_EC 3.4.21.75 Furin. 3 PDB entries  
EC 3.-.-.- Hydrolases. [22,314 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [7,253 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,634 PDB entries]
EC 3.4.21.75 Furin. [3 PDB entries]    
1p8j

Reaction: Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
Other name(s): Dibasic processing enzyme. Paired basic amino acid residue cleaving enzyme. Prohormone convertase.
Comments: Activated by calcium. Belongs to peptidase family S8.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 3 PDB entries in enzyme class E.C.3.4.21.75

  PDB code Protein
1p8j
Crystal structure of the proprotein convertase furin
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: furin or fur or pcsk3. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: ovary cells. Synthetic: yes. Other_details: the peptide (decanoyl-arg-val-lys-arg-
Chains: A, B, C, D, E, F, G, H (470 residues) CATH domains: 3.40.50.200 2.60.120.260
4omc
X-ray structure of human furin in complex with the competiti inhibitor meta-guanidinomethyl-phac-rvr-amba
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fur, furin, pace, pcsk3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: hek293s. Synthetic: yes
Chains: A, B, C, D, E, F (466 residues) CATH domains: 3.40.50.200 2.60.120.260
4omd
X-ray structure of human furin in complex with the competiti inhibitor phac-rvr-amba
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: furin, fur, pace, pcsk3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: hek293s. Synthetic: yes
Chains: A, B, C, D, E, F (466 residues) CATH domains: 3.40.50.200 2.60.120.260