_EC 3.4.21.37 Leukocyte elastase. 9 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,846 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,535 PDB entries]
EC 3.4.21.37 Leukocyte elastase. [9 PDB entries]    
1b0f

Reaction: Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
Other name(s): Bone marrow serine protease. Lysosomal elastase. Medullasin. Neutrophil elastase.
Comments: Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. Belongs to peptidase family S1. Formerly Ec 3.4.4.7 and Ec 3.4.21.11.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 9 PDB entries in enzyme class E.C.3.4.21.37

  PDB code Protein
1b0f
Crystal structure of human neutrophil elastase with mdl 101,
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: neutrophil
Chain: A (218 residues) CATH domains: 2.40.10.10 2.40.10.10
1h1b
Crystal structure of human neutrophil elastase complexed with an inhibitor (gw475151)
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: leukocyte
Chains: A, B (218 residues) CATH domains: 2.40.10.10 2.40.10.10
1hne
Structure of human neutrophil elastase in complex with a pep chloromethyl ketone inhibitor at 1.84-angstroms resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chain: E (218 residues) CATH domains: 2.40.10.10 2.40.10.10
1ppf
X-ray crystal structure of the complex of human leukocyte el (pmn elastase) and the third domain of the turkey ovomucoid
Source: Homo sapiens. Human. Organism_taxid: 9606. Meleagris gallopavo. Turkey. Organism_taxid: 9103
Chain: E (218 residues) CATH domains: 2.40.10.10 2.40.10.10
1ppg
The refined 2.3 angstroms crystal structure of human leukocy elastase in a complex with a valine chloromethyl ketone inh
Source: Homo sapiens. Human. Organism_taxid: 9606. Synthetic: yes
Chain: E (218 residues) CATH domains: 2.40.10.10 2.40.10.10
2rg3
Covalent complex structure of elastase
Source: Homo sapiens. Human. Gene: ela2. Expressed in: escherichia coli
Chain: A (218 residues) CATH domains: 2.40.10.10 2.40.10.10
2z7f
Crystal structure of the complex of human neutrophil elastas 1/2slpi
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: sputum. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: E (218 residues) CATH domains: 2.40.10.10 2.40.10.10
3q76
Structure of human neutrophil elastase (uncomplexed)
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (218 residues) CATH domains: 2.40.10.10 2.40.10.10
3q77
Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (218 residues) CATH domains: 2.40.10.10 2.40.10.10