0806, clc_0862. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (394 residues) CATH domain: 3.90.1240.10
3ffz
Domain organization in clostridium butulinum neurotoxin type e is unique: its implication in faster translocation
Source: Clostridium botulinum. Organism_taxid: 1491
Chains: A, B (1246 residues) CATH domains: 3.90.1240.10 Unassigned 2.60.120.200 2.80.10.50
3fie
Crystal structure of clostridium botulinum neurotoxin serotype f catalytic domain with an inhibitor (inh1)
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bont/f. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: sequence occurs in homo sapiens
Chains: A, B (407 residues) CATH domain: 3.90.1240.10
3fii
Crystal structure of clostridium botulinum neurotoxin serotype f catalytic domain with an inhibitor (inh2)
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bont/f. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: sequence occurs in homo sapiens
Chain: A (403 residues) CATH domain: 3.90.1240.10
3fuo
The crystal structure of receptor binding domain of botulinum neurotoxin serotype a
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: atx, bna, bota, botulinum neurotoxin a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (416 residues) CATH domains: 2.60.120.200 2.80.10.50
3g94
Further refinement of botulinum neurotoxin type b catalytic domain with synaptobrevin-ii bound
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botb. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: homo sapien. Other_details: homo sapien
Chain: A (425 residues) CATH domain: 3.90.1240.10
3k3q
Crystal structure of a llama antibody complexed with thE C. Botulinum neurotoxin serotype a catalytic domain
Source: Lama glama. Organism_taxid: 9844. Gene: llama vhh immunoglobulin. Expressed in: escherichia coli. Expression_system_taxid: 562. Clostridium botulinum a str. Hall. Organism_taxid: 441771. Gene: bota, cbo0806, clc_0862, neurotoxin catalytic domain.
Chains: B, C (238 residues) CATH domain: 3.90.1240.10
3mpp
Botulinum neurotoxin type g receptor binding domain
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botg. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: G (403 residues) CATH domains: 2.60.120.200 2.80.10.50
3n7j
Crystal structure of botulinum neurotoxin serotype d binding
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botd, clostridium phage d-16 phi. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (405 residues) CATH domains: 2.60.120.200 2.80.10.50
3n7k
Crystal structure of botulinum neurotoxin serotype c1 bindin
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: clostridium phagE C-st gene. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (422 residues) CATH domains: 2.60.120.200 2.80.10.50
3obr
Crystal structure of botulinum neurotoxin serotype d binding
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (418 residues) CATH domains: 2.60.120.200 2.80.10.50
3obt
Crystal structure of botulinum neurotoxin serotype d ligand domain in complex with n-acetylneuraminic acid
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botd. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (412 residues) CATH domains: 2.60.120.200 2.80.10.50
3ogg
Crystal structure of the receptor binding domain of botulinu neurotoxin d
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botd, botulinum neurotoxin d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (404 residues) CATH domains: 2.60.120.200 2.80.10.50
3qix
Crystal structure of bont/a lc with zinc bound
Source: Clostridium botulinum. Organism_taxid: 441771. Strain: hall - serotype a. Gene: bota, cbo0806, clc_0862, neurotoxin light chain. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (396 residues) CATH domain: 3.90.1240.10
3qiy
Crystal structure of bont/a lc complexed with hydroxamate-ba inhibitor pt-1
Source: Clostridium botulinum. Organism_taxid: 441771. Strain: hall - serotype a. Gene: bota, cbo0806, clc_0862, neurotoxin light chain. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (391 residues) CATH domain: 3.90.1240.10
3qiz
Crystal structure of bont/a lc complexed with hydroxamate-ba inhibitor pt-2
Source: Clostridium botulinum. Organism_taxid: 441771. Strain: hall - serotype a. Gene: bota, cbo0806, clc_0862, neurotoxin light chain. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (399 residues) CATH domain: 3.90.1240.10
3qj0
Crystal structure of bont/a lc complexed with hydroxamate-ba inhibitor pt-3
Source: Clostridium botulinum. Organism_taxid: 441771. Strain: hall - serotype a. Gene: bota, cbo0806, clc_0862, neurotoxin light chain. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (395 residues) CATH domain: Unassigned
3qw5
Crystal structure of the protease domain of botulinum neurot serotype a with a peptide inhibitor rrgf
Source: Clostridium botulinum. Organism_taxid: 441771. Strain: hall / atcc 3502 / nctc 13319 / type a. Gene: bota, cbo0806, clc_0862. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (423 residues) CATH domain: 3.90.1240.10
3qw6
Crystal structure of the protease domain of botulinum neurot serotype a with a peptide inhibitor rygc
Source: Clostridium botulinum. Organism_taxid: 441771. Strain: hall / atcc 3502 / nctc 13319 / type a. Gene: bota, cbo0806, clc_0862. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (422 residues) CATH domain: 3.90.1240.10
3qw7
Crystal structure of the protease domain of botulinum neurot serotype a with a peptide inhibitor rrfc
Source: Clostridium botulinum. Organism_taxid: 441771. Strain: hall / atcc 3502 / nctc 13319 / type a. Gene: bota, cbo0806, clc_0862. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (422 residues) CATH domain: 3.90.1240.10
3qw8
