_EC 3.4.17.1 Carboxypeptidase A. 36 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,852 PDB entries]
EC 3.4.17.- Metallocarboxypeptidases. [165 PDB entries]
EC 3.4.17.1 Carboxypeptidase A. [36 PDB entries]    
1arl

Reaction: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
 


+
=

+

Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Carboxypolypeptidase.
Cofactor(s): Zn(2+).
Comments: Isolated from cattle, pig and dogfish pancreas, and other sources including mast cells and skeletal muscle. Belongs to peptidase family M14. Formerly Ec 3.4.2.1 and Ec 3.4.12.2.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 36 PDB entries in enzyme class E.C.3.4.17.1

  PDB code Protein
1arl
Carboxypeptidase a with zn removed
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
1arm
Carboxypeptidase a with zn replaced by hg
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
Bound ligand:   Het Group TRS is 40.00% similar to enzyme product L-amino acid
1bav
Carboxypeptidase a complexed with 2-benzyl-3-iodo-propanoic acid (bip)
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chains: A, B, C, D (307 residues) CATH domain: 3.40.630.10
1cbx
Crystal structure of the complex between carboxypeptidase a and the biproduct analog inhibitor l-benzylsuccinate at 2.0 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (307 residues) CATH domain: 3.40.630.10
1cps
Structural comparison of sulfodiimine and sulfonamide inhibitors in their complexes with zinc enzymes
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (307 residues) CATH domain: 3.40.630.10
1cpx
Beta form of carboxypeptidase a (residues 3-307) from bovine pancreas in an orthorhombic crystal form with two zinc ions in the active site.
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Other_details: sigma #c0261. Cox et al. (1964) biochemistry 3, 44-47
Chain: A (305 residues) CATH domain: 3.40.630.10
1ee3
Cadmium-substituted bovine pancreatic carboxypeptidase a (alfa-form) at ph 7.5 and 2 mm chloride in monoclinic crystal form
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: P (305 residues) CATH domain: 3.40.630.10
1ell
Cadmium-substituted bovine pancreatic carboxypeptidase a (alfa-form) at ph 7.5 and 0.25 m chloride in monoclinic crystal form.
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: P (305 residues) CATH domain: 3.40.630.10
1elm
Cadmium-substituted bovine pacreatic carboxypeptidase a (alfa-form) at ph 5.5 and 2 mm chloride in monoclinic crystal form.
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: P (305 residues) CATH domain: 3.40.630.10
1f57
Carboxypeptidase a complex with d-cysteine at 1.75 a
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (307 residues) CATH domain: 3.40.630.10
Bound ligand:   Het Group DCY is 62.00% similar to enzyme product L-amino acid
1hdq
Crystal structure of bovine pancreatic carboxypeptidase a complexed with d-n-hydroxyaminocarbonyl phenylalanine at 2.3 a
Source: Bos bovis. Bovine. Organism_taxid: 9913. Organ: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
1hdu
Crystal structure of bovine pancreatic carboxypeptidase a complexed with aminocarbonylphenylalanine at 1.75 a
Source: Bos bovis. Bovine. Organism_taxid: 9913. Organ: pancreas
Chains: A, B, D, E (307 residues) CATH domain: 3.40.630.10
1hee
Crystal structure of bovine pancreatic carboxypeptidase a complexed with l-n-hydroxyaminocarbonyl phenylalanine at 2.3 a
Source: Bos bovis. Bovine. Organism_taxid: 9913. Organ: pancreas
Chains: A, B, D, E (307 residues) CATH domain: 3.40.630.10
1iy7
Crystal structure of cpa and sulfamide-based inhibitor complex
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (307 residues) CATH domain: 3.40.630.10
1jqg
Crystal structure of the carboxypeptidase a from helicoverpa armigera
Source: Helicoverpa armigera. Cotton bollworm. Organism_taxid: 29058. Tissue: midgut. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (409 residues) CATH domains: 3.30.70.340 3.40.630.10
1m4l
Structure of native carboxypeptidase a at 1.25 resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
1pca
Three dimensional structure of porcine pancreatic procarboxypeptidase a. A comparison of the a and b zymogens and their determinants for inhibition and activation
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (402 residues) CATH domains: 3.30.70.340 3.40.630.10
Bound ligand:   Het Group VAL is 55.00% similar to enzyme product L-amino acid
