_EC 3.4.23.46 Memapsin 2. 295 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,846 PDB entries]
EC 3.4.23.- Aspartic endopeptidases. [1,467 PDB entries]
EC 3.4.23.46 Memapsin 2. [295 PDB entries]    
1fkn

Reaction: Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
Other name(s): BACE1. Beta-secretase. Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1. Beta-site APP-cleaving enzyme 1. Membrane-associated aspartic protease 2.
Comments: Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. Belongs to peptidase family A1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 295 PDB entries in enzyme class E.C.3.4.23.46

  PDB code Protein
1fkn
Structure of beta-secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (391 residues) CATH domains: 2.40.70.10 2.40.70.10
1m4h
Crystal structure of beta-secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (391 residues) CATH domains: 2.40.70.10 2.40.70.10
1sgz
Crystal structure of unbound beta-secretase catalytic domain.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (389 residues) CATH domains: 2.40.70.10 2.40.70.10
1tqf
Crystal structure of human beta secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
1w50
Apo structure of bace (beta secretase)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (378 residues) CATH domains: 2.40.70.10 2.40.70.10
1w51
Bace (beta secretase) in complex with a nanomolar non- peptidic inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
1xn2
New substrate binding pockets for beta-secretase.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes
Chains: A, B, C, D (389 residues) CATH domains: 2.40.70.10 2.40.70.10
1xn3
Crystal structure of beta-secretase bound to a long inhibito additional upstream residues.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes
Chains: A, B, C, D (389 residues) CATH domains: 2.40.70.10 2.40.70.10
1xs7
Crystal structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: D (389 residues) CATH domains: 2.40.70.10 2.40.70.10
1ym2
Crystal structure of human beta secretase complexed with nvp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B, C (376 residues) CATH domains: 2.40.70.10 2.40.70.10
1ym4
Crystal structure of human beta secretase complexed with nvp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B, C (379 residues) CATH domains: 2.40.70.10 2.40.70.10
2b8l
Crystal structure of human beta secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
2b8v
Crystal structure of human beta-secretase complexed with l- l000430,469
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
2f3e
Crystal structure of the bace complex with axq093, a macrocyclic inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2f3f
Crystal structure of the bace complex with bdf488, a macrocyclic inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2fdp
Crystal structure of beta-secretase complexed with an amino- ethylene inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (373 residues) CATH domains: 2.40.70.10 2.40.70.10
2g94
Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (389 residues) CATH domains: 2.40.70.10 2.40.70.10
2hiz
Crystal structure of human beta-secretase (bace) in the presence of an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (371 residues) CATH domains: 2.40.70.10 2.40.70.10
2hm1
Crystal structure of human beta-secretase (bace) in the presence of an inhibitor (2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2iqg
Crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitor of human beta-secretase (bace)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2irz
Crystal structure of human beta-secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
2is0
Crystal structure of human beta-secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
2ntr
Crystal structure of human bace-1 bound to inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
2oah
Crystal structure of human beta secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (378 residues) CATH domains: 2.40.70.10 2.40.70.10
2of0
X-ray crystal structure of beta secretase complexed with compound 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohk
X-ray crystal structure of beta secretase complexed with 1- amino-isoquinoline
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohl
X-ray crystal structure of beta secretase complexed with 2- aminoquinoline
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohm
X-ray crystal structure of beta secretase complexed with n~3~-benzylpyridine-2,3-diamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohn
X-ray crystal structure of beta secretase complexed with 4- (4-fluorobenzyl)piperidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohp
X-ray crystal structure of beta secretase complexed with compound 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohq
X-ray crystal structure of beta secretase complexed with com
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohr
X-ray crystal structure of beta secretase complexed with com
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohs
X-ray crystal structure of beta secretase complexed with compound 6b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
2oht
X-ray crystal structure of beta secretase complexed with compound 7
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2ohu
X-ray crystal structure of beta secretase complexed with compound 8b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2p4j
Crystal structure of beta-secretase bond to an inhibitor with isophthalamide derivatives at p2-p3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (389 residues) CATH domains: 2.40.70.10 2.40.70.10
2p83
Potent and selective isophthalamide s2 hydroxyethylamine inhibitor of bace1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (371 residues) CATH domains: 2.40.70.10 2.40.70.10
