_EC 3.4.21.110 C5a peptidase. 2 PDB entries  
EC 3.-.-.- Hydrolases. [19,580 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,506 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,457 PDB entries]
EC 3.4.21.110 C5a peptidase. [2 PDB entries]    
1xf1

Reaction: The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59.
Other name(s): Scp. Streptococcal C5a peptidase.
Comments: Surface-associated subtilisin-like serine peptidase with very specific substrate specificity. Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a. Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties. Belongs to peptidase family S8A.
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There are 2 PDB entries in enzyme class E.C.3.4.21.110

  PDB code Protein
1xf1
Structure of c5a peptidase- a key virulence factor from streptococcus
Source: Streptococcus pyogenes. Organism_taxid: 1314. Gene: scpa. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (926 residues) CATH domains: 3.40.50.200 3.50.30.30 2.60.40.1710 Unassigned 2.60.40.320
3eif
1.9 angstrom crystal structure of the active form of the c5a peptidase from streptococcus pyogenes (scpa)
Source: Streptococcus pyogenes. Organism_taxid: 1314. Strain: b220. Gene: scpa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (936 residues) CATH domains: 3.40.50.200 3.50.30.30 2.60.40.1710 Unassigned 2.60.40.320