_EC 3.4.22.69 Sars coronavirus main proteinase. 130 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.22.- Cysteine endopeptidases. [986 PDB entries]
EC 3.4.22.69 Sars coronavirus main proteinase. [130 PDB entries]    
1q2w

Reaction: Tsavlq-|-SGFRK-NH(2) and sgvtfq-|-gkfkk the two peptides corresponding to the two self-cleavage sites of the Sars 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position.
Other name(s): 3C-like protease. 3cLpro. Coronavirus 3C-like protease. Sars coronavirus main protease. SARS-CoV 3CLpro enzyme. Severe acute respiratory syndrome coronavirus main protease.
Comments: Sars coronavirus main protease is the key enzyme in sars coronavirus replicase polyprotein processing. Belongs to peptidase family C30.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 130 PDB entries in enzyme class E.C.3.4.22.69

  PDB code Protein
1q2w
X-ray crystal structure of the sars coronavirus main protease
Source: Sars coronavirus. Organism_taxid: 227859. Strain: urbani. Gene: orf1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (295 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
1qz8
Crystal structure of sars coronavirus nsp9
Source: Sars coronavirus. Organism_taxid: 227859. Strain: frankfurt 1. Gene: nsp9. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (111 residues) CATH domain: 2.40.10.250
1uj1
Crystal structure of sars coronavirus main proteinase (3clpro)
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
1uk2
Crystal structure of sars coronavirus main proteinase (3clpro) at ph8.0
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (302 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
1uk3
Crystal structure of sars coronavirus main proteinase (3clpro) at ph7.6
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
1uk4
Crystal structure of sars coronavirus main proteinase (3clpro) complexed with an inhibitor
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the sequence occurs peptide synthesis
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
1uw7
Nsp9 protein from sars-coronavirus.
Source: Sars coronavirus hku-39849. Organism_taxid: 228404. Cell_line: vero e6. Expressed in: e. Coli.
Chain: A (122 residues) CATH domain: 2.40.10.250
1wof
Crystal structure of sars-cov mpro in complex with an inhibitor n1
Source: Sars coronavirus. Organism_taxid: 227859. Strain: bj01. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (309 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
1ysy
Nmr structure of the nonstructural protein 7 (nsp7) from the sars coronavirus
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (85 residues) CATH domain: Unassigned
1z1i
Crystal structure of native sars clpro
Source: Sars coronavirus. Organism_taxid: 227859
Chain: A (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
1z1j
Crystal structure of sars 3clpro c145a mutant
Source: Sars coronavirus. Organism_taxid: 227859
Chains: A, B (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2a5a
Crystal structure of unbound sars coronavirus main peptidase in the space group c2
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2a5i
Crystal structures of sars coronavirus main peptidase inhibi aza-peptide epoxide in the space group c2
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2a5k
Crystal structures of sars coronavirus main peptidase inhibited by an aza-peptide epoxide in space group p212121
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (304 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2acf
Nmr structure of sars-cov non-structural protein nsp3a (sars sars coronavirus
Source: Sars coronavirus tor2. Organism_taxid: 227984. Strain: tor-2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (172 residues) CATH domain: 3.40.220.10
2ahm
Crystal structure of sars-cov super complex of non-structura proteins: the hexadecamer
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (77 residues) CATH domain: Unassigned
2alv
X-ray structural analysis of sars coronavirus 3cl proteinase in complex with designed anti-viral inhibitors
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (302 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2amd
Crystal structure of sars_cov mpro in complex with an inhibitor n9
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (309 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2amq
Crystal structure of sars_cov mpro in complex with an inhibitor n3
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (303 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2bx3
Crystal structure of sars coronavirus main proteinase (p43212)
Source: Sars coronavirus sin2774. Organism_taxid: 235410. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (300 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2bx4
Crystal structure of sars coronavirus main proteinase (p21212)
Source: Sars coronavirus sin2774. Organism_taxid: 235410. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (298 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2c3s
Structure of sars cov main proteinase at 1.9 a (ph6.5)
