_EC 3.4.22.46 L-peptidase. 15 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.22.- Cysteine endopeptidases. [986 PDB entries]
EC 3.4.22.46 L-peptidase. [15 PDB entries]    
1bcv

Reaction: Autocatalytically cleaves itself from the polyprotein of the foot- and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
Comments: Best known from foot-and-mouth disease virus, but occurs in other aphthoviruses and cardioviruses. Destruction of initiation factor eIF-4G has the effect of shutting off host-cell protein synthesis while allowing synthesis of viral proteins to continue. The tertiary structure reveals a distant relationship to papain and, consistent with this, compound E-64 is inhibitory. Belongs to peptidase family C28.
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There are 15 PDB entries in enzyme class E.C.3.4.22.46

  PDB code Protein
1bcv
Synthetic peptide corresponding to the major immunogen site of fmd virus, nmr, 10 structures
Source: not given
Chain: A (20 residues)
1ejo
Fab fragment of neutralising monoclonal antibody 4c4 complexed with g-h loop from fmdv.
Source: Mus musculus. House mouse. Organism_taxid: 10090. Synthetic: yes. Other_details: this synthetic peptide corresponds to the sequence of the g-h loop from foot-and-mouth disease virus.
Chain: P (13 residues)
1fmd
The structure and antigenicity of a typE C foot-and-mouth disease virus
Source: Foot-and-mouth disease virus. Organism_taxid: 12110. Organ: kidney. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_taxid: 10036
Chains: 2, 3, 4 (218 residues) CATH domain: 2.60.120.20
1qgc
Structure of the complex of an fab fragment of a neutralizin with foot and mouth disease virus
Source: Foot-and-mouth disease virus - typE C. Organism_taxid: 12116. Strain: serotypE C. Mus musculus. House mouse. Organism_taxid: 10090. Strain: serotypE C
Chains: 1, 2, 3, 5 (183 residues)
1qmy
Fmdv leader protease (lbshort-c51a-c133s)
Source: Aphthovirus o. Foot-and-mouth disease virus, fmdv. Organism_taxid: 12118. Strain: o1k. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (156 residues) CATH domain: 3.90.70.10
1qol
Structure of the fmdv leader protease
Source: Foot-and-mouth disease virus. Organism_taxid: 73482. Strain: o1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F, G, H (166 residues) CATH domain: 3.90.70.10
1qqp
Foot-and-mouth disease virus/ oligosaccharide receptor compl
Source: Foot-and-mouth disease virus. Organism_taxid: 12110. Other_details: grown in bhk cells. Other_details: grown in bhk cells
Chains: 1, 2, 3, 4 (188 residues) CATH domain: 2.60.120.20
1zba
Foot-and-mouth disease virus serotype a1061 complexed with oligosaccharide receptor.
Source: Foot-and-mouth disease virus. Organism_taxid: 12110. Organism_taxid: 12110
Chains: 1, 2, 3, 4 (191 residues) CATH domain: 2.60.120.20
1zbe
Foot-and mouth disease virus serotype a1061
Source: Foot-and-mouth disease virus. Organism_taxid: 12110. Organism_taxid: 12110
Chains: 1, 2, 3, 4 (191 residues) CATH domain: 2.60.120.20
2bhg
3c protease from type a10(61) foot-and-mouth disease virus
Source: Foot-and-mouth disease virus. Fmdv. Organism_taxid: 12110. Strain: a10(61). Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (194 residues) CATH domains: 2.40.10.10 2.40.10.10
2j92
3c protease from type a10(61) foot-and-mouth disease virus- crystal packing mutant (k51q)
Source: Foot-and-mouth disease virus (strain a10-61). Organism_taxid: 12112. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (201 residues) CATH domains: 2.40.10.10 2.40.10.10
2jqf
Full length leader protease of foot and mouth disease virus c51a mutant
Source: Foot-and-mouth disease virus (strain o1). Organism_taxid: 73482. Strain: o1. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: (de)plyss.
Chains: R, S (166 residues) CATH domain: 3.90.70.10
2jqg
Leader protease
Source: Foot-and-mouth disease virus (strain o1). Organism_taxid: 73482. Strain: o1. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: (de)plyss.
Chain: R (167 residues) CATH domain: 3.90.70.10
2wv4
Crystal structure of foot-and-mouth disease virus 3c protease in complex with a decameric peptide corresponding to the vp1-2a cleavage junction
Source: Foot-and-mouth disease virus. Organism_taxid: 12112. Strain: a10-61. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Strain: a10-61
Chains: A, B (201 residues) CATH domains: 2.40.10.10 2.40.10.10
2wv5
Crystal structure of foot-and-mouth disease virus 3c protease in complex with a decameric peptide corresponding to the vp1-2a cleavage junction with a gln to glu substitution at p1
Source: Foot-and-mouth disease virus. Organism_taxid: 12112. Strain: a10-61. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Strain: a10-61
Chains: A, B, C, D (200 residues) CATH domains: 2.40.10.10 2.40.10.10