_EC 3.4.21.106 Hepsin. 5 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,846 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,535 PDB entries]
EC 3.4.21.106 Hepsin. [5 PDB entries]    
1o5e

Reaction: Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys.
Comments: This type-II membrane-associated serine peptidase has been implicated in cell growth and development. The enzyme has been shown to activate blood coagulation factor Vii by cleavage of the 152-Arg-|-Ile-153 peptide bound in Bhk cells, thus indicating a possible role in the initiation of blood coagulation. There is no cleavage after aromatic or aliphatic residues. The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphatic residue. The nature of the residue at S3 also affects hydrolysis, with Gln
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There are 5 PDB entries in enzyme class E.C.3.4.21.106

  PDB code Protein
1o5e
Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hpn or tmprss1. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_variant: km71. Expression_system_variant: km71
Chains: L, H (110 residues) CATH domain: 3.10.250.10
1o5f
Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hpn or tmprss1. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Expression_system_variant: km71. Expression_system_variant: km71
Chains: L, H (110 residues) CATH domain: 3.10.250.10
1p57
Extracellular domain of human hepsin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (110 residues) CATH domain: 3.10.250.10
1z8g
Crystal structure of the extracellular region of the transme serine protease hepsin with covalently bound preferred subs
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hpn, tmprss1. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: A (366 residues) CATH domains: 3.10.250.10 2.40.10.10 2.40.10.10
3t2n
Human hepsin protease in complex with the fab fragment of an inhibitory antibody
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hpn, tmprss1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: freestyle 293 cells. Organism_taxid: 9606
Chains: A, B (339 residues) CATH domains: 3.10.250.10 2.40.10.10 2.40.10.10