_EC 3.4.17.2 Carboxypeptidase B. 31 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.17.- Metallocarboxypeptidases. [165 PDB entries]
EC 3.4.17.2 Carboxypeptidase B. [31 PDB entries]    
1cpb

Reaction: Preferential release of a C-terminal lysine or arginine amino acid.
 


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Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Protaminase.
Cofactor(s): Zn(2+).
Comments: Isolated from cattle, pig and dogfish pancreas, and other sources, including skin fibroblasts and adrenal medulla. Belongs to peptidase family M14. Formerly Ec 3.4.2.2 and Ec 3.4.12.3.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 31 PDB entries in enzyme class E.C.3.4.17.2

  PDB code Protein
1cpb
Structure of carboxypeptidase b at 2.8 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: A, B (82 residues)
1kwm
Human procarboxypeptidase b: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (tafi)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (402 residues) CATH domains: 3.30.70.340 3.40.630.10
1nsa
Three-dimensional structure of porcine procarboxypeptidase b: a structural basis of its inactivity
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (395 residues) CATH domains: 3.30.70.340 3.40.630.10
1pba
The nmr structure of the activation domain isolated from porcine procarboxypeptidase b
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (81 residues) CATH domain: 3.30.70.340
1z5r
Crystal structure of activated porcine pancreatic carboxypeptidase b
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
1zg7
Crystal structure of 2-(5-{[amino(imino)methyl]amino}-2- chlorophenyl)-3-sulfanylpropanoic acid bound to activated porcine pancreatic carboxypeptidase b
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (305 residues) CATH domain: 3.40.630.10
1zg8
Crystal structure of (r)-2-(3-{[amino(imino) methyl]amino}phenyl)-3-sulfanylpropanoic acid bound to activated porcine pancreatic carboxypeptidase b
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (305 residues) CATH domain: 3.40.630.10
1zg9
Crystal structure of 5-{[amino(imino)methyl]amino}-2- (sulfanylmethyl)pentanoic acid bound to activated porcine pancreatic carboxypeptidase b
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (305 residues) CATH domain: 3.40.630.10
1zli
Crystal structure of the tick carboxypeptidase inhibitor in complex with human carboxypeptidase b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Rhipicephalus bursa. Organism_taxid: 67831. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (306 residues) CATH domain: 3.40.630.10
2c1c
Structural basis of the resistance of an insect carboxypeptidase to plant protease inhibitors
Source: Helicoverpa zea. Corn earworm. Organism_taxid: 7113. Tissue: epithelium. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (312 residues) CATH domain: 3.40.630.10
2jew
Crystal structure of ( (2s)-5-amino-2-((1-n-propyl-1h- imidazol-4-yl)methyl)pentanoic acid) uk396,082 a tafia inhibitor, bound to activated porcine pancreatic carboxypeptidaseb
Source: Sus scrofa. Pig. Organism_taxid: 9823. Tissue: pancreatic. Other_details: purchased
Chain: A (304 residues) CATH domain: 3.40.630.10
2piy
Crystal structure of activated porcine pancreatic carboxypeptidase b (s)-2-(3-aminomethyl-phenyl)-3-{hydroxy- [(r)-2-methyl-1-(3-phenyl-propane-1-sulfonylamino)-propyl]- phosphinoyl}-propionic acid {zk 528} complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2piz
Crystal structure of activated porcine pancreatic carboxypeptidase b 2-(3-guanidino-phenyl)-3-[hydroxy-(3- phenyl-propyl)-phosphinoyl]-propionic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (305 residues) CATH domain: 3.40.630.10
2pj0
Crystal structure of activated porcine pancreatic carboxypeptidase b [((r)-1-benzyloxycarbonylamino-2-methyl- propyl)-hydroxy-phosphinoyloxy]-(3-guanidino-phenyl)- acetic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pj1