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sin2774. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (302 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2d2d
Crystal structure of sars-cov mpro in complex with an inhibitor i2
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2duc
Crystal structure of sars coronavirus main proteinase(3clpro)
Source: Sars coronavirus. Organism_taxid: 227859. Other_details: cell-free protein synthesis
Chains: A, B (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2fav
Crystal structure of sars macro domain in complex with adp- ribose at 1.8 a resolution
Source: Sars coronavirus. Organism_taxid: 227859. Strain: frankfurt 1. Gene: nsp3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (172 residues) CATH domain: 3.40.220.10
2fe8
Sars coronavirus papain-like protease: structure of a viral deubiquitinating enzyme
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C (315 residues) CATH domains: Unassigned Unassigned Unassigned
2fyg
Crystal structure of nsp10 from sars coronavirus
Source: Sars coronavirus. Organism_taxid: 227859. Strain: tor-2. Gene: orf1ab. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (128 residues) CATH domain: Unassigned
2g9t
Crystal structure of the sars coronavirus nsp10 at 2.1a
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (118 residues) CATH domain: Unassigned
2ga6
The crystal structure of sars nsp10 without zinc ion as additive
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (118 residues) CATH domain: Unassigned
2gdt
Nmr structure of the nonstructural protein 1 (nsp1) from the sars coronavirus
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (116 residues) CATH domain: Unassigned
2gri
Nmr structure of the sars-cov non-structural protein nsp3a
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (112 residues) CATH domain: Unassigned
2gt7
Crystal structure of sars coronavirus main peptidase at ph 6 space group p21
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (300 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2gt8
Crystal structure of sars coronavirus main peptidase (with a additional ala at the n-terminus of each protomer) in the s p43212
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (298 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2gtb
Crystal structure of sars coronavirus main peptidase (with a additional ala at the n-terminus of each protomer) inhibite aza-peptide epoxide in the space group p43212
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (299 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2gx4
Crystal structure of sars coronavirus 3cl protease inhibitor
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2gz7
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of sars-cov main protease
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2gz8
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of sars-cov main protease
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2gz9
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of sars-cov main protease
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2h2z
Crystal structure of sars-cov main protease with authentic n and c-termini
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2h85
Crystal structure of nsp 15 from sars
Source: Sars coronavirus. Organism_taxid: 227859. Strain: frankfurt-1. Gene: nsp15. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (347 residues) CATH domains: Unassigned Unassigned Unassigned
2hob
Crystal structure of sars-cov main protease with authentic n and c-termini in complex with a michael acceptor n3
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2hsx
Nmr structure of the nonstructural protein 1 (nsp1) from the sars coronavirus
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (116 residues) CATH domain: Unassigned
2idy
Nmr structure of the sars-cov non-structural protein nsp3a
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (112 residues) CATH domain: Unassigned
2jzd
Nmr structure of the domain 527-651 of the sars-cov nonstructural protein nsp3
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep, 1a-1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (129 residues) CATH domain: Unassigned
2jze
Nmr structure of the domain 527-651 of the sars-cov nonstructural protein nsp3, single conformer closest to the mean coordinates of an ensemble of twenty energy minimized conformers
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep, 1a-1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (129 residues) CATH domain: Unassigned
2jzf
Nmr conformer closest to the mean coordinates of the domain the sars-cov nonstructural protein nsp3
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep, 1a-1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (143 residues)
2k87
Nmr structure of a putative RNA binding protein (sars1) from coronavirus
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (116 residues)
2kaf
Solution structure of the sars-unique domain-c from the nons protein 3 (nsp3) of the severe acute respiratory syndrome c
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (67 residues) CATH domain: Unassigned
2kqv
