_EC 3.4.22.36 Caspase-1. 33 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.22.- Cysteine endopeptidases. [986 PDB entries]
EC 3.4.22.36 Caspase-1. [33 PDB entries]    
1bmq

Reaction: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
Other name(s): Interleukin 1-beta converting enzyme. Interleukin 1-beta-converting endopeptidase. Interleukin-1 beta convertase precursor. Interleukin-1-beta convertase. Pro-interleukin 1-beta proteinase. Prointerleukin 1-beta protease.
Comments: Part of the family of inflammatory-caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Cleaves pro-interleukin-1-beta (pro-IL-1-beta) to form mature IL-1- beta, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 33 PDB entries in enzyme class E.C.3.4.22.36

  PDB code Protein
1bmq
Crystal structure of the complex of interleukin-1beta converting enzyme (ice) with a peptide based inhibitor, (3s )-n-methanesulfonyl-3-({1-[n-(2-naphtoyl)-l-valyl]-l- prolyl }amino)-4-oxobutanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (167 residues) CATH domain: 3.40.50.1460
1ibc
Crystal structure of inhibited interleukin-1beta converting
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: 293. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (167 residues) CATH domain: 3.40.50.1460
1ice
Structure and mechanism of interleukin-1beta converting enzy
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes. Organism_taxid: 9606
Chains: A, B (167 residues) CATH domain: 3.40.50.1460
1rwk
Crystal structure of human caspase-1 in complex with 3-(2-me acetylamino)-4-oxo-pentanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
1rwm
Crystal structure of human caspase-1 in complex with 4-oxo-3 {[4-(quinoxalin-2-ylamino)-benzoylamino]-methyl}-thiophen-2 acetylamino]-pentanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
1rwn
Crystal structure of human caspase-1 in complex with 3-{2-et (quinoxalin-2-ylamino)-benzoylamino]-hexanoylamino}-4-oxo-b acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
1rwo
Crystal structure of human caspase-1 in complex with 4-oxo-3 (quinoxalin-2-ylamino)-benzoylamino]-2-thiophen-2-yl-hexano pentanoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
1rwp
Crystal structure of human caspase-1 in complex with 3-{6-[( quinoline-2-carbonyl)-amino]-2-thiophen-2-yl-hexanoylamino} butyric acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
1rwv
Crystal structure of human caspase-1 in complex with 5-[5-(1 carboxymethyl-2-oxo-propylcarbamoyl)-5-phenyl-pentylsulfamo hydroxy-benzoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
1rww
Crystal structure of human caspase-1 in complex with 4-oxo-3 (quinoxalin-2-ylamino)-benzoylamino]-methyl}-pyridine-3-car amino]-butyric acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (175 residues) CATH domain: 3.40.50.1460
1rwx
Crystal structure of human caspase-1 in complex with 4-oxo-3 (quinoxalin-2-yloxy)-benzoylamino]-2-thiophen-2-yl-hexanoyl butyric acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (178 residues) CATH domain: 3.40.50.1460
1sc1
Crystal structure of an active-site ligand-free form of the caspase-1 c285a mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (167 residues) CATH domain: 3.40.50.1460
1sc3
Crystal structure of the human caspase-1 c285a mutant in com malonate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
1sc4
Crystal structure of the human caspase-1 c285a mutant after malonate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (166 residues) CATH domain: 3.40.50.1460
2fqq
Crystal structure of human caspase-1 (cys285->ala, cys362->a cys364->ala, cys397->ala) in complex with 1-methyl-3-triflu 1h-thieno[2,3-c]pyrazole-5-carboxylic acid (2-mercapto-ethy
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (147 residues) CATH domain: 3.40.50.1460
2fqr
Crystal structure of wildtype human caspase-1 in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)- propionylamino]-4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli.
Chains: A, B (168 residues) CATH domain: 3.40.50.1460
2fqs
Crystal structure of human caspase-1 (arg286->ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl- butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-vad- fmk)
Source: Homo sapiens. Human. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli.
Chains: A, B (168 residues) CATH domain: 3.40.50.1460
2fqu
Crystal structure of human caspase-1 (glu390->ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl- butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-vad- fmk)
Source: Homo sapiens. Human. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli.
Chains: A, B (170 residues) CATH domain: 3.40.50.1460
2fqv
Crystal structure of human caspase-1 (arg286->ala, glu390- >ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3- methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli.
Chains: A, B (163 residues) CATH domain: 3.40.50.1460
2h48
Crystal structure of human caspase-1 (cys362->ala, cys364->a cys397->ala) in complex with 3-[2-(2-benzyloxycarbonylamino butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-vad-f
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
2h4w
Crystal structure of human caspase-1 (glu390->asp) in comple [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propion 4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (168 residues) CATH domain: 3.40.50.1460
2h4y
Crystal structure of human caspase-1 (arg286->lys) in comple [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propion 4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (163 residues) CATH domain: 3.40.50.1460
2h51
Crystal structure of human caspase-1 (glu390->asp and arg286 complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyry propionylamino]-4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (167 residues) CATH domain: 3.40.50.1460
2h54
Crystal structure of human caspase-1 (thr388->ala) in comple [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propion 4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (170 residues) CATH domain: 3.40.50.1460
2hbq
Crystal structure of wildtype human caspase-1 in complex wit benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamin pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (168 residues) CATH domain: 3.40.50.1460
2hbr
Crystal structure of human caspase-1 (arg286->ala) in comple [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propion 4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (168 residues) CATH domain: 3.40.50.1460
2hby
Crystal structure of human caspase-1 (glu390->ala) in comple [2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propion 4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (170 residues) CATH domain: 3.40.50.1460
2hbz
Crystal structure of human caspase-1 (arg286->ala, glu390->a complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyry propionylamino]-4-oxo-pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (163 residues) CATH domain: 3.40.50.1460
3d6f
Crystal structure of human caspase-1 with a naturally-occurr arg240->gln substitution in complex with 3-[2-(2- benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamin pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
3d6h
Crystal structure of human caspase-1 with a naturally-occurr asn263->ser substitution in complex with 3-[2-(2- benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamin pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (166 residues) CATH domain: 3.40.50.1460
3d6m
Crystal structure of human caspase-1 with a naturally-occurr lys319->arg substitution in complex with 3-[2-(2- benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamin pentanoic acid (z-vad-fmk)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (173 residues) CATH domain: 3.40.50.1460
3e4c
Procaspase-1 zymogen domain crystal strucutre
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human RNA isolate. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (271 residues) CATH domain: 3.40.50.1460
3ns7
Succinic acid amides as p2-p3 replacements for inhibitors of interleukin-1beta converting enzyme (ice or caspase 1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: casp1, il1bc, il1bce. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (162 residues) CATH domain: 3.40.50.1460