_EC 3.4.21.1 Chymotrypsin. 66 PDB entries  
EC 3.-.-.- Hydrolases. [22,196 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [7,241 PDB entries]
EC 3.4.21.- Serine endopeptidases. [2,631 PDB entries]
EC 3.4.21.1 Chymotrypsin. [66 PDB entries]    
1ab9

Reaction: Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.
Other name(s): Alpha-chymotrypsin. Chymotrypsin A. Chymotrypsin B.
Comments: Belongs to peptidase family S1. Formerly Ec 3.4.4.5 and Ec 3.4.4.6.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 66 PDB entries in enzyme class E.C.3.4.21.1

  PDB code Protein
1ab9
Crystal structure of bovine gamma-chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913.
Chains: B, C (131 residues) CATH domain: 2.40.10.10
1acb
Crystal and molecular structure of the bovine alpha-chymotry c complex at 2.0 angstroms resolution
Source: Bos taurus. Bovine. Organism_taxid: 9913. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421
Chain: E (241 residues) CATH domains: 2.40.10.10 2.40.10.10
1afq
Crystal structure of bovine gamma-chymotrypsin complexed wit synthetic inhibitor
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: B, C (131 residues) CATH domain: 2.40.10.10
1ca0
Bovine chymotrypsin complexed to appi
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreatic. Gene: a4. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human.
Chains: A, B, C, F, G, H (11 residues)
1cbw
Bovine chymotrypsin complexed to bpti
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chains: A, B, C, F, G, H (11 residues)
1cgi
Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (kazal-type)
Source: Bos taurus. Cattle. Organism_taxid: 9913. Homo sapiens. Human. Organism_taxid: 9606
Chain: E (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1cgj
Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (kazal-type)
Source: Bos taurus. Cattle. Organism_taxid: 9913. Homo sapiens. Human. Organism_taxid: 9606
Chain: E (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1chg
Chymotrypsinogen,2.5 angstroms crystal structure, comparison with alpha-chymotrypsin,and implications for zymogen activation
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (230 residues) CATH domains: 2.40.10.10 2.40.10.10
1cho
Crystal and molecular structures of the complex of alpha- Chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Meleagris gallopavo. Turkey. Organism_taxid: 9103
Chains: F, G (131 residues) CATH domain: 2.40.10.10
1dlk
Crystal structure analysis of delta-chymotrypsin bound to a chloromethyl ketone inhibitor
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Synthetic: yes. Other_details: this sequence was synthetically constructed
Chains: A, B, C, D (13 residues)
1eq9
Crystal structure of fire ant chymotrypsin complexed to pmsf
Source: Solenopsis invicta. Red fire ant. Organism_taxid: 13686
Chains: A, B (222 residues) CATH domains: 2.40.10.10 2.40.10.10
1ex3
Crystal structure of bovine chymotrypsinogen a (tetragonal)
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1gcd
Refined crystal structure of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (237 residues) CATH domains: 2.40.10.10 2.40.10.10
1gct
Is gamma-chymotrypsin a tetrapeptide acyl-enzyme adduct of g chymotrypsin?
Source: Bos taurus. Organism_taxid: 9913.
Chains: A, B, C (11 residues)
1gg6
Crystal stucture of gamma chymotrypsin with n-acetyl- phenylalanine trifluoromethyl ketone bound at the active site
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: B, C (131 residues) CATH domain: 2.40.10.10
1ggd
Crystal stucture of gamma chymotrypsin with n-acetyl-leucil- phenylalanine aldehyde bound at the active site
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: B, C (131 residues) CATH domain: 2.40.10.10
1gha
A second active site in chymotrypsin? the x-ray crystal stru n-acetyl-d-tryptophan bound to gamma-chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913.
Chains: E, F, G (11 residues)
1ghb
A second active site in chymotrypsin? the x-ray crystal stru n-acetyl-d-tryptophan bound to gamma-chymotrypsin
Source: Bos taurus. Organism_taxid: 9913.
Chains: E, F, G (11 residues)
1gl0
Structure of the complex between bovine alpha-chymotrypsin and pmp-d2v, an inhibitor from the insect locusta migratoria
Source: Synthetic: yes. Locusta migratoria. Migratory locust. Organism_taxid: 7004. Organ: brain, fat body. Tissue: hemolymph. Bos taurus. Bovine. Organism_taxid: 9913.
Chain: E (241 residues) CATH domains: 2.40.10.10 2.40.10.10
1gl1
Structure of the complex between bovine alpha-chymotrypsin and pmp-c, an inhibitor from the insect locusta migratoria
Source: Synthetic: yes. Locusta migratoria. Migratory locust. Organism_taxid: 7004. Organ: brain, fat body. Tissue: hemolymph. Bos taurus. Bovine. Organism_taxid: 9913.