Sars coronavirus-unique domain (sud): three-domain molecular architecture in solution and RNA binding. I: structure of t domain of sud-mc
Source: Sars coronavirus. Organism_taxid: 227859. Strain: tor2. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (129 residues)
2kqw
Sars coronavirus-unique domain (sud): three-domain molecular architecture in solution and RNA binding. Ii: structure of domain of sud-mc
Source: Sars coronavirus. Organism_taxid: 227859. Strain: tor2. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (67 residues)
2kys
Nmr structure of the sars coronavirus nonstructural protein solution at ph 6.5
Source: Sars coronavirus. Organism_taxid: 227859. Strain: tor2. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (85 residues) CATH domain: Unassigned
2liz
Nmr solution structure of c-terminal domain of sars-cov main in 2.5m urea
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (120 residues) CATH domain: 1.10.1840.10
2m0a
Solution structure of mhv nsp3a
Source: Murine hepatitis virus. Organism_taxid: 11142. Strain: a59. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (114 residues) CATH domain: Unassigned
2op9
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the sars coronavirus
Source: Sars coronavirus. Organism_taxid: 227859. Strain: tor2. Gene: 3clpro. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (302 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2ozk
Structure of an n-terminal truncated form of nendou (nsp15) from sars-coronavirus
Source: Sars coronavirus. Organism_taxid: 227859. Strain: tor-2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (306 residues) CATH domains: Unassigned Unassigned Unassigned
2pwx
Crystal structure of g11a mutant of sars-cov 3c-like proteas
Source: Sars coronavirus. Organism_taxid: 228407. Strain: bj01. Gene: rep. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (289 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2q6g
Crystal structure of sars-cov main protease h41a mutant in c with an n-terminal substrate
Source: Sars coronavirus. Organism_taxid: 228407. Strain: bj01. Gene: rep. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Synthetic: yes. Other_details: chemically synthesized.
Chains: A, B (305 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2qc2
Crystal structure of severe acute respiratory syndrome (sars protease asn214ala mutant
Source: Sars coronavirus. Virus. Gene: rep. Expressed in: escherichia coli.
Chains: A, B (305 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2qcy
Crystal structure of a monomeric form of severe acute respiratory syndrome (sars) 3c-like protease mutant
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2qiq
Structure-based design and synthesis and biological evaluation of peptidomimetic sars-3clpro inhibitors
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2rhb
Crystal structure of nsp15-h234a mutant- hexamer in asymmetric unit
Source: Sars coronavirus. Organism_taxid: 227859. Strain: urbani isolate of sars-cov. Gene: nsp15. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 star.
Chains: A, B, C, D, E, F (345 residues) CATH domains: Unassigned Unassigned Unassigned
2rnk
Nmr structure of the domain 513-651 of the sars-cov nonstructural protein nsp3
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep, 1a-1b. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (143 residues) CATH domain: Unassigned
2v6n
Crystal structures of the sars-coronavirus main proteinase inactivated by benzotriazole compounds
Source: Human sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2w2g
Human sars coronavirus unique domain
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (257 residues) CATH domains: Unassigned Unassigned
2wct
Human sars coronavirus unique domain (triclinic form)
Source: Sars coronavirus. Organism_taxid: 227859. Strain: sars-cov. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (257 residues) CATH domains: Unassigned Unassigned
2xyq
Crystal structure of the nsp16 nsp10 sars coronavirus comple
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (287 residues) CATH domain: Unassigned
2xyr
Crystal structure of the nsp16 nsp10 sars coronavirus comple
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (286 residues) CATH domain: Unassigned
2xyv
Crystal structure of the nsp16 nsp10 sars coronavirus comple
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (285 residues) CATH domain: Unassigned
2yna
Crystal structure of the main protease of coronavirus hku4
Source: Tylonycteris bat coronavirus hku4. Organism_taxid: 694007. Strain: hku4-1l. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold
Chains: A, B (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2ynb
Crystal structure of the main protease of coronavirus hku4 in complex with a michael acceptor sg85
Source: Tylonycteris bat coronavirus hku4. Organism_taxid: 694007. Strain: hku4-1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: gold
Chains: A, B (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2yy4
Crystal structure of ms8104
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: cell-free protein synthesis.