2p8h
Crystal structure of human beta secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
2ph6
Crystal structure of human beta secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
2ph8
Crystal structure of human beta secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (365 residues) CATH domains: 2.40.70.10 2.40.70.10
2q11
Structure of bace complexed to compound 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B, C (388 residues) CATH domains: 2.40.70.10 2.40.70.10
2q15
Structure of bace complexed to compound 3a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (385 residues) CATH domains: 2.40.70.10 2.40.70.10
2qk5
Structure of bace1 bound to sch626485
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (395 residues) CATH domains: 2.40.70.10 2.40.70.10
2qmd
Structure of bace bound to sch722924
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
2qmf
Structure of bace bound to sch735310
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
2qmg
Structure of bace bound to sch745966
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
2qp8
Structure of bace bound to sch734723
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
2qu2
Bace1 with compound 1
Source: Homo sapiens. Human. Gene: bace1, bace. Expressed in: escherichia coli
Chain: A (364 residues) CATH domains: 2.40.70.10 2.40.70.10
2qu3
Bace1 with compound 2
Source: Homo sapiens. Human. Gene: bace1, bace. Expressed in: escherichia coli
Chain: A (368 residues) CATH domains: 2.40.70.10 2.40.70.10
2qzk
Crystal structure of human beta secretase complexed with i21
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (376 residues) CATH domains: 2.40.70.10 2.40.70.10
2qzl
Crystal structure of human beta secretase complexed with ixs
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2va5
X-ray crystal structure of beta secretase complexed with compound 8c
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: brain. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (378 residues) CATH domains: 2.40.70.10 2.40.70.10
2va6
X-ray crystal structure of beta secretase complexed with compound 24
Source: Homo sapiens. Organism_taxid: 9606. Organ: brain. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2va7
X-ray crystal structure of beta secretase complexed with compound 27
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: brain. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2vie
Human bace-1 in complex with n-((1s,2r)-1-benzyl-2-hydroxy- 3-((1,1,5-trimethylhexyl)amino)propyl)-3-(ethylamino)-5-(2- oxopyrrolidin-1-yl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
2vij
Human bace-1 in complex with 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( phenylmethyl)-3-(1,2,3,4-tetrahydro-1-naphthalenylamino) propyl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
2viy
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-( cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( phenylmethyl)propyl)-3-(pentylsulfonyl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
2viz
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-( cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( phenylmethyl)propyl)-3-(2-oxo-1-pyrrolidinyl)-5-(propyloxy) benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
2vj6
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-( cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- pyrrolidinyl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
2vj7
Human bace-1 in complex with 3-(ethylamino)-n-((1s,2r)-2- hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl) methyl)amino)propyl)-5-(2-oxo-1-pyrrolidinyl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
2vj9
Human bace-1 in complex with n-((1s,2r)-3-(cyclohexylamino)- 2-hydroxy-1-(phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo- 1-pyrrolidinyl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2vkm
Crystal structure of grl-8234 bound to bace (beta-secretase)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (389 residues) CATH domains: 2.40.70.10 2.40.70.10
2vnm
Human bace-1 in complex with 3-(1,1-dioxidotetrahydro-2h-1, 2-thiazin-2-yl)-5-(ethylamino)-n-((1s,2r)-2-hydroxy-1-( phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) propyl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2vnn
Human bace-1 in complex with 7-ethyl-n-((1s,2r)-2-hydroxy-1- (phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- hi)indole-9-carboxamide 2,2-dioxide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2wez
Human bace-1 in complex with 1-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) propyl)-4-(2-oxo-1-pyrrolidinyl)-1h-indole-6-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
2wf0
Human bace-1 in complex with 4-ethyl-n-((1s,2r)-2-hydroxy-1- (phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino) propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
2wf1
Human bace-1 in complex with 7-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl(methyl)amino)-1-(phenylmethyl) propyl)-1-methyl-3,4-dihydro-1h-(1,2,5)thiadiazepino(3,4,5- hi)indole-9-carboxamide 2,2-dioxide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2wf2
Human bace-1 in complex with 8-ethyl-n-((1s,2r)-2-hydroxy-3- (((3-(methyloxy)phenyl)methyl)amino)-1-(phenylmethyl) propyl)-1-methyl-3,4,7,8-tetrahydro-1h,6h-(1,2,5) thiadiazepino(5,4,3-de)quinoxaline-10-carboxamide 2,2- dioxide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2wf3
Human bace-1 in complex with 6-(ethylamino)-n-((1s,2r)-2- hydroxy-3-(((3-(methyloxy)phenyl)methyl)amino)-1-( phenylmethyl)propyl)-1-methyl-1,3,4,5-tetrahydro-2,1- benzothiazepine-8-carboxamide 2,2-dioxide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