1pyt
Ternary complex of procarboxypeptidase a, proproteinase e, and chymotrypsinogen c
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Organ: pancreas
Chains: A, B (94 residues) CATH domain: 3.30.70.340
1yme
Structure of carboxypeptidase
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
1zlh
Crystal structure of the tick carboxypeptidase inhibitor in complex with bovine carboxypeptidase a
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Rhipicephalus bursa. Organism_taxid: 67831. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (301 residues) CATH domain: 3.40.630.10
2abz
Crystal structure of c19a/c43a mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase a
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Hirudo medicinalis. Medicinal leech. Organism_taxid: 6421. Expressed in: escherichia coli bl21(de3).
Chains: A, B (299 residues) CATH domain: 3.40.630.10
2ctb
The high resolution crystal structure of the complex between carboxypeptidase a and l-phenyl lactate
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (307 residues) CATH domain: 3.40.630.10
2ctc
The high resolution crystal structure of the complex between carboxypeptidase a and l-phenyl lactate
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
2rfh
Crystal structure analysis of cpa-2-benzyl-3-nitropropanoic acid complex
Source: Bos taurus. Bovine. Organ: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
2v77
Crystal structure of human carboxypeptidase a1
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: pancreas. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (308 residues) CATH domain: 3.40.630.10
3cpa
X-ray crystallographic investigation of substrate binding to carboxypeptidase a at subzero temperature
Source: Bos taurus. Bovine. Organism_taxid: 9913. Tissue: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
Bound ligand:   Het Group GLY is 66.00% similar to enzyme product L-amino acid
3fju
Ascaris suum carboxypeptidase inhibitor in complex with huma carboxypeptidase a1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cpa1, cpa. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Ascaris suum. Pig roundworm. Organism_taxid: 6253.
Chain: A (307 residues) CATH domain: 3.40.630.10
Bound ligand:   Het Group ACT is 66.00% similar to enzyme product L-amino acid
3fvl
Crystallogic studies on the complex of carboxypeptidase a with inhibitors using alpha-hydroxy ketone as zinc-binding group
Source: Bos taurus. Bovine. Organism_taxid: 9913. Tissue: pancreas
Chains: A, C, E (307 residues) CATH domain: 3.40.630.10
3fx6
X-ray crystallographic studies on the complex of carboxypeptidase a with the inhibitor using alpha-nitro ketone as the zinc-binding group
Source: Bos taurus. Bovine. Organism_taxid: 9913. Tissue: bovine pancreas
Chains: A, C, E (307 residues) CATH domain: 3.40.630.10
3i1u
Carboxypeptidase a inhibited by a thiirane mechanism-based i
Source: Bos taurus. Bovine. Organism_taxid: 9913. Tissue: pancreas
Chain: A (303 residues) CATH domain: 3.40.630.10
3kgq
Carboxypeptidase a liganded to an organic small-molecule: conformational changes
Source: Bos taurus. Bovine. Organism_taxid: 9913. Tissue: pancreas
Chain: A (303 residues) CATH domain: 3.40.630.10
Bound ligand:   Het Group ACN is 42.00% similar to enzyme product L-amino acid
4cpa
Refined crystal structure of the potato inhibitor complex of carboxypeptidase a at 2.5 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Solanum tuberosum. Potato. Organism_taxid: 4113
Chains: A, B (307 residues) CATH domain: 3.40.630.10
Bound ligand:   Het Group GLY is 83.00% similar to enzyme product L-amino acid
5cpa
Refined crystal structure of carboxypeptidase a at 1.54 angstroms resolution.
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (307 residues) CATH domain: 3.40.630.10
6cpa
Crystal structure of the complex of carboxypeptidase a with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (307 residues) CATH domain: 3.40.630.10
7cpa
Comparison of the structures of three carboxypeptidase a- phosphonate complexes determined by x-ray crystallography
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (307 residues) CATH domain: 3.40.630.10
8cpa
Comparison of the structures of three carboxypeptidase a- phosphonate complexes determined by x-ray crystallography
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (307 residues) CATH domain: 3.40.630.10