Chains: A, B (310 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2z3c
A mechanistic view of enzyme inhibition and peptide hydrolys active site of the sars-cov 3c-like peptidase
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2z3d
A mechanistic view of enzyme inhibition and peptide hydrolys active site of the sars-cov 3c-like peptidase
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: rep. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2z3e
A mechanistic view of enzyme inhibition and peptide hydrolys active site of the sars-cov 3c-like peptidase
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2z94
Complex structure of sars-cov 3c-like protease with tdt
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2z9g
Complex structure of sars-cov 3c-like protease with pma
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2z9j
Complex structure of sars-cov 3c-like protease with epdtc
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (302 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2z9k
Complex structure of sars-cov 3c-like protease with jmf1600
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (305 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2z9l
Complex structure of sars-cov 3c-like protease with jmf1586
Source: Sars coronavirus. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (300 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2zu4
Complex structure of sars-cov 3cl protease with tg-0204998
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
2zu5
Complex structure of sars-cov 3cl protease with tg-0205486
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3atw
Structure-based design, synthesis, evaluation of peptide-mim 3cl protease inhibitors
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was designed and chemically synt
Chains: A, B (300 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3avz
Structure of sars 3cl protease with peptidic aldehyde inhibi containing cyclohexyl side chain
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: A (300 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3aw0
Structure of sars 3cl protease with peptidic aldehyde inhibi
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3aw1
Structure of sars 3cl protease auto-proteolysis resistant mu the absent of inhibitor
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3d62
Development of broad-spectrum halomethyl ketone inhibitors a coronavirus main protease 3clpro
Source: Sars coronavirus. Organism_taxid: 227859. Gene: rep. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (299 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3e91
Crystal structure of sars-cov mpro mutant in p21 at ph6.9
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (305 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3e9s
A new class of papain-like protease/deubiquitinase inhibitors blocks sars virus replication
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (317 residues) CATH domains: Unassigned Unassigned Unassigned
3ea7
Crystal structure of sars-cov main protease triple mutant sti/a in space group p21
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (305 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3ea8
Crystal structure of sars-cov main protease triple mutant sti/a in space group c2
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3ea9
Crystal structure of sars-cov main protease quadruple mutant stif/a with one molecule in one asymmetric unit
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3eaj
Crystal structure of sars-cov main protease quadruple mutant stif/a with two molecules in one asymmetric unit
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (302 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3ebn
A special dimerization of sars-cov main proteasE C-terminal domain due to domain-swapping
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: rep, 1a-1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (100 residues) CATH domain: 1.10.1840.10
3ee7
Crystal structure of sars-cov nsp9 g104e
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Strain: urbani. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (106 residues) CATH domain: 2.40.10.250
3f9e
Crystal structure of the s139a mutant of sars-coronovirus 3c-like protease
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Strain: bj01. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (297 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3f9f
Crystal structure of the f140a mutant of sars-coronovirus 3c-like protease at ph 6.0
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Strain: bj01. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (299 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3f9g
Crystal structure of the f140a mutant of sars-coronovirus 3c-like protease at ph 6.5
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Strain: bj01. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (297 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3f9h
Crystal structure of the f140a mutant of sars-coronovirus 3c-like protease at ph 7.6
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Strain: bj01. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (299 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3fzd
Mutation of asn28 disrupts the enzymatic activity and dimeri sars 3clpro
Source: Sars coronavirus. Virus. Organism_taxid: 227859. Strain: tor2. Gene: 1a, sars 3cl protease. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (296 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3iwm
The octameric sars-cov main protease
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3m3s
Crystal structure of sars-cov main protease asn214ala mutant authorize n-terminus
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: main protease. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3m3t
Sars-cov main protease monomeric arg298ala mutant with n-ter additional residues (gly-ser)
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (307 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3m3v
Sars-cov main protease triple mutant sti/a with two n-termin additional residue (gly-ser)
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3mj5
Severe acute respiratory syndrome-coronavirus papain-like pr inhibitors: design, synthesis, protein-ligand x-ray structu biological evaluation
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Strain: urbani. Gene: 1a, orf1 (nsp3) residues 1544-1855. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (312 residues) CATH domains: Unassigned Unassigned Unassigned
3r24
Crystal structure of nsp10/nsp16 complex of sars coronavirus possible
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: rep, 1a-1b. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: 1a.