2wf4
Human bace-1 in complex with 6-ethyl-1-methyl-n-((1s)-2-oxo- 1-(phenylmethyl)-3-(tetrahydro-2h-pyran-4-ylamino)propyl)- 1,3,4,6-tetrahydro(1,2)thiazepino(5,4,3-cd)indole-8- carboxamide 2,2-dioxide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
2wjo
Human bace (beta secretase) in complex with cyclohexanecarboxylic acid (2-(2-am ino-6-phenoxy-4h- quinazolin-3-yl)-2-cyclohexyl-ethyl)-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: drosophila. Expression_system_taxid: 7215
Chain: A (381 residues) CATH domains: 2.40.70.10 2.40.70.10
2xfi
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-( cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( phenylmethyl)propyl)-3-((methylsulfonyl)(phenyl)amino) benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
2xfj
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-( cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( phenylmethyl)propyl)-3-(ethylamino)-5-(2-oxo-1- pyrrolidinyl)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
2xfk
Human bace-1 in complex with n-((1s,2r)-3-(((1s)-2-( cyclohexylamino)-1-methyl-2-oxoethyl)amino)-2-hydroxy-1-( phenylmethyl)propyl)-3-(ethylamino)-5-((methylsulfonyl)( phenyl)amino)benzamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary
Chain: A (372 residues) CATH domains: 2.40.70.10 2.40.70.10
2zdz
X-ray structure of bace-1 in complex with compound 3.B.10
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
2ze1
X-ray structure of bace-1 in complex with compound 6g
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (360 residues) CATH domains: 2.40.70.10 2.40.70.10
2zhr
Crystal structure of bace1 in complex with om99-2 at ph 5.0
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
2zhs
Crystal structure of bace1 at ph 4.0
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
2zht
Crystal structure of bace1 at ph 4.5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
2zhu
Crystal structure of bace1 at ph 5.0
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
2zhv
Crystal structure of bace1 at ph 7.0
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
2zjh
Crystal structure of the human bace1 catalytic domain in com n-(1-benzyl-piperidin-4-yl)-4-mercapto-butyramide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (356 residues) CATH domains: 2.40.70.10 2.40.70.10
2zji
Crystal structure of the human bace1 catalytic domain in com n-[1-(2,6-dimethoxy-benzyl)-piperidin-4-yl]-4-mercapto-buty
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
2zjj
Crystal structure of the human bace1 catalytic domain in com 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid (2-mercapt amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
2zjk
Crystal structure of the human bace1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (371 residues) CATH domains: 2.40.70.10 2.40.70.10
2zjl
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-bromo-2,3-dimethoxy-benzyl)-piperidin- 4-yl]-4-mercapto-butyramide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (344 residues) CATH domains: 2.40.70.10 2.40.70.10
2zjm
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- piperidin-4-yl]-2-(4-sulfamoyl-phenoxy)-acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
2zjn
Crystal structure of the human bace1 catalytic domain in complex with n-[1-(5-chloro-2-isopropoxy-3-methoxy-benzyl)- piperidin-4-yl]-2-(2-methyl-4-sulfamoyl-phenoxy)-acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (367 residues) CATH domains: 2.40.70.10 2.40.70.10
3bra
Bace-1 complexed with compound 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
3buf
Bace-1 complexed with compound 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (359 residues) CATH domains: 2.40.70.10 2.40.70.10
3bug
Bace-1 complexed with compound 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (357 residues) CATH domains: 2.40.70.10 2.40.70.10
3buh
Bace-1 complexed with compound 4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
3cib
Structure of bace bound to sch727596
Source: Homo sapiens. Human. Gene: bace1, bace. Expressed in: escherichia coli.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3cic
Structure of bace bound to sch709583
Source: Homo sapiens. Human. Gene: bace1, bace. Expressed in: escherichia coli.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3cid
Structure of bace bound to sch726222
Source: Homo sapiens. Human. Gene: bace1, bace. Expressed in: escherichia coli.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3ckp
Crystal structure of bace-1 in complex with inhibitor
Source: Homo sapiens. Human. Expressed in: escherichia coli
Chains: A, B, C (379 residues) CATH domains: 2.40.70.10 2.40.70.10
3ckr
Crystal structure of bace-1 in complex with inhibitor
Source: Homo sapiens. Human. Expressed in: escherichia coli
Chains: A, B, C (379 residues) CATH domains: 2.40.70.10 2.40.70.10
3dm6
Beta-secretase 1 complexed with statine-based inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (369 residues) CATH domains: 2.40.70.10 2.40.70.10
3duy
Crystal structure of human beta-secretase in complex with nvp-afj144
Source: Homo sapiens. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (370 residues) CATH domains: 2.40.70.10 2.40.70.10
3dv1
Crystal structure of human beta-secretase in complex with nvp-arv999
Source: Homo sapiens. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
3dv5
Crystal structure of human beta-secretase in complex with nvp-bav544
Source: Homo sapiens. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
3e3w
Crystal structure of human beta secretase complexed with spiropiperdine imidohydantoin inhibitor.
Source: Homo sapiens. Organism_taxid: 9606. Gene: bace1, bace. Expressed in: escherichia coli.
