_EC 3.4.24.15 Thimet oligopeptidase. 2 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.24.- Metalloendopeptidases. [610 PDB entries]
EC 3.4.24.15 Thimet oligopeptidase. [2 PDB entries]    
1s4b

Reaction: Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.
Other name(s): Endo-oligopeptidase A. Endopeptidase 24.15. Pz-peptidase. Soluble metalloendopeptidase.
Cofactor(s): Zn(2+).
Comments: Thiol compounds activate at low concentrations. Belongs to peptidase family M3. Formerly Ec 3.4.22.19 and Ec 3.4.99.31.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.3.4.24.15

  PDB code Protein
1s4b
Crystal structure of human thimet oligopeptidase.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: thop1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: P (654 residues) CATH domains: 1.20.1050.40 1.10.1370.10 3.40.390.10
2o36
Crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: thop1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (654 residues) CATH domains: 1.20.1050.40 1.10.1370.10 3.40.390.10