_EC 3.4.21.59 Tryptase. 8 PDB entries  
EC 3.-.-.- Hydrolases. [8,019 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [2,602 PDB entries]
EC 3.4.21.- Serine endopeptidases. [916 PDB entries]
EC 3.4.21.59 Tryptase. [8 PDB entries]    
2f9n

Reaction: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
Other name(s): Lung tryptase. Mast cell protease Ii. Mast cell tryptase. Pituitary tryptase. Skin tryptase.
Comments: Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. Belongs to peptidase family S1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 8 PDB entries in enzyme class E.C.3.4.21.59

  PDB code Protein
2f9n
Crystal structure of the recombinant human alpha i tryptase k192q/d216g in complex with leupeptin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tps1, tps2, tpsab1, tpsb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: this is a microbial protease inhibitor
Chains: A, B, C, D (243 residues) CATH domains: 2.40.10.10 2.40.10.10
2f9p
Crystal structure of the recombinant human alpha i tryptase d216g in complex with leupeptin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tpsab1, tps1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes
Chains: A, B, C, D (243 residues) CATH domains: 2.40.10.10 2.40.10.10
2fpz
Human tryptase with 2-amino benzimidazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tpsb2, tps2. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B, C, D (243 residues) CATH domains: 2.40.10.10 2.40.10.10
2fs8
Human beta-tryptase ii with inhibitor cra-29382
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tpsb2, tps2. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B, D (243 residues) CATH domains: 2.40.10.10 2.40.10.10
2fww
Human beta-tryptase ii complexed with 4-piperidinebutyrate to make acylenzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tpsb2, tps2. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: B, C, D ( residues)
2fxr
Human beta tryptase ii complexed with activated ketone inhibitor cra-29382
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tpsb2, tps2. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B, C, D (243 residues) CATH domains: 2.40.10.10 2.40.10.10
2zeb
Potent, nonpeptide inhibitors of human mast cell tryptase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tpsb2
Chains: A, B, C, D (243 residues) CATH domains: 2.40.10.10 2.40.10.10
2zec
Potent, nonpeptide inhibitors of human mast cell tryptase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tpsb2
Chains: A, B, C, D (243 residues) CATH domains: 2.40.10.10 2.40.10.10