Chain: A (368 residues) CATH domains: 2.40.70.10 2.40.70.10
3exo
Crystal structure of bace1 bound to inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
3fkt
Crystal structure of human beta secretase complexed with spiropiperdine iminohydantoin inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (368 residues) CATH domains: 2.40.70.10 2.40.70.10
3h0b
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, beta-secretase, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (372 residues) CATH domains: 2.40.70.10 2.40.70.10
3hvg
Structure of bace (beta secretase) in complex with ev0
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (379 residues) CATH domains: 2.40.70.10 2.40.70.10
3hw1
Structure of bace (beta secretase) in complex with ligand ev
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (370 residues) CATH domains: 2.40.70.10 2.40.70.10
3i25
Potent beta-secretase 1 hydroxyethylene inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (373 residues) CATH domains: 2.40.70.10 2.40.70.10
3igb
Bace-1 with compound 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 2.40.70.10 2.40.70.10
3in3
Bace1 with compound 30
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
3in4
Bace1 with compound 38
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
3ind
Bace1 with the aminohydantoin compound 29
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
3ine
Bace1 with the aminohydantoin compound s-34
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (367 residues) CATH domains: 2.40.70.10 2.40.70.10
3inf
Bace1 with the aminohydantoin compound 37
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (367 residues) CATH domains: 2.40.70.10 2.40.70.10
3inh
Bace1 with the aminohydantoin compound r-58
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (366 residues) CATH domains: 2.40.70.10 2.40.70.10
3ivh
Design and synthesis of potent bace-1 inhibitors with cellul activity: structure-activity relationship of p1 substituent
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
3ivi
Design and synthesis of potent bace-1 inhibitors with cellul activity: structure-activity relationship of p1 substituent
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (380 residues) CATH domains: 2.40.70.10 2.40.70.10
3ixj
Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (373 residues) CATH domains: 2.40.70.10 2.40.70.10
3ixk
Potent beta-secretase 1 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (373 residues) CATH domains: 2.40.70.10 2.40.70.10
3k5c
Human bace-1 complex with nb-216
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
3k5d
Crystal structure of bace-1 in complex with ahm178
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (375 residues) CATH domains: 2.40.70.10 2.40.70.10
3k5f
Human bace-1 complex with ayh011
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (373 residues) CATH domains: 2.40.70.10 2.40.70.10
3k5g
Human bace-1 complex with bjc060
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
3kmx
Structure of bace bound to sch346572
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (395 residues) CATH domains: 2.40.70.10 2.40.70.10
3kmy
Structure of bace bound to sch12472
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (395 residues) CATH domains: 2.40.70.10 2.40.70.10
3kn0
Structure of bace bound to sch708236
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (387 residues) CATH domains: 2.40.70.10 2.40.70.10
3kyr
Bace-1 in complex with a norstatine type inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (365 residues) CATH domains: 2.40.70.10 2.40.70.10
3l38
Bace1 in complex with the aminopyridine compound 44
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (364 residues) CATH domains: 2.40.70.10 2.40.70.10
3l3a
Bace-1 with the aminopyridine compound 32
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (365 residues) CATH domains: 2.40.70.10 2.40.70.10
3l58
Structure of bace bound to sch589432
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (395 residues) CATH domains: 2.40.70.10 2.40.70.10
3l59
Structure of bace bound to sch710413
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3l5b
Structure of bace bound to sch713601
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (387 residues) CATH domains: 2.40.70.10 2.40.70.10
3l5c
Structure of bace bound to sch723871
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (387 residues) CATH domains: 2.40.70.10 2.40.70.10
3l5d
Structure of bace bound to sch723873
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (386 residues) CATH domains: 2.40.70.10 2.40.70.10
3l5e
Structure of bace bound to sch736062
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3l5f
Structure of bace bound to sch736201
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3lhg
Bace1 in complex with the aminohydantoin compound 4g
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 2.40.70.10 2.40.70.10
3lnk
Structure of bace bound to sch743813
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (387 residues) CATH domains: 2.40.70.10 2.40.70.10
3lpi
Structure of bace bound to sch745132
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3lpj
Structure of bace bound to sch743641
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3lpk
Structure of bace bound to sch747123
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
3msj
Structure of bace (beta secretase) in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (373 residues) CATH domains: 2.40.70.10 2.40.70.10
3msk
Fragment based discovery and optimisation of bace-1 inhibito
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (378 residues) CATH domains: 2.40.70.10 2.40.70.10
3msl
Fragment based discovery and optimisation of bace-1 inhibito
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
3msm
Fragment based discovery and optimisation of bace-1 inhibito
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (378 residues) CATH domains: 2.40.70.10 2.40.70.10
3n4l
Bace-1 in complex with eln380842
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (375 residues) CATH domains: 2.40.70.10 2.40.70.10
3nsh
Bace-1 in complex with eln475957
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (372 residues) CATH domains: 2.40.70.10 2.40.70.10
3ohf
Crystal structure of beta-site app-cleaving enzyme 1 (bace-w with bms-655295 aka n~3~-((1s,2r)-1- benzyl-2-hydroxy-3-((3 methoxybenzyl)amino)propyl)-n~1~, n~1~-dibutyl-1h-indole-1, dicarboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (387 residues) CATH domains: 2.40.70.10 2.40.70.10
