_EC 3.4.21.119 Kallikrein 13. 1 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,846 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,535 PDB entries]
EC 3.4.21.119 Kallikrein 13. [1 PDB entries]    
1ao5

Reaction: Hydrolyzes mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-|- pair in the N-terminus, to yield mature renin.
Other name(s): Epidermal growth factor-binding protein type B. MGK-13. Prece. PRECE-1. Prorenin converting enzyme 1. Prorenin-converting enzyme. Proteinase P.
Comments: Specific for prorenin from the mouse submandibular gland, as prorenin from the mouse kidney (Ren1) and human prorenin are not substrates. Site-directed mutagenesis studies have shown that the enzyme will also cleave prorenin when Lys-Arg is replaced by Arg-Arg or Gln-Arg but the rate of reaction is much slower when Lys-Lys is used. Also able to process pro-interleukin-1-beta (pro-IL-1-beta) in mouse submandibular gland to form IL-1-beta. Belongs to peptidase family S1A.
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There are 1 PDB entries in enzyme class E.C.3.4.21.119

  PDB code Protein
1ao5
Mouse glandular kallikrein-13 (prorenin converting enzyme)
Source: Mus musculus. House mouse. Organism_taxid: 10090. Strain: swiss webster. Organ: submandibular gland
Chains: A, B (236 residues) CATH domains: 2.40.10.10 2.40.10.10