_EC 3.4.21.7 Plasmin. 29 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,536 PDB entries]
EC 3.4.21.7 Plasmin. [29 PDB entries]    
1b2i

Reaction: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
Other name(s): Fibrinase. Fibrinolysin.
Comments: Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin. Belongs to peptidase family S1. Formerly Ec 3.4.4.14.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 29 PDB entries in enzyme class E.C.3.4.21.7

  PDB code Protein
1b2i
Kringle 2 domain of human plasminogen: nmr solution structure of trans-4-aminomethylcyclohexane-1-carboxylic acid (amcha) complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (83 residues) CATH domain: 2.40.20.10
1bml
Complex of the catalytic domain of human plasmin and strepto
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Streptococcus dysgalactiae subsp. Equi organism_taxid: 119602. Strain: subsp. Equisimilis
Chains: A, B (250 residues) CATH domains: 2.40.10.10 2.40.10.10
1bui
Structure of the ternary microplasmin-staphylokinase-micropl complex: a proteinase-cofactor-substrate complex in action
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Phage 42d. Organism_taxid: 10715
Chains: A, B (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1cea
The structure of the non-covalent complex of recombinant kringle 1 domain of human plasminogen with eaca (epsilon- aminocaproic acid)
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (80 residues) CATH domain: 2.40.20.10
1ceb
The structure of the non-covalent complex of recombinant kringle 1 domain of human plasminogen with amcha (trans-4- aminomethylcyclohexane-1-carboxylic acid)
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (80 residues) CATH domain: 2.40.20.10
1ddj
Crystal structure of human plasminogen catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1hpj
Solution nmr structure of the human plasminogen kringle 1 domain complexed with 6-aminohexanoic acid at ph 5.3, 310k, derived from randomly generated structures using simulated annealing, 12 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood plasma
Chain: A (79 residues) CATH domain: 2.40.20.10
1hpk
Solution nmr structure of the human plasminogen kringle 1 domain complexed with 6-aminohexanoic acid at ph 5.3, 310k, derived from randomly generated structures using simulated annealing, minimized average structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: blood plasma
Chain: A (79 residues) CATH domain: 2.40.20.10
1i5k
Structure and binding determinants of the recombinant kringl of human plasminogen to an internal peptide from a group a streptococcal surface protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: vek-30 was synthesized by automated solid ph peptide synthesis
Chains: A, B (79 residues) CATH domain: 2.40.20.10
1ki0
The x-ray structure of human angiostatin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (253 residues) CATH domains: 2.40.20.10 2.40.20.10 2.40.20.10
1krn
Structure of kringle 4 at 4c temperature and 1.67 angstroms resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood
Chain: A (79 residues) CATH domain: 2.40.20.10
1l4d
Crystal structure of microplasminogen-streptokinase alpha domain complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Streptococcus dysgalactiae subsp. Equisimilis. Organism_taxid: 119602. Strain: subsp. Equisimilis.
Chain: A (249 residues) CATH domains: 2.40.10.10 2.40.10.10
1l4z
X-ray crystal structure of the complex of microplasminogen with alpha domain of streptokinase in the presence cadmium ions
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Streptococcus dysgalactiae subsp. Equisimilis. Organism_taxid: 119602. Strain: subsp. Equisimilis.
Chain: A (248 residues) CATH domains: 2.40.10.10 2.40.10.10
1pk4
Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-angstroms resolution
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (79 residues) CATH domain: 2.40.20.10
1pkr
The structure of recombinant plasminogen kringle 1 and the fibrin binding site
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (80 residues) CATH domain: 2.40.20.10
1pmk
Kringle-kringle interactions in multimer kringle structures
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (78 residues) CATH domain: 2.40.20.10
1qrz
Catalytic domain of plasminogen
Source: Homo sapiens. Human. Organism_taxid: 9606.
Chains: A, B, C, D (246 residues) CATH domains: 2.40.10.10 2.40.10.10
1rjx
Human plasminogen catalytic domain, k698m mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood. Gene: plg. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: B (243 residues) CATH domains: 2.40.10.10 2.40.10.10
2doh
The x-ray crystallographic structure of the angiogenesis inh angiostatin, bound a to a peptide from the group a streptoc surface protein pam
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plg. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: vek-30 is an internal peptide within pam
Chain: X (165 residues) CATH domain: Unassigned
2doi
The x-ray crystallographic structure of the angiogenesis inh angiostatin, bound to a peptide from the group a streptococ protein pam
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plg. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: vek-30 is an internal peptide within the streptococcus protein pam
Chains: X, A (168 residues) CATH domain: Unassigned
2knf
Solution structure and functional characterization of human plasminogen kringle 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plg. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_variant: (met+)
Chain: A (86 residues) CATH domain: Unassigned
2l0s
Solution structure of human plasminogen kringle 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plg. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: expressed in 15n-labeled m9 minimal medium
Chain: A (83 residues) CATH domain: 2.40.20.10
2pk4
The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (80 residues) CATH domain: 2.40.20.10
3uir
Crystal structure of the plasmin-textilinin-1 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plg. Expressed in: escherichia coli. Expression_system_taxid: 562. Pseudonaja textilis textilis. Eastern brown snake. Organism_taxid: 169397.
Chains: A, B (243 residues) CATH domains: 2.40.10.10 2.40.10.10
4a5t
Structural basis for the conformational modulation
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: S (767 residues) CATH domains: 3.50.4.10 Unassigned Unassigned Unassigned Unassigned Unassigned 2.40.10.10 2.40.10.10
4dcb
Y. Pestis plasminogen activator pla in complex with human pl activation loop peptide alp11
Source: Yersinia pestis. Organism_taxid: 632. Gene: pla, yppcp1.07, yp_ppcp08. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606.
Chain: F (11 residues)
4dur
The x-ray crystal structure of full-length type ii human pla
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma
Chains: A, B (756 residues) CATH domains: 3.50.4.10 Unassigned Unassigned Unassigned Unassigned Unassigned 2.40.10.10 2.40.10.10
4duu
The x-ray crystal structure of full-length type i human plas
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: plasma
Chain: A (682 residues)
5hpg
Structure and ligand determinants of the recombinant kringle 5 domain of human plasminogen
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (84 residues) CATH domain: 2.40.20.10