3ohh
Crystal structure of beta-site app-cleaving enzyme 1 (bace-w with bms-681889 aka n~1~-butyl-5-cyano- n~3~-((1s,2r)-1-(3, difluorobenzyl)-2-hydroxy-3-((3- methoxybenzyl)amino)propyl methyl-1h-indole-1,3- dicarboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (387 residues) CATH domains: 2.40.70.10 2.40.70.10
3ooz
Bace1 in complex with the aminohydantoin compound 102
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (368 residues) CATH domains: 2.40.70.10 2.40.70.10
3pi5
Crystal structure of human beta secretase in complex with bf
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
3qbh
Structure based design, synthesis and sar of cyclic hydroxye (hea) bace-1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (375 residues) CATH domains: 2.40.70.10 2.40.70.10
3qi1
Design and synthesis of hydroxyethylamine (hea) bace-1 inhib prime side chromane-containing inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (382 residues) CATH domains: 2.40.70.10 2.40.70.10
3r1g
Structure basis of allosteric inhibition of bace1 by an exos binding antibody
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 9606
Chain: B (381 residues) CATH domains: 2.40.70.10 2.40.70.10
3r2f
Crystal structure of beta-site app-cleaving enzyme 1 (bace-w with bms-693391 aka (2s)-2-((3r)-3-acetamido-3-isobutyl-2-o pyrrolidinyl)-n-((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2 4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, D, E (386 residues) CATH domains: 2.40.70.10 2.40.70.10
3rsv
Structure of bace-1 (beta-secretase) in complex with (r)-3-( o-tolylquinolin-3-yl)-n-((r)-2,2-dimethyltetrahydro-2h-pyra methylpropanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (364 residues) CATH domains: 2.40.70.10 2.40.70.10
3rsx
Structure of bace-1 (beta-secretase) in complex with 6-(thio yl)quinolin-2-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
3rth
Structure of bace-1 (beta-secretase) in complex with 6-(2-(3 dimethylbut-1-ynyl)phenyl)quinolin-2-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
3rtm
Structure of bace-1 (beta-secretase) in complex with 3-(2- aminoquinolin-3-yl)-n-cyclohexyl-n-methylpropanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 2.40.70.10 2.40.70.10
3rtn
Structure of bace-1 (beta-secretase) in complex with 3-(2-am tolylquinolin-3-yl)-n-cyclohexylpropanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (367 residues) CATH domains: 2.40.70.10 2.40.70.10
3ru1
Structure of bace-1 (beta-secretase) in complex with 3-(2- aminoquinolin-3-yl)-n-(cyclohexylmethyl)propanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (363 residues) CATH domains: 2.40.70.10 2.40.70.10
3rvi
Structure of bace-1 (beta-secretase) in complex with 2-((2-a tolylquinolin-3-yl)methyl)-n-(cyclohexylmethyl)pentanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 2.40.70.10 2.40.70.10
3s2o
Fragment based discovery and optimisation of bace-1 inhibito
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (378 residues) CATH domains: 2.40.70.10 2.40.70.10
3s7l
Pyrazolyl and thienyl aminohydantoins as potent bace1 inhibi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 2.40.70.10 2.40.70.10
3s7m
Pyrazolyl and thienyl aminohydantoins as potent bace1 inhibi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
3skf
Crystal structure of beta-site app-cleaving enzyme 1 (bace-w with (2s)-2-((3s)-3-(acetylamino)-3-(butan-2-yl)-2-oxopyrro yl)-n-((2s,3r)-3-hydroxy-4-((3-methoxybenzyl)amino)-1-pheny yl)-4-phenylbutanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (387 residues) CATH domains: 2.40.70.10 2.40.70.10
3skg
Crystal structure of beta-site app-cleaving enzyme 1 (bace-w with (2s)-2-((3r)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidin ((1s,2r)-1-(3,5-difluorobenzyl)-2-hydroxy-2-(1,2,3,4-tetrah isoquinolinyl)ethyl)-4-phenylbutanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, D, E (386 residues) CATH domains: 2.40.70.10 2.40.70.10
3tpj
Apo structure of bace1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
3tpl
Apo structure of bace1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (371 residues) CATH domains: 2.40.70.10 2.40.70.10
3tpp
Crystal structure of bace1 complexed with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
3tpr
Crystal structure of bace1 complexed with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
3u6a
Rational design and synthesis of aminopiperazinones as beta (bace) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (374 residues) CATH domains: 2.40.70.10 2.40.70.10
3udh
Crystal structure of bace with compound 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3udj
Crystal structure of bace with compound 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3udk
Crystal structure of bace with compound 6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3udm
Crystal structure of bace with compound 8
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3udn
Crystal structure of bace with compound 9
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3udp
Crystal structure of bace with compound 12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3udq
Crystal structure of bace with compound 13
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3udr
Crystal structure of bace with compound 14
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3udy
Crystal structure of bace with compound 11
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
3ufl
Discovery of pyrrolidine-based b-secretase inhibitors: lead advancement through conformational design for maintenance o binding efficiency
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
3uqp
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide inhibitor
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
3uqr
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide inhibitor
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
3uqu
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
3uqw
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
3uqx
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
3veu
Crystal structure of human beta secretase in complex with nv
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (380 residues) CATH domains: 2.40.70.10 2.40.70.10
3vf3
Crystal structure of human beta secretase in complex with nv
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
3vg1