Chains: A, B, C (239 residues) CATH domains: 2.40.10.10 2.40.10.10
1gmc
The x-ray crystal structure of the tetrahedral intermediate chymotrypsin in hexane
Source: Bos taurus. Cattle. Organism_taxid: 9913.
Chains: E, F, G (11 residues)
1gmd
X-ray crystal structure of gamma-chymotrypsin in hexane
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: E, F, G (11 residues)
1gmh
Refined crystal structure of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: F, G (131 residues) CATH domain: 2.40.10.10
1hja
Lys 18 variant of turkey ovomucoid inhibitor third domain complexed with alpha-chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Other_details: commercial product of worthington biochemical corporation. Expressed in: escherichia coli. Expression_system_taxid: 562. Meleagris gallopavo. Turkey.
Chains: B, C (131 residues) CATH domain: 2.40.10.10
1k2i
Crystal structure of gamma-chymotrypsin in complex with 7- hydroxycoumarin
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: 1 (236 residues) CATH domains: 2.40.10.10 2.40.10.10
1kdq
Crystal structure analysis of the mutant s189d rat chymotrypsin
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chains: A, B (130 residues) CATH domain: 2.40.10.10
1mtn
Bovine alpha-chymotrypsin:bpti crystallization
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: A, B, C, E, F, G (11 residues)
1n8o
Crystal structure of a complex between bovine chymotrypsin a
Source: Bos taurus. Cattle. Organism_taxid: 9913. Escherichia coli. Organism_taxid: 83333. Strain: k12
Chains: A, B, C (11 residues)
1oxg
Crystal structure of a complex formed between organic solvent treated bovine alpha-chymotrypsin and its autocatalytically produced highly potent 14-residue peptide at 2.2 resolution
Source: Bos taurus. Bovine. Organism_taxid: 9913. Secretion: pancreatic secretion. Secretion: pancreatic secretion
Chains: A, B (241 residues) CATH domains: 2.40.10.10 2.40.10.10
1p2m
Structural consequences of accommodation of four non- cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: t7 promoter
Chains: A, C (238 residues) CATH domains: 2.40.10.10 2.40.10.10
1p2n
Structural consequences of accommodation of four non- cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: t7 promoter
Chains: A, C (239 residues) CATH domains: 2.40.10.10 2.40.10.10
1p2o
Structural consequences of accommodation of four non- cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: t7 promoter
Chains: A, C (238 residues) CATH domains: 2.40.10.10 2.40.10.10
1p2q
Structural consequences of accommodation of four non- cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: t7 promoter
Chains: A, C (239 residues) CATH domains: 2.40.10.10 2.40.10.10
1t7c
Crystal structure of the p1 glu bpti mutant- bovine chymotrypsin complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (239 residues) CATH domains: 2.40.10.10 2.40.10.10
1t8l
Crystal structure of the p1 met bpti mutant- bovine chymotrypsin complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (239 residues) CATH domains: 2.40.10.10 2.40.10.10
1t8m
Crystal structure of the p1 his bpti mutant- bovine chymotrypsin complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (239 residues) CATH domains: 2.40.10.10 2.40.10.10
1t8n
Crystal structure of the p1 thr bpti mutant- bovine chymotrypsin complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (239 residues) CATH domains: 2.40.10.10 2.40.10.10
1t8o
Crystal structure of the p1 trp bpti mutant- bovine chymotrypsin complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (239 residues) CATH domains: 2.40.10.10 2.40.10.10
1vgc
Gamma-chymotrypsin l-para-chloro-1-acetamido boronic acid inhibitor complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: B, C (131 residues) CATH domain: 2.40.10.10
1yph
High resolution structure of bovine alpha-chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: C, E, B, D, F (131 residues) CATH domain: 2.40.10.10
2cga
Bovine chymotrypsinogen a. X-ray crystal structure analysis and refinement of a new crystal form at 1.8 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chains: A, B (245 residues) CATH domains: 2.40.10.10 2.40.10.10
2cha
The structure of crystalline alpha-chymotrypsin, v.The atom structure of tosyl-alpha-chymotrypsin at 2 angstroms resolu
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: B, C, F, G (131 residues) CATH domain: 2.40.10.10
2gch
Refined crystal structure of gamma-chymotrypsin at 1.9 angst resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: E, F, G (11 residues)
2gct
Structure of gamma-chymotrypsin in the range ph 2.0 to ph 10 suggests that gamma-chymotrypsin is a covalent acyl-enzyme low ph
Source: Bos taurus. Organism_taxid: 9913.
