_EC 3.4.21.117 Stratum corneum chymotryptic enzyme. 1 PDB entries  
EC 3.-.-.- Hydrolases. [8,019 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [2,602 PDB entries]
EC 3.4.21.- Serine endopeptidases. [916 PDB entries]
EC 3.4.21.117 Stratum corneum chymotryptic enzyme. [1 PDB entries]    
2qxj

Reaction: Cleavage of proteins with aromatic side chains in the P1 position.
Other name(s): Kallikrein 7. Scce. Serine protease 6.
Comments: This enzyme has wide substrate specificity, being able to degrade heat-denatured bovine casein and the alpha-chain of native human fibrinogen. It cleaves the B chain of bovine insulin at 6-Leu-|-Cya-7 (cysteic acid), 16-Tyr-|-Leu-17, 25-Phe-|-Tyr-26 and 26-Tyr-|-Thr-27. It is thought to play a role in the desquamation (skin-shedding) of the outer layer of skin, the stratum corneum, by degrading intercellular cohesive structures. Belongs to peptidase family S1A.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 1 PDB entries in enzyme class E.C.3.4.21.117

  PDB code Protein
2qxj
Crystal structure of human kallikrein 7 in complex with suc- ala-ala-pro-phe-chloromethylketone and copper
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: klk7, prss6, scce. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (224 residues) CATH domains: 2.40.10.10 2.40.10.10