Crystal structure of human beta secretase in complex with nv derived from a soaking experiment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (376 residues) CATH domains: 2.40.70.10 2.40.70.10
3vv6
Crystal structure of beta secetase in complex with 2-amino-3 ((1s, 2r)-2-phenylcyclopropyl)pyrimidin-4(3h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (360 residues) CATH domains: 2.40.70.10 2.40.70.10
3vv7
Crystal structure of beta secetase in complex with 2-amino-6 2-(3'-methoxybiphenyl-3-yl)cyclopropyl)-3-methylpyrimidin-4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (361 residues) CATH domains: 2.40.70.10 2.40.70.10
3vv8
Crystal structure of beta secetase in complex with 2-amino-3 ((1s,2r)-2-(3'-methylbiphenyl-4-yl)cyclopropyl)pyrimidin-4(
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (358 residues) CATH domains: 2.40.70.10 2.40.70.10
3wb4
Crystal structure of beta secetase in complex with 2-amino-3 dimethyl-6-(2-phenylethyl)-3,4,5,6-tetrahydropyrimidin-4-on
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (360 residues) CATH domains: 2.40.70.10 2.40.70.10
3wb5
Crystal structure of beta secetase in complex with (6s)-2-am dimethyl-6-[(1r,2r)-2-phenylcyclopropyl]-3,4,5,6-tetrahydro 4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (361 residues) CATH domains: 2.40.70.10 2.40.70.10
3zmg
Crystal structure of bace-1 in complex with chemical ligand
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (385 residues) CATH domains: 2.40.70.10 2.40.70.10
3zov
Crystal structure of bace-1 in complex with chemical ligand
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
4acu
Aminoimidazoles as bace-1 inhibitors. X-ray crystal structur beta secretase complexed with compound 14
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (372 residues) CATH domains: 2.40.70.10 2.40.70.10
4acx
Aminoimidazoles as bace-1 inhibitors. X-ray crystal structur beta secretase complexed with compound 23
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
4azy
Design and synthesis of bace1 inhibitors with in vivo brain reduction of beta-amyloid peptides (compound 10)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4b00
Design and synthesis of bace1 inhibitors with in vivo brain reduction of beta-amyloid peptides (compound (r)-41)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4b05
Preclinical characterization of azd3839, a novel clinical candidate bace1 inhibitor for the treatment of alzheimer disease
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
4b0q
Lead generation of bace1 inhibitors by coupling non-amidine new warheads to a known binding scaffold
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 2.40.70.10 2.40.70.10
4b1c
New aminoimidazoles as bace-1 inhibitors: from rational design to ab-lowering in brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4b1d
New aminoimidazoles as bace-1 inhibitors: from rational desi ab-lowering in brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (376 residues) CATH domains: 2.40.70.10 2.40.70.10
4b1e
New aminoimidazoles as bace-1 inhibitors: from rational design to ab-lowering in brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4b70
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab-lowering in brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (372 residues) CATH domains: 2.40.70.10 2.40.70.10
4b72
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab-lowering in brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (376 residues) CATH domains: 2.40.70.10 2.40.70.10
4b77
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab-lowering in brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (376 residues) CATH domains: 2.40.70.10 2.40.70.10
4b78
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab-lowering in brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (372 residues) CATH domains: 2.40.70.10 2.40.70.10
4bek
Crystal structure of bace-1 in complex with chemical ligand
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
4bfd
Crystal structure of bace-1 in complex with chemical ligand
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (372 residues) CATH domains: 2.40.70.10 2.40.70.10
4d83
Crystal structure of human beta secretase in complex with nv derived from a co-crystallization experiment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
4d85
Crystal structure of human beta secretase in complex with nv
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
4d88
Crystal structure of human beta secretase in complex with nv
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4d89
Crystal structure of human beta secretase in complex with nv derived from a soaking experiment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4d8c
Crystal structure of human beta secretase in complex with nv derived from a co-crystallization experiment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
4dh6
Structure of bace-1 (beta-secretase) in complex with (2r)-n- 1-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-((s)-6'-neopentyl- dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-yla butan-2-yl)-2-methoxypropanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (367 residues) CATH domains: 2.40.70.10 2.40.70.10
4di2
Crystal structure of bace1 in complex with hydroxyethylamine 37
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4dju
Structure of bace bound to 2-imino-3-methyl-5,5-diphenylimid 4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4djv
Structure of bace bound to 2-imino-5-(3'-methoxy-[1,1'-biphe yl)-3-methyl-5-phenylimidazolidin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4djw
Structure of bace bound to 2-imino-3-methyl-5-phenyl-5-(3-(p yl)phenyl)imidazolidin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4djx
Structure of bace bound to 5-(3-(5-chloropyridin-3-yl)phenyl cyclopropyl-2-imino-3-methylimidazolidin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4djy
Structure of bace bound to (r)-5-cyclopropyl-2-imino-3-methy (prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4dpf
Bace-1 in complex with a hea-macrocyclic type inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4dpi
Bace-1 in complex with hea-macrocyclic inhibitor, mv078512
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
4dus
Structure of bace-1 (beta-secretase) in complex with n-((2s, fluorophenyl)-3-hydroxy-4-((6'-neopentyl-3',4'- dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)a butan-2-yl)acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (365 residues) CATH domains: 2.40.70.10 2.40.70.10
