_EC 3.4.22.65 Peptidase 1 (mite). 6 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.22.- Cysteine endopeptidases. [986 PDB entries]
EC 3.4.22.65 Peptidase 1 (mite). [6 PDB entries]    
1xkg

Reaction: Broad endopeptidase specificity.
Other name(s): Allergen Der p 1. Endopeptidase 1 (mite). Major mite fecal allergen Der p 1.
Comments: This enzyme, derived from the house dust mite, is a major component of the allergic immune response. The substrate specificity of this enzyme is not altogether clear; it cleaves the low-affinity IgE receptor CD23 at 298-Glu-|-Ser-299 and 155-Ser-|-Ser-156. It also cleaves the pulmonary structural proteins occludin and claudin at Leu-|-Leu, Asp-|-Leu and at Gly-|-Thr bonds, and it can also cleave the alpha subunit of the interleukin-2 (IL-2) receptor (CD25). Using a positional scanning combinatorial library, it was found that
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There are 6 PDB entries in enzyme class E.C.3.4.22.65

  PDB code Protein
1xkg
Crystal structure of the major house dust mite allergen der pro form at 1.61 a resolution
Source: Dermatophagoides pteronyssinus. European house dust mite. Organism_taxid: 6956. Gene: derp1. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (298 residues) CATH domain: 3.90.70.10
2as8
Crystal structure of mature and fully active der p 1 allergen
Source: Dermatophagoides pteronyssinus. European house dust mite. Organism_taxid: 6956. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (222 residues) CATH domain: 3.90.70.10
3d6s
Crystal structure of mite allergen der f 1
Source: Dermatophagoides farinae. House-dust mite. Organism_taxid: 6954
Chains: A, B, C (223 residues) CATH domain: 3.90.70.10
3rvv
Crystal structure of der f 1 complexed with fab 4c1
Source: Dermatophagoides farinae. American house dust mite. Organism_taxid: 6954. Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: hybridoma.
Chain: A (223 residues) CATH domain: 3.90.70.10
3rvw
Crystal structure of der p 1 complexed with fab 4c1
Source: Dermatophagoides pteronyssinus. European house dust mite. Organism_taxid: 6956. Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: hybridoma.
Chain: A (222 residues) CATH domain: 3.90.70.10
3rvx
Crystal structure of der p 1 complexed with fab 4c1
Source: Dermatophagoides pteronyssinus. European house dust mite. Organism_taxid: 6956. Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: mus musculus. Expression_system_taxid: 10090. Expression_system_cell_line: hybridoma.
Chain: A (222 residues) CATH domain: 3.90.70.10