_EC 3.4.22.52 Calpain-1. 12 PDB entries  
EC 3.-.-.- Hydrolases. [20,887 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,819 PDB entries]
EC 3.4.22.- Cysteine endopeptidases. [974 PDB entries]
EC 3.4.22.52 Calpain-1. [12 PDB entries]    
1kxr

Reaction: Broad endopeptidase specificity.
Other name(s): Calcium-activated neutral protease I. Mu-calpain.
Cofactor(s): Calcium.
Comments: Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of Ec 3.4.22.53. Belongs to peptidase family C2. Formerly Ec 3.4.22.17 and Ec 3.4.24.5.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 12 PDB entries in enzyme class E.C.3.4.22.52

  PDB code Protein
1kxr
Crystal structure of calcium-bound protease core of calpain i
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: capn1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (320 residues) CATH domains: Unassigned 3.90.70.10
1qxp
Crystal structure of a mu-like calpain
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (783 residues) CATH domains: Unassigned 3.90.70.10 2.60.120.380 1.10.238.10 1.10.238.10
1tl9
High resolution crystal structure of calpain i protease core complex with leupeptin
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: capn1, cls1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes
Chain: A (321 residues) CATH domains: Unassigned 3.90.70.10
1tlo
High resolution crystal structure of calpain i protease core in complex with e64
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: capn1, cls1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (322 residues) CATH domains: Unassigned 3.90.70.10
1zcm
Human calpain protease core inhibited by zllych2f
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: capn1, canpl1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (321 residues) CATH domains: Unassigned 3.90.70.10
2ary
Catalytic domain of human calpain-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: capn1, canpl1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (322 residues) CATH domains: Unassigned 3.90.70.10
2g8e
Calpain 1 proteolytic core in complex with snj-1715, a cycli hemiacetal-type inhibitor
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: capn1, cls1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (326 residues) CATH domains: Unassigned 3.90.70.10
2g8j
Calpain 1 proteolytic core in complex with snj-1945, a alpha-ketoamide-type inhibitor.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: capn1, cls1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (322 residues) CATH domains: Unassigned 3.90.70.10
2nqg
Calpain 1 proteolytic core inactivated by wr18(s,s), an epoxysuccinyl-type inhibitor.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: capn1, cls1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (322 residues) CATH domains: Unassigned 3.90.70.10
2nqi
Calpain 1 proteolytic core inactivated by wr13(r,r), an epoxysuccinyl-type inhibitor.
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: capn1, cls1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (322 residues) CATH domains: Unassigned 3.90.70.10
2r9c
Calpain 1 proteolytic core inactivated by zlak-3001, an alph ketoamide
Source: Rattus norvegicus. Rat. Gene: capn1, cls1. Expressed in: escherichia coli.
Chain: A (322 residues) CATH domains: Unassigned 3.90.70.10
2r9f
Calpain 1 proteolytic core inactivated by zlak-3002, an alph ketoamide
Source: Rattus norvegicus. Rat. Gene: capn1, cls1. Expressed in: escherichia coli.
Chain: A (322 residues) CATH domains: Unassigned 3.90.70.10