4dv9
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide inhibitor
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
4dvf
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide inhibitor
Chains: A, B (374 residues) CATH domains: 2.40.70.10 2.40.70.10
4ewo
Design and synthesis of potent hydroxyethylamine (hea) bace- inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
4exg
Design and synthesis of potent hydroxyethylamine (hea) bace- inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (377 residues) CATH domains: 2.40.70.10 2.40.70.10
4fco
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
4fgx
Crystal structure of bace1 with novel inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4fm7
Crystal structure of bace with compound 14g
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
4fm8
Crystal structure of bace with compound 12a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (394 residues) CATH domains: 2.40.70.10 2.40.70.10
4fri
Crystal structure of bace1 in complex with biarylspiro amino 6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (372 residues) CATH domains: 2.40.70.10 2.40.70.10
4frj
Crystal structure of bace1 in complex with aminooxazoline xa
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
4frk
Crystal structure of bace1 in complex with aminooxazoline xa
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 2.40.70.10 2.40.70.10
4frs
Structure of bace in complex with (s)-4-(3-chloro-5-(5-(prop yl)pyridin-3-yl)thiophen-2-yl)-1,4-dimethyl-6-oxotetrahydro 2(1h)-iminium
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (386 residues) CATH domains: 2.40.70.10 2.40.70.10
4fs4
Structure of bace bound to (s)-4-(3'-methoxy-[1,1'-biphenyl] 4-dimethyl-6-oxotetrahydropyrimidin-2(1h)-iminium
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4fse
Crystal structure of beta-site app-cleaving enzyme 1 (bace-w with n-(n-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4- methoxyphenyl)-5- methyl-4-isothiazolecarboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D, E (387 residues) CATH domains: 2.40.70.10 2.40.70.10
4fsl
Crystal structure of beta-site app-cleaving enzyme 1 (bace-d complex with n-(n-(4- acetamido-3-chloro-5-methylbenzyl) carbamimidoyl)-3-(4- methoxyphenyl)-5-methyl-4-isothiazolec
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, D, E (387 residues) CATH domains: 2.40.70.10 2.40.70.10
4gid
Structure of beta-secretase complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (387 residues) CATH domains: 2.40.70.10 2.40.70.10
4gmi
Bace-1 in complex with hea-type macrocyclic inhibitor, mv078
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (380 residues) CATH domains: 2.40.70.10 2.40.70.10
4h1e
Structure of bace-1 bound to (7ar)-6-benzoyl-7a-(4-(3-cyanop thiophen-2-yl)-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyr 2(3h)-iminium
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3). Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (386 residues) CATH domains: 2.40.70.10 2.40.70.10
4h3f
Structure of bace bound to 3-(5-((7ar)-2-imino-6-(6-methoxyp yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-y thiophen-3-yl)benzonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4h3g
Structure of bace bound to 2-((7ar)-7a-(4-(3-cyanophenyl)thi yl)-2-imino-3-methyl-4-oxohexahydro-1h-pyrrolo[3,4-d]pyrimi yl)nicotinonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4h3i
Structure of bace bound to 3-(5-((7ar)-2-imino-6-(3-methoxyp yl)-3-methyl-4-oxooctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-y thiophen-3-yl)benzonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (387 residues) CATH domains: 2.40.70.10 2.40.70.10
4h3j
Structure of bace bound to 2-fluoro-5-(5-(2-imino-3-methyl-4 phenyloctahydro-1h-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-2 benzonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4ha5
Structure of bace bound to (s)-3-(5-(2-imino-1,4-dimethyl-6- oxohexahydropyrimidin-4-yl)thiophen-3-yl)benzonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4hzt
Structure-based design of novel dihydroisoquinoline bace-1 i that do not engage the catalytic aspartates
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (393 residues) CATH domains: 2.40.70.10 2.40.70.10
4i0d
Design and synthesis of thiophene dihydroisoquinolins as nov inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149
Chain: A (387 residues) CATH domains: 2.40.70.10 2.40.70.10
4i0e
Design and synthesis of thiophene dihydroisoquinolins as nov inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149
Chain: A (393 residues) CATH domains: 2.40.70.10 2.40.70.10
4i0f
Design and synthesis of thiophene dihydroisoquinolins as nov inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (393 residues) CATH domains: 2.40.70.10 2.40.70.10
4i0g
Design and synthesis of thiophene dihydroisoquinolins as nov inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (393 residues) CATH domains: 2.40.70.10 2.40.70.10
4i0h
Spr and structural analysis yield insight towards mechanism inhibition of bace inhibitors.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (374 residues) CATH domains: 2.40.70.10 2.40.70.10
4i0i
Spr and structural analysis yield insight towards mechanism inhibition of bace inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (372 residues) CATH domains: 2.40.70.10 2.40.70.10
4i0j
Spr and structural analysis yield insight towards mechanism inhibition of bace inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (388 residues) CATH domains: 2.40.70.10 2.40.70.10
4i0z
Structure-based design of novel dihydroisoquinoline bace-1 i that do not engage the catalytic aspartates
Source: Synthetic: yes
Chain: A (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4i10
Structure-based design of novel dihydroisoquinoline bace-1 i that do not engage the catalytic aspartates
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (390 residues) CATH domains: 2.40.70.10 2.40.70.10
4i11
Structure-based design of novel dihydroisoquinoline bace-1 i that do not engage the catalytic aspartates.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (397 residues) CATH domains: 2.40.70.10 2.40.70.10
4i12
Design and synthesis of thiophene dihydroisoquinolins as nov inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
4i1c