Chains: A, B, C (11 residues)
2gmt
Three-dimensional structure of chymotrypsin inactivated with acetyl-l-alanyl-l-phenylalanyl-chloroethyl ketone: implicat the mechanism of inactivation of serine proteases by chloro
Source: Bos taurus. Cattle. Organism_taxid: 9913.
Chains: B, C (131 residues) CATH domain: 2.40.10.10
2jet
Crystal structure of a trypsin-like mutant (s189d, a226g) chymotrypsin.
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Organ: pancreas. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (12 residues)
2p8o
Crystal structure of a benzohydroxamic acid/vanadate complex bound to chymotrypsin a
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: B, C (131 residues) CATH domain: 2.40.10.10
2vgc
Gamma-chymotrypsin d-para-chloro-1-acetamido boronic acid inhibitor complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: B, C (131 residues) CATH domain: 2.40.10.10
2y6t
Molecular recognition of chymotrypsin by the serine protease inhibitor ecotin from yersinia pestis
Source: Bos taurus. Cattle. Organism_taxid: 9913. Other_details: activated bovine chymotrypsin was purchased sigma-aldrich. Yersinia pseudotuberculosis. Organism_taxid: 502800. Strain: ypiii. Expressed in: escherichia coli.
Chains: A, B, C, D (240 residues) CATH domains: 2.40.10.10 2.40.10.10
3bg4
The crystal structure of guamerin in complex with chymotrypsin and the development of an elastase-specific inhibitor
Source: Bos taurus. Bovine. Organism_taxid: 9913. Hirudo nipponia. Leech. Organism_taxid: 42736. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B, C (11 residues)
3cp7
Crystal structure of a thermostable serine protease al20 from extremophilic microoganism
Source: Nesterenkonia abyssinica
Chains: A, B (216 residues) CATH domains: 2.40.10.10 2.40.10.10
3gch
Chemistry of caged enzymes. Binding of photoreversible cinna chymotrypsin
Source: Bos taurus. Bos taurus
Chains: A, B, C (11 residues)
3gct
Structure of gamma- Chymotrypsin in the range p H 2.0 to p suggests that gamma-chymotrypsin is a covalent acyl-enzyme low p H
Source: Bos taurus. Cattle. Organism_taxid: 9913.
Chains: E, F, G (11 residues)
3ru4
Crystal structure of the bowman-birk serine protease inhibit complex with trypsin and chymotrypsin
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Vigna unguiculata. Cowpea. Organism_taxid: 3917. Organism_taxid: 9913
Chains: C, D, E (11 residues)
3t62
Crystal structure of recombinant kunitz type serine protease inhibitor-1 from the caribbean sea anemone stichodactyla he in complex with bovine chymotrypsin
Source: Bos taurus. Bovine. Organism_taxid: 9913. Organ: pancreas. Stichodactyla helianthus. Caribbean sea anemone. Organism_taxid: 6123. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B, C (240 residues) CATH domains: 2.40.10.10 2.40.10.10
3vgc
Gamma-chymotrypsin l-naphthyl-1-acetamido boronic acid acid inhibitor complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: B, C (131 residues) CATH domain: 2.40.10.10
4cha
Structure of alpha- Chymotrypsin refined at 1.68 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: A, B, C, F, G (11 residues)
4gch
Structure and activity of two photoreversible cinnamates bou chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: E, F, G (11 residues)
4q2k
Bovine alpha chymotrypsin bound to a cyclic peptide inhibito
Source: Bos taurus. Bovine. Organism_taxid: 9913
Chains: A, B, C, D (231 residues) CATH domains: 2.40.10.10 2.40.10.10
4vgc
Gamma-chymotrypsin d-naphthyl-1-acetamido boronic acid inhibitor complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: B, C (131 residues) CATH domain: 2.40.10.10
5cha
The refinement and the structure of the dimer of alpha- Chymotrypsin at 1.67- Angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: B, C, F, G (131 residues) CATH domain: 2.40.10.10
5gch
Chemistry of caged enzymes II . Photoactivation of inhibite chymotrypsin
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: E, F, G (11 residues)
6cha
Structure of a tetrahedral transition state complex of alpha- Chymotrypsin at 1.8- Angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: B, C, F, G (131 residues) CATH domain: 2.40.10.10
6gch
Structure of chymotrypsin- Trifluoromethyl ketone inhibitor complexes. Comparison of slowly and rapidly equilibrating inhibitors
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: E, F, G (11 residues)
7gch
Structure of chymotrypsin- Trifluoromethyl ketone inhibitor comparison of slowly and rapidly equilibrating inhibitors
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: E, F, G (11 residues)
8gch
Gamma-chymotrypsin is a complex of alpha-chymotrypsin with i autolysis products
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organism_taxid: 9913
Chains: E, F, G (11 residues)