_EC 3.4.21.104 Mannan-binding lectin-associated serine protease-2. 6 PDB entries  
EC 3.-.-.- Hydrolases. [21,057 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,846 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,535 PDB entries]
EC 3.4.21.104 Mannan-binding lectin-associated serine protease-2. [6 PDB entries]    
1nt0

Reaction: Selective cleavage after Arg-223 in complement component C2 (-Ser- Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).
Other name(s): Mannan-binding lectin-associated serine peptidase 2. Mannose-binding lectin-associated serine protease-2. MASP-2. MASP2. MBP-associated serine protease-2.
Comments: Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement. Displays C1s-like esterolytic activity (cf. Ec 3.4.21.42). It also cleaves C4 and C2 with efficiencies that are relatively higher than those of Ec 3.4.21.42. Belongs to peptidase family S1A.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 6 PDB entries in enzyme class E.C.3.4.21.104

  PDB code Protein
1nt0
Crystal structure of the cub1-egf-cub2 region of masp2
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_tissue: ovary cells
Chains: A, G (257 residues) CATH domains: 2.60.120.290 2.10.25.10 2.60.120.290
1q3x
Crystal structure of the catalytic region of human masp-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: masp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (321 residues) CATH domains: 2.10.70.10 2.40.10.10 2.40.10.10
1szb
Crystal structure of the human mbl-associated protein 19 (map19)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: masp2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (167 residues) CATH domains: 2.60.120.290 2.10.25.10
1zjk
Crystal structure of the zymogen catalytic region of human m
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: masp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (390 residues) CATH domains: 2.10.70.10 2.10.70.10 2.40.10.10 2.40.10.10
3tvj
Catalytic fragment of masp-2 in complex with its specific in developed by directed evolution on sgci scaffold
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: masp2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Schistocerca gregaria. Desert locust. Organism_taxid: 7010.
Chains: A, B (83 residues) CATH domain: 2.10.70.10
4fxg
Complement c4 in complex with masp-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: masp2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: G, H, I, J (145 residues) CATH domains: 2.10.70.10 2.10.70.10