Chains: A, B (292 residues) CATH domain: Unassigned
3sn8
Crystal structure of sars coronavirus main protease complexe ff-h (soaking)
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3sna
Crystal structure of sars coronavirus main protease complexe nsfsq-h (soaking)
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3snb
Crystal structure of sars coronavirus main protease complexe dsfdq-h (soaking)
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3snc
Crystal structure of sars coronavirus main protease complexe nstsq-h (soaking)
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3snd
Crystal structure of sars coronavirus main protease complexe estlq-h (cocrystallization)
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3sne
Crystal structure of sars coronavirus main protease complexe estlq-h (soaking)
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3szn
Crystal structure of sars coronavirus main protease complexe alpha, beta-unsaturated ethyl ester sg75
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3tit
Crystal structure of sars coronavirus main protease complexe alpha, beta-unsaturated ethyl ester sg81
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3tiu
Crystal structure of sars coronavirus main protease complexe alpha,beta-unsaturated ethyl ester inhibitor sg82
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3tns
Crystal structure of sars coronavirus main protease complexe alpha, beta-unsaturated ethyl ester inhibitor sg83
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3tnt
Crystal structure of sars coronavirus main protease complexe alpha, beta-unsaturated ethyl ester inhibitor sg85
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3v3m
Severe acute respiratory syndrome coronavirus (sars-cov) 3cl in complex with n-[(1r)-2-(tert-butylamino)-2-oxo-1-(pyridi ethyl]-n-(4-tert-butylphenyl)furan-2-carboxamide inhibitor.
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: homo sapiens. Expression_system_taxid: 9606
Chain: A (306 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3vb3
Crystal structure of sars-cov 3c-like protease in apo form
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3vb4
Crystal structure of sars-cov 3c-like protease with b4z
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic inhibitor
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3vb5
Crystal structure of sars-cov 3c-like protease with c4z
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic inhibitor
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3vb6
Crystal structure of sars-cov 3c-like protease with c6z
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic inhibitor
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3vb7
Crystal structure of sars-cov 3c-like protease with m4z
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic inhibitor
Chains: A, B (301 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
3vc8
Crystal structure of thE C-terminal cytoplasmic domain of no structural protein 4 from mouse hepatitis virus a59
Source: Murine hepatitis virus. Organism_taxid: 591071. Strain: a59. Gene: murine hepatitis virus strain a59 orf1ab, orf1a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (81 residues) CATH domain: Unassigned
3vcb
C425s mutant of thE C-terminal cytoplasmic domain of non-str protein 4 from mouse hepatitis virus a59
Source: Murine hepatitis virus. Organism_taxid: 591071. Strain: a59. Gene: murine hepatitis virus strain a59 orf1ab, orf1a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (89 residues) CATH domain: Unassigned
4hi3
Crystal structure of dimeric r298a mutant of sars coronaviru protease
Source: Sars coronavirus. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (300 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
4m0w
Crystal structure of sars-cov papain-like protease c112s mut complex with ubiquitin
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a, nsp3. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Bovine. Organism_taxid: 9913.
Chain: A (317 residues) CATH domains: Unassigned Unassigned Unassigned
4mds
Discovery of n-(benzo[1,2,3]triazol-1-yl)-n-(benzyl)acetamid carboxamides as severe acute respiratory syndrome coronavir cov) 3clpro inhibitors: identification of ml300 and non-cov nanomolar inhibitors with an induced-fit binding
Source: Sars coronavirus. Sars-cov. Organism_taxid: 227859. Gene: 1a. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (303 residues) CATH domains: 2.40.10.10 2.40.10.10 1.10.1840.10
4mm3
Crystal structure of sars-cov papain-like protease plpro in with ubiquitin aldehyde
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ubc. Expressed in: escherichia coli. Expression_system_taxid: 562. Sars coronavirus. Sars-cov. Organism_taxid: 227859.
Chain: B (316 residues) CATH domains: Unassigned Unassigned Unassigned
4ovz
X-ray structural and biological evaluation of a series of po highly selective inhibitors of human coronavirus papain-lik proteases
Source: Sars coronavirus. Organism_taxid: 228330. Strain: urbani. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (305 residues) CATH domains: Unassigned Unassigned Unassigned
4ow0
X-ray structural and biological evaluation of a series of po highly selective inhibitors of human coronavirus papain-lik proteases
Source: Sars coronavirus. Organism_taxid: 228330. Strain: urbani. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (312 residues) CATH domains: Unassigned Unassigned Unassigned