_EC 3.4.22.53 Calpain-2. 9 PDB entries  
EC 3.-.-.- Hydrolases. [20,839 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,819 PDB entries]
EC 3.4.22.- Cysteine endopeptidases. [978 PDB entries]
EC 3.4.22.53 Calpain-2. [9 PDB entries]    
1df0

Reaction: Broad endopeptidase specificity.
Other name(s): Calcium-activated neutral protease Ii. M-calpain. Milli-calpain.
Cofactor(s): Calcium.
Comments: Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of Ec 3.4.22.52. Belongs to peptidase family C2. Formerly Ec 3.4.22.17 and Ec 3.4.24.5.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 9 PDB entries in enzyme class E.C.3.4.22.53

  PDB code Protein
1df0
Crystal structure of m-calpain
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: A (624 residues) CATH domains: Unassigned 3.90.70.10 2.60.120.380 1.10.238.10
1kfu
Crystal structure of human m-calpain form ii
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_taxid: 7108
Chain: L (699 residues) CATH domains: Unassigned 3.90.70.10 2.60.120.380 1.10.238.10
1kfx
Crystal structure of human m-calpain form i
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_taxid: 7108
Chain: L (640 residues) CATH domains: Unassigned 3.90.70.10 2.60.120.380 1.10.238.10
1mdw
Crystal structure of calcium-bound protease core of calpain ii reveals the basis for intrinsic inactivation
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: calpain ii. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (319 residues) CATH domains: Unassigned 3.90.70.10
1qxp
Crystal structure of a mu-like calpain
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (783 residues) CATH domains: Unassigned 3.90.70.10 2.60.120.380 1.10.238.10 1.10.238.10
1u5i
Crystal structure analysis of rat m-calpain mutant lys10 thr
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: A (625 residues) CATH domains: Unassigned 3.90.70.10 2.60.120.380 1.10.238.10
2nqa
Catalytic domain of human calpain 8
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: loc388743. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: commercially available from sigma l2884
Chain: A (310 residues) CATH domains: Unassigned 3.90.70.10
3bow
Structure of m-calpain in complex with calpastatin
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: capn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: capns1, capn4, css1. Gene: cast.
Chain: A (680 residues) CATH domains: Unassigned 3.90.70.10 2.60.120.380 1.10.238.10
3df0
Calcium-dependent complex between m-calpain and calpastatin
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: capn2. Expressed in: escherichia coli. Gene: capns1, capn4, css1. Gene: cast.
Chain: A (676 residues) CATH domains: Unassigned 3.90.70.10 2.60.120.380 1.10.238.10