Crystal structure of the protease domain of botulinum neurot serotype a with a peptide inhibitor crgc
Source: Clostridium botulinum. Organism_taxid: 441771. Strain: hall / atcc 3502 / nctc 13319 / type a. Gene: bota, cbo0806, clc_0862. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (422 residues) CATH domain: 3.90.1240.10
3r4s
Cell entry of botulinum neurotoxin typE C is dependent upon interaction with two ganglioside molecules
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (424 residues) CATH domains: 2.60.120.200 2.80.10.50
3r4u
Cell entry of botulinum neurotoxin typE C is dependent upon interaction with two ganglioside molecules
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (422 residues) CATH domains: 2.60.120.200 2.80.10.50
3rmx
Crystal structure of hcr/d f1240a mutant
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: d-1873. Gene: botd, botulinum neurotoxin d. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (404 residues) CATH domains: 2.60.120.200 2.80.10.50
3rmy
Crystal structure of hcr/d w1238a mutant
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: d-1873. Gene: botd, botulinum neurotoxin d. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (401 residues) CATH domains: 2.60.120.200 2.80.10.50
3v0a
2.7 angstrom crystal structure of bont/ai in complex with nt
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bont/a, bont/a, bonta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ant, ntnh. Lama glama. Organism_taxid: 9844. Expression_system_taxid: 562
Chain: A (1280 residues) CATH domains: 3.90.1240.10 Unassigned 2.60.120.200 2.80.10.50
3v0b
3.9 angstrom crystal structure of bont/ai in complex with nt
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bont/a, bont/a, bonta. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ant, ntnh. Expression_system_taxid: 562
Chain: A (1280 residues) CATH domains: 3.90.1240.10 Unassigned 2.60.120.200 2.80.10.50
3v0c
4.3 angstrom crystal structure of an inactive bont/a (e224q/r363a/y366f)
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bont/a, bont/a, bonta. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (1277 residues)
3zuq
Crystal structure of an engineered botulinum neurotoxin type b-derivative, lc-b-gs-hn-b
Source: Clostridium botulinum. Organism_taxid: 1491. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (850 residues) CATH domain: 3.90.1240.10
3zur
Crystal structure of an engineered botulinum neurotoxin type a-snare23 derivative, lc0-a-snap25-hn-a
Source: Clostridium botulinum, homo sapiens. Organism_taxid: 1491, 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (848 residues) CATH domain: 3.90.1240.10
3zus
Crystal structure of an engineered botulinum neurotoxin type a-snare23 derivative, lc-a-snap23-hn-a
Source: Clostridium botulinum, homo sapiens. Organism_taxid: 1491, 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: engineered human snap23 peptide inserted wit and hn of botulinum neurotoxin
Chains: A, B, C, D (851 residues) CATH domain: 3.90.1240.10
4ej5
Crystal structure of the catalytic domain of botulinum neuro bont/a wild-type
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall atcc 3502. Gene: bota, atx, bna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (433 residues) CATH domain: 3.90.1240.10
4el4
Crystal structure of the catalytic domain of botulinum neuro bont/a c134s/c165s double mutant
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall atcc 3502. Gene: atx, bna, bont/a, bota. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (425 residues) CATH domain: 3.90.1240.10
4elc
Crystal structure of the catalytic domain of botulinum neuro bont/a c134 mutant with mtsea modified cys-165
Source: Clostridium botulinum. Organism_taxid: 1491. Strain: hall atcc 3502. Gene: atx, bna, bont/a, bota. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (433 residues) CATH domain: 3.90.1240.10
4hev
Clostridium botulinum serotype a light chain inhibited by ad hydroxamate
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bota, atx, bna. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (397 residues) CATH domain: 3.90.1240.10
4iqp
Crystal structure of hcra-w1266a
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: atx, bna, bota, botulinum neurotoxin type a receptor domain. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (419 residues) CATH domains: 2.60.120.200 2.80.10.50
4jra
Crystal structure of the botulinum neurotoxin a receptor-bin domain in complex with the luminal domain of sv2c
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: bota, atx, bna. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: sv2c, kiaa1054.
Chains: A, B (416 residues) CATH domains: 2.60.120.200 2.80.10.50
4kbb
Structure of botulinum neurotoxin b binding domain in comple both synaptotagmin ii and gd1a
Source: Clostridium botulinum. Organism_taxid: 1491. Gene: botb. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090. Gene: syt2.
Chains: A, B (417 residues) CATH domains: 2.60.120.200 2.80.10.50
4ks6
Crystal structure of the catalytic domain of botulinum neuro bont/a c134s mutant with covalent inhibitor that modifies c causing disorder in 166-174 stretch
Source: Clostridium botulinum a. Organism_taxid: 441771. Strain: strain hall / atcc 3502 / nctc 13319 / type a. Gene: bota, cbo0806, clc_0862. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (428 residues) CATH domain: 3.90.1240.10
4kuf
Crystal structure of the catalytic domain of botulinum neuro bont/a c134 mutant with mtsea modified cys-165 causing stre disorder
Source: Clostridium botulinum a. Organism_taxid: 441771. Strain: strain hall / atcc 3502 / nctc 13319 / type a. Gene: bota, cbo0806, clc_0862. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (426 residues) CATH domain: 3.90.1240.10