_EC 3.4.21.22 Coagulation factor IXa. 20 PDB entries  
EC 3.-.-.- Hydrolases. [22,330 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [7,256 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,634 PDB entries]
EC 3.4.21.22 Coagulation factor IXa. [20 PDB entries]    
1cfh

Reaction: Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Other name(s): Christmas factor.
Comments: The proenzyme factor Ix is activated by ec 3.4.21.27. Belongs to peptidase family S1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 20 PDB entries in enzyme class E.C.3.4.21.22

  PDB code Protein
1cfh
Structure of the metal-free gamma-carboxyglutamic acid-rich membrane binding region of factor ix by two-dimensional nmr spectroscopy
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (47 residues) CATH domain: 4.10.740.10
1cfi
Nmr structure of calcium ion-bound gamma-carboxy-glutamic acid-rich domain of factor ix
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: blood
Chain: A (47 residues) CATH domain: 4.10.740.10
1edm
Epidermal growth factor-like domain from human factor ix
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: rz1032, xl1-blue, mc1061. Gene: human factor ix. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, C (39 residues)
1ixa
The three-dimensional structure of the first egf-like module of human factor ix: comparison with egf and tgf-a
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (39 residues)
1j34
Crystal structure of mg(ii)-and ca(ii)-bound gla domain of factor ix complexed with binding protein
Source: Trimeresurus flavoviridis. Organism_taxid: 88087. Secretion: venom. Bos taurus. Cattle. Organism_taxid: 9913. Secretion: plasma
Chain: C (46 residues) CATH domain: 4.10.740.10
1j35
Crystal structure of ca(ii)-bound gla domain of factor ix complexed with binding protein
Source: Trimeresurus flavoviridis. Organism_taxid: 88087. Secretion: venom. Bos taurus. Cattle. Organism_taxid: 9913. Secretion: plasma
Chain: C (46 residues) CATH domain: 4.10.740.10
1mgx
Coagulation factor, mg(ii), nmr, 7 structures (backbone atoms only)
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (47 residues) CATH domain: 4.10.740.10
1nl0
Crystal structure of human factor ix gla domain in complex of an inhibitory antibody, 10c12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: 10c12. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the protein was chemically synthesized. The sequence of the protein is naturally found in homo sapiens.
Chain: G (45 residues) CATH domain: 4.10.740.10
1pfx
Porcine factor ixa
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: blood. Gene: pete. Gene: pete
Chains: C, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1rfn
Human coagulation factor ixa in complex with p-amino benzamidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10
1x7a
Porcine factor ixa complexed to 1-{3-[amino(imino) methyl]phenyl}-n-[4-(1h-benzimidazol-1-yl)-2-fluorophenyl]- 3-(trifluoromethyl)-1h-pyrazole-5-carboxamide
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organism_taxid: 9823
Chains: C, L (235 residues) CATH domains: 2.40.10.10 2.40.10.10
2wph
Factor ixa superactive triple mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: E, S (59 residues) CATH domain: 2.10.25.10
2wpi
Factor ixa superactive double mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: E, S (59 residues) CATH domain: 2.10.25.10
2wpj
Factor ixa superactive triple mutant, nacl-soaked
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: E, S (59 residues) CATH domain: 2.10.25.10
2wpk
Factor ixa superactive triple mutant, ethylene glycol-soaked
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: E, S (59 residues) CATH domain: 2.10.25.10
2wpl
Factor ixa superactive triple mutant, edta-soaked
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: E, S (59 residues) CATH domain: 2.10.25.10
2wpm
Factor ixa superactive mutant, egr-cmk inhibited
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: E, S (59 residues) CATH domain: 2.10.25.10
3kcg
Crystal structure of the antithrombin-factor ixa- pentasaccharide complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f9. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: serpinc1, at3, pro0309. Expression_system_cell: bhk
Chains: L, H (54 residues) CATH domain: 2.10.25.10
3lc3
Benzothiophene inhibitors of factor ixa
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f9. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D (235 residues) CATH domains: 2.40.10.10 2.40.10.10
3lc5
Selective benzothiophine inhibitors of factor ixa
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f9. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (235 residues) CATH domains: 2.40.10.10 2.40.10.10