Crystal structure of activated porcine pancreatic carboxypeptidase b (3-aminomethyl-phenyl)-[((r)-1- benzyloxycarbonylamino-2-methyl-propyl)-hydroxy- phosphinoyloxy]-acetic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pj2
Crystal structure of activated porcine pancreatic carboxypeptidase b 2-(3-aminomethyl-phenyl)-3-[((r)-1- benzyloxycarbonylamino-2-methyl-propyl)-hydroxy- phosphinoyl]-propionic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pj3
Crystal structure of activated porcine pancreatic carboxypeptidase b (3-guanidino-phenyl)-{hydroxy-[(r)-2- methyl-1-(3-phenyl-propionylamino)-propyl]-phosphinoyloxy}- acetic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pj4
Crystal structure of activated porcine pancreatic carboxypeptidase b [((r)-benzyloxycarbonylamino-cyclohexyl- methyl)-hydroxy-phosphinoyloxy]-(3-guanidino-phenyl)- acetic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B (304 residues) CATH domain: 3.40.630.10
2pj5
Crystal structure of activated porcine pancreatic carboxypeptidase b [((r)-1-benzyloxycarbonylamino-hexyl)- hydroxy-phosphinoyloxy]-(3-guanidino-phenyl)-acetic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pj6
Crystal structure of activated porcine pancreatic carboxypeptidase b 2-(3-aminomethyl-phenyl)-3-{hydroxy- [(r)-2-methyl-1-(2-phenyl-ethanesulfonylamino)-propyl]- phosphinoyl}-propionic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (304 residues) CATH domain: 3.40.630.10
2pj7
Crystal structure of activated porcine pancreatic carboxypeptidase b 2-(3-aminomethyl-phenyl)-3-[((r)-1- benzenesulfonylamino-2-methyl-propyl)-hydroxy-phosphinoyl]- propionic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pj8
Crystal structure of activated porcine pancreatic carboxypeptidase b 2-(3-aminomethyl-phenyl)-3-{[(r)-1- (biphenyl-4-sulfonylamino)-2-methyl-propyl]-hydroxy- phosphinoyl}-propionic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pj9
Crystal structure of activated porcine pancreatic carboxypeptidase b 2-(3-aminomethyl-phenyl)-3-{[(r)-1- (benzo[1,2,5]thiadiazole-4-sulfonylamino)-2-methyl-propyl]- hydroxy-phosphinoyl}-propionic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (304 residues) CATH domain: 3.40.630.10
2pja
Crystal structure of activated porcine pancreatic carboxypeptidase b 3-{[(r)-1-((s)-2-benzyloxycarbonylamino- 3-phenyl-propionylamino)-2-methyl-propyl]-hydroxy- phosphinoyl}-2-(3-guanidino-phenyl)-propionic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pjb
Crystal structure of activated porcine pancreatic carboxypeptidase b 2-(3-aminomethyl-phenyl)-3-{[1-((s)-2- benzyloxycarbonylamino-3-phenyl-propane-1-sulfonylamino)-2- methyl-propyl]-hydroxy-phosphinoyl}-propionic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
2pjc
Crystal structure of activated porcine pancreatic carboxypeptidase b ({(r)-1-[(s)-2-benzyloxycarbonylamino-3- (4-hydroxy-phenyl)-propionylamino]-2-methyl-propyl}- hydroxy-phosphinoyloxy)-(3-guanidino-phenyl)-acetic acid complex
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chains: A, B, C (304 residues) CATH domain: 3.40.630.10
3glj
A polymorph of carboxypeptidase b zymogen structure
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: cpb1, cpb. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (395 residues) CATH domains: 3.30.70.340 3.40.630.10
3wab
Carboxypeptidase b in complex with dd2
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (304 residues) CATH domain: 3.40.630.10
3wc5
Carboxypeptidase b in complex with dd9
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (304 residues) CATH domain: 3.40.630.10
3wc6
Carboxypeptidase b in complex with 2nd zinc
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (304 residues) CATH domain: 3.40.630.10
3wc7
Carboxypeptidase b in complex with ef6265
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (304 residues) CATH domain: 3.40.630.10