_EC 3.4.21.103 Physarolisin. 0 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,536 PDB entries]
EC 3.4.21.103 Physarolisin. [-]    

Reaction: Milk clotting activity. Preferential cleavage of 8-Gly-|-Ser-9 in B chain of insulin most rapidly, followed by 11-Leu-|-Val-12, 19-Cys(SO(3)H)-|-Gly and 24-Phe-|-Phe-25. No action on Ac-Phe-Tyr(I)(2).
Other name(s): Dictyostelium discoideum aspartic proteinase. Dictyostelium discoideum aspartic proteinase E. Physaropepsin. Physarum aspartic proteinase. Physarum flavicomum aspartic proteinase. Physarum polycephalum acid proteinase.
Comments: From the slime mold Physarum polycephalum. Is not inhibited by pepstatin, but is blocked by methyl 2-diazoacetamidohexanoate. Closely similar enzymes are found in Dictyostelium discoideum and P.flavicomum. Belongs to peptidase family S53. Formerly Ec 3.4.4.17, Ec 3.4.23.6 and Ec 3.4.23.27.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are no PDB entries in enzyme class E.C.3.4.21.103