_EC 3.4.21.93 Proprotein convertase 1. 3 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,536 PDB entries]
EC 3.4.21.93 Proprotein convertase 1. [3 PDB entries]    
1kn6

Reaction: Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
Other name(s): Nec 1. Neuroendocrine convertase 1. PC1. Prohormone convertase I.
Comments: A calcium dependent enzyme, maximally active at about pH 5.5. Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin. Unlike prohormone convertase 2, does not cleave proluteinizing- hormone-releasing hormone. Usually processing of prodynorphin occurs at a bond in which P2 is Thr. Present in the regulated secretory pathway of neuroendocrine cells, commonly actin co-operatively with prohormone convertase 2. Belongs to peptidase family S8.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 3 PDB entries in enzyme class E.C.3.4.21.93

  PDB code Protein
1kn6
Solution structure of the mouse prohormone convertase 1 pro- domain
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (73 residues) CATH domain: 3.30.70.850
2kdt
Pc1/3 dcsg sorting domain structure in dpc
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: pcsk1, att-1, nec-1, nec1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (43 residues)
2ke3
Pc1/3 dcsg sorting domain in chaps
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: pcsk1, att-1, nec-1, nec1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (43 residues)