_EC 3.4.21.47 Alternative-complement-pathway C3/C5 convertase. 11 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,536 PDB entries]
EC 3.4.21.47 Alternative-complement-pathway C3/C5 convertase. [11 PDB entries]    
1dle

Reaction: Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha- chain to yield C5a and C5b.
Other name(s): C3 convertase. C3 proactivator. C5 convertase. Complement component C3/C5 convertase (alternative). Complement factor B. Properdin factor B.
Comments: A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. Bb is formed by cleavage of proenzyme factor B by factor d. Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. C3b,Bb is stabilized in plasma by factor P. Belongs to peptidase family S1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 11 PDB entries in enzyme class E.C.3.4.21.47

  PDB code Protein
1dle
Factor b serine protease domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood
Chains: A, B (288 residues) CATH domains: 2.40.10.10 2.40.10.10
1q0p
A domain of factor b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bf. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (192 residues) CATH domain: 3.40.50.410
1rrk
Crystal structure analysis of the bb segment of factor b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bf. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: bti-tn-5b1-4. Expression_system_cell: egg. Other_details: sf9 cells were also used
Chain: A (480 residues) CATH domains: 3.40.50.410 2.40.10.10 2.40.10.10
1rs0
Crystal structure analysis of the bb segment of factor b complexed with di-isopropyl-phosphate (dip)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bf. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: bti-tn-5b1-4. Expression_system_cell: egg. Other_details: sf9 cells were also used
Chain: A (480 residues) CATH domains: 3.40.50.410 2.40.10.10 2.40.10.10
1rtk
Crystal structure analysis of the bb segment of factor b complexed with 4-guanidinobenzoic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bf. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: bti-tn-5b1-4. Expression_system_cell: egg. Other_details: sf9 cells were also used
Chain: A (486 residues) CATH domains: 3.40.50.410 2.40.10.10 2.40.10.10
2ok5
Human complement factor b
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: human. Gene: cfb, bf. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Chain: A (710 residues) CATH domains: Unassigned Unassigned
2win
C3 convertase (c3bbb) stabilized by scin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_variant: gnti-. Expression_system_cell_line: hek293es. Staphylococcus aureus. Organism_taxid: 1280.
Chains: I, J, K, L (507 residues) CATH domains: 3.40.50.410 2.40.10.10 2.40.10.10
2xwb
Crystal structure of complement c3b in complex with factors
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Tissue: plasma. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293-es.
Chains: F, H (714 residues) CATH domains: Unassigned Unassigned 3.40.50.410
2xwj
Crystal structure of complement c3b in complex with factor b
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293-es.
Chains: I, J, K, L (712 residues) CATH domains: Unassigned Unassigned 3.40.50.410
3hrz
Cobra venom factor (cvf) in complex with human factor b
Source: Naja kaouthia. Organism_taxid: 8649. Other_details: cobra venom. Homo sapiens. Human. Organism_taxid: 9606. Gene: cfb, bf, bfd. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Chain: D (693 residues) CATH domains: Unassigned Unassigned
3hs0
Cobra venom factor (cvf) in complex with human factor b
Source: Naja kaouthia. Organism_taxid: 8649. Other_details: cobra venom. Homo sapiens. Human. Organism_taxid: 9606. Gene: cfb, bf, bfd. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Chains: D, I (699 residues) CATH domains: Unassigned Unassigned