Design and synthesis of thiophene dihydroisoquinolins as nov inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (378 residues) CATH domains: 2.40.70.10 2.40.70.10
4ivs
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
4ivt
Crystal structure of bace1 with its inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4j0p
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((s)-2-amino-4-methyl-5,6-dihydro-4h-[1, 4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (376 residues) CATH domains: 2.40.70.10 2.40.70.10
4j0t
Crystal structure of bace-1 in complex with 5-ethoxy-pyridin carboxylic acid [3-((r)-2-amino-5,5-difluoro-4-methyl-5,6-d [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (381 residues) CATH domains: 2.40.70.10 2.40.70.10
4j0v
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((4r,5r)-2-amino-5-fluoro-4-methyl-5,6-d [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
4j0y
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((4r,5s)-2-amino-5-fluoro-4-methyl-5,6-d [1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
4j0z
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((4s,5r)-2-amino-5-fluoro-4-fluoromethyl dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (381 residues) CATH domains: 2.40.70.10 2.40.70.10
4j17
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((s)-2-amino-4-difluoromethyl-5,6-dihydr 3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
4j1c
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((s)-2-amino-5,5-difluoro-4-fluoromethyl dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
4j1e
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((4s,6s)-2-amino-4-fluoromethyl-6-triflu 5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (379 residues) CATH domains: 2.40.70.10 2.40.70.10
4j1f
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((4s,6s)-2-amino-4-methyl-6-trifluoromet dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (376 residues) CATH domains: 2.40.70.10 2.40.70.10
4j1h
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((4s,6r)-2-amino-4-methyl-6-trifluoromet dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (370 residues) CATH domains: 2.40.70.10 2.40.70.10
4j1i
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((4r,5r,6r)-2-amino-5-fluoro-4-methyl-6- trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-p amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (371 residues) CATH domains: 2.40.70.10 2.40.70.10
4j1k
Crystal structure of bace-1 in complex with 5-cyano-pyridine carboxylic acid [3-((4r,5r,6s)-2-amino-5-fluoro-4-methyl-6- trifluoromethyl-5,6-dihydro-4h-[1,3]oxazin-4-yl)-4-fluoro-p amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (368 residues) CATH domains: 2.40.70.10 2.40.70.10
4joo
Spirocyclic beta-site amyloid precursor protein cleaving enz (bace1) inhibitors
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Chain: A (402 residues) CATH domains: 2.40.70.10 2.40.70.10
4jp9
Spirocyclic beta-site amyloid precursor protein cleaving enz (bace1) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (402 residues) CATH domains: 2.40.70.10 2.40.70.10
4jpc
Spirocyclic beta-site amyloid precursor protein cleaving enz (bace1) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (402 residues) CATH domains: 2.40.70.10 2.40.70.10
4jpe
Spirocyclic beta-site amyloid precursor protein cleaving enz (bace1) inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (402 residues) CATH domains: 2.40.70.10 2.40.70.10
4k8s
Hydroxyethylamine-based inhibitors of bace1: p1-p3 macrocycl can improve potency, selectivity, and cell activity
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (371 residues) CATH domains: 2.40.70.10 2.40.70.10
4k9h
Bace-1 inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (370 residues) CATH domains: 2.40.70.10 2.40.70.10
4ke0
Crystal structure of bace1 in complex with hydroxyethylamine macrocyclic inhibitor 13
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (375 residues) CATH domains: 2.40.70.10 2.40.70.10
4ke1
Crystal structure of bace1 in complex with hydroxyethylamine macrocyclic inhibitor 19
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (355 residues) CATH domains: 2.40.70.10 2.40.70.10
4l7g
Diethylaminosulfur trifluoride-mediated intramolecular cycli 2-hydroxy-benzylureas to fused bicyclic aminooxazoline comp evaluation of their biochemical activity against beta-secre (bace1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (373 residues) CATH domains: 2.40.70.10 2.40.70.10
4l7h
Diethylaminosulfur trifluoride-mediated intramolecular cycli 2-hydroxy-benzylureas to fused bicyclic aminooxazoline comp evaluation of their biochemical activity against beta-secre (bace-1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
4l7j
Diethylaminosulfur trifluoride-mediated intramolecular cycli 2-hydroxy-benzylureas to fused bicyclic aminooxazoline comp evaluation of their biochemical activity against beta-secre (bace-1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (374 residues) CATH domains: 2.40.70.10 2.40.70.10
4lc7
Aminooxazoline inhibitor of bace-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (402 residues) CATH domains: 2.40.70.10 2.40.70.10
4lxa
Crystal structure of human beta secretase in complex with co
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (376 residues) CATH domains: 2.40.70.10 2.40.70.10
4lxk
Crystal structure of human beta secretase in complex with co
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (376 residues) CATH domains: 2.40.70.10 2.40.70.10
4lxm
Crystal structure of human beta secretase in complex with co
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace, bace1, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (377 residues) CATH domains: 2.40.70.10 2.40.70.10
4n00
Discovery of 7-thp chromans: bace1 inhibitors that reduce a- the cns
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (393 residues) CATH domains: 2.40.70.10 2.40.70.10
4pzw
Synthesis, characterization and pk/pd studies of a series of spirocyclic pyranochromene bace1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (397 residues) CATH domains: 2.40.70.10 2.40.70.10
4pzx
Synthesis, characterization and pk/pd studies of a series of spirocyclic pyranochromene bace1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bace1, bace, kiaa1149. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (400 residues) CATH domains: 2.40.70.10 2.40.70.10