_EC 3.4.21.66 Thermitase. 4 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,536 PDB entries]
EC 3.4.21.66 Thermitase. [4 PDB entries]    
1tec

Reaction: Hydrolysis of proteins, including collagen.
Other name(s): Thermophilic Streptomyces serine protease.
Comments: From Thermoactinomyces vulgaris containing a single Cys, near the active site His, and inhibited by p-mercuribenzoate. The N-terminal extension of the polypeptide chain relative to subtilisin contributes to calcium-binding and the high thermostability. The amino acid composition and properties of the thermostable enzyme from Streptomyces rectus var. proteolyticus are closely similar. Belongs to peptidase family S8. Formerly Ec 3.4.4.16.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.3.4.21.66

  PDB code Protein
1tec
Crystallographic refinement by incorporation of molecular dynamics. The thermostable serine protease thermitase complexed with eglin-c
Source: Thermoactinomyces vulgaris. Organism_taxid: 2026. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chain: E (279 residues) CATH domain: 3.40.50.200
1thm
Crystal structure of thermitase at 1.4 angstroms resolution
Source: Thermoactinomyces vulgaris. Organism_taxid: 2026
Chain: A (279 residues) CATH domain: 3.40.50.200
2tec
Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 angstroms resolution and comparison of two crystal forms that differ in calcium content
Source: Thermoactinomyces vulgaris. Organism_taxid: 2026. Hirudinaria manillensis. Organism_taxid: 6419. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: E (279 residues) CATH domain: 3.40.50.200
3tec
Calcium binding to thermitase. Crystallographic studies of thermitase at 0, 5 and 100 mm calcium
Source: Thermoactinomyces vulgaris. Organism_taxid: 2026. Hirudinaria manillensis. Organism_taxid: 6419. Expressed in: unidentified. Expression_system_taxid: 32644
Chain: E (279 residues) CATH domain: 3.40.50.200