_EC 3.4.22.45 Helper-component proteinase. 5 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.22.- Cysteine endopeptidases. [986 PDB entries]
EC 3.4.22.45 Helper-component proteinase. [5 PDB entries]    
1lvb

Reaction: Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
Other name(s): HC-Pro.
Comments: Known from many potyviruses. The helper component-proteinase of the tobacco etch virus is a multifunctional protein with several known activities. The N-terminal region is required for aphid transmission and efficient genome amplification, the central region is required for long-distance movement in plants, and the C-terminal domain has cysteine endopeptidase activity. Belongs to peptidase family C6.
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There are 5 PDB entries in enzyme class E.C.3.4.22.45

  PDB code Protein
1lvb
Catalytically inactive tobacco etch virus protease complexed substrate
Source: Tobacco etch virus. Organism_taxid: 12227. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (214 residues) CATH domains: 2.40.10.10 2.40.10.10
1lvm
Catalytically active tobacco etch virus protease complexed with product
Source: Tobacco etch virus. Organism_taxid: 12227. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (229 residues) CATH domains: 2.40.10.10 2.40.10.10
1q31
Crystal structure of the tobacco etch virus protease c151a m
Source: Tobacco etch virus. Organism_taxid: 12227. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (227 residues) CATH domains: 2.40.10.10 2.40.10.10
3mmg
Crystal structure of tobacco vein mottling virus protease
Source: Tobacco vein mottling virus. Tvmv. Organism_taxid: 12228. Gene: protease. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: peptide 8mer
Chains: A, B (217 residues) CATH domains: 2.40.10.10 2.40.10.10
3rnv
Structure of the autocatalytic cysteine protease domain of p helper-component proteinase
Source: Turnip mosaic virus. Organism_taxid: 12230. Strain: japanese. Gene: hc-pro. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: Unassigned