_EC 3.4.11.18 Methionyl aminopeptidase. 48 PDB entries  
EC 3.-.-.- Hydrolases. [8,019 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [2,602 PDB entries]
EC 3.4.11.- Aminopeptidases. [131 PDB entries]
EC 3.4.11.18 Methionyl aminopeptidase. [48 PDB entries]    
1b6a

Reaction: Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
Other name(s): Methionine aminopeptidase. Peptidase M.
Cofactor(s): Cobalt cation.
Comments: Removes the amino-terminal methionine from nascent proteins. Membrane-bound enzyme present in both prokaryotes and eukaryotes. Belongs to peptidase family M24A.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 48 PDB entries in enzyme class E.C.3.4.11.18

  PDB code Protein
1b6a
Human methionine aminopeptidase 2 complexed with tnp-470
Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Expressed in: spodoptera frugiperda mnpv. Expression_system_taxid: 10455. Expression_system_cell_line: sf21.
Chain: A (355 residues) CATH domains: 3.90.230.10 1.10.10.10
1c22
E. Coli methionine aminopeptidase: trifluoromethionine complex
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (262 residues) CATH domain: 3.90.230.10
1c23
E. Coli methionine aminopeptidase: methionine phosphonate complex
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (262 residues) CATH domain: 3.90.230.10
1c24
E. Coli methionine aminopeptidase: methionine phosphinate complex
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (262 residues) CATH domain: 3.90.230.10
1o0x
Crystal structure of methionine aminopeptidase (tm1478) from thermotoga maritima at 1.90 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm1478. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (249 residues) CATH domain: 3.90.230.10
1qxz
Crystal structure of s. Aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119
Source: Staphylococcus aureus. Organism_taxid: 1280. Strain: aureus mu50. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (249 residues) CATH domain: 3.90.230.10
1r5g
Crystal structure of metap2 complexed with a311263
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (369 residues) CATH domains: 3.90.230.10 1.10.10.10
1xgm
Methionine aminopeptidase from hyperthermophile pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261
Chains: A, B (295 residues) CATH domains: 3.90.230.10 1.10.10.10
1xgo
Methionine aminopeptidase from hyperthermophile pyrococcus furiosus
Source: Pyrococcus furiosus. Organism_taxid: 2261
Chain: A (295 residues) CATH domains: 3.90.230.10 1.10.10.10
1y1n
Identification of sh3 motif in m. Tuberculosis methionine aminopeptidase suggests a mode of interaction with the ribosome
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: map, mapb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: n-terminal his-tag was kept during crystallization but is not visible in the elecron density maps
Chain: A (282 residues) CATH domain: 3.90.230.10
1yj3
Crystal structure analysis of product bound methionine aminopeptidase type 1c from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: map, mapb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (282 residues) CATH domain: 3.90.230.10
1yw7
H-metap2 complexed with a444148
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: metap2, mnpep, p67eif2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 3.90.230.10 1.10.10.10
1yw8
H-metap2 complexed with a751277
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: metap2, mnpep, p67eif2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (369 residues) CATH domains: 3.90.230.10 1.10.10.10
2b3k
Crystal structure of human methionine aminopeptidase type i holo form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: metap1, kiaa0094. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (304 residues) CATH domain: 3.90.230.10
2dfi
Crystal structure of pf-map(1-292)-c
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: map. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (301 residues) CATH domains: 3.90.230.10 1.10.10.10
2ea2
H-metap2 complexed with a773812
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (369 residues) CATH domains: 3.90.230.10 1.10.10.10
2ea4
H-metap2 complexed with a797859
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (369 residues) CATH domains: 3.90.230.10 1.10.10.10
2evc
Crystal structure of e. Coli. Methionine amino peptidase in complex with 5-(2-(trifluoromethyl)phenyl)furan-2- carboxylic acid
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (259 residues) CATH domain: 3.90.230.10
2evm
Crystal structure of methionine aminopeptidase in complex with 5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (259 residues) CATH domain: 3.90.230.10
2evo
Crystal structure of methionine amino peptidase in complex with n-cyclopentyl-n-(thiazol-2-yl)oxalamide
Source: Escherichia coli. Organism_taxid: 562. Gene: map. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (260 residues) CATH domain: 3.90.230.10
2gg5
Novel bacterial methionine aminopeptidase inhibitors
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: map. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (263 residues) CATH domain: 3.90.230.10
2gg9
Novel bacterial methionine aminopeptidase inhibitors
Source: Escherichia coli k12. Organism_taxid: 83333. Strain: k-12. Gene: map. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (263 residues) CATH domain: 3.90.230.10
2gu6
E. Coli methionine aminopeptidase in complex with nlep, 1: 2, di-metalated
Source: Escherichia coli. Organism_taxid: 562. Gene: map. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (261 residues) CATH domain: 3.90.230.10
2gz5
Human type 1 methionine aminopeptidase in complex with ovali ang
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: metap1, kiaa0094. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (304 residues) CATH domain: 3.90.230.10
2nq6
Crystal structure of human methionine aminopeptidase type 1 with 3-tert-butoxycarbonylaminopyridine-2-carboxylic acid t ylamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: metap1, kiaa0094. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (304 residues) CATH domain: 3.90.230.10
2nq7
Crystal structure of type 1 human methionine aminopeptidase with 3-(2,2-dimethylpropionylamino)pyridine-2-carboxylic ac thiazole-2-ylamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: metap1, kiaa0094. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (304 residues) CATH domain: 3.90.230.10
2nw5
Structure of an encephalitozoon cuniculi methionine aminopeptidase type 2
Source: Encephalitozoon cuniculi gb-m1. Organism_taxid: 284813. Strain: gb-m1. Gene: map2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (356 residues) CATH domains: 3.90.230.10 1.10.10.10
2p99
E. Coli methionine aminopeptidase monometalated with inhibitor ye6
Source: Escherichia coli. Organism_taxid: 562. Gene: map. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (261 residues) CATH domain: 3.90.230.10
2q95
E. Coli methionine aminopeptidase mn-form with inhibitor a05
Source: Escherichia coli. Organism_taxid: 562. Gene: map. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (263 residues) CATH domain: 3.90.230.10
3cmk
Crystal structure of an encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor fumagillin bound
Source: Encephalitozoon cuniculi gb-m1. Organism_taxid: 284813. Strain: gb-m1. Gene: map2, ecu10_0750. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (356 residues) CATH domains: 3.90.230.10 1.10.10.10
3d0d
Crystal structure of an encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor tnp470 bound
Source: Encephalitozoon cuniculi gb-m1. Organism_taxid: 284813. Strain: gb-m1. Gene: map2, ecu10_0750. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (356 residues) CATH domains: 3.90.230.10 1.10.10.10
3d27
E. Coli methionine aminopeptidase with fe inhibitor w29
Source: Escherichia coli. Organism_taxid: 83333. Gene: map, b0168, jw0163. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (261 residues) CATH domain: 3.90.230.10
3fm3
Crystal structure of an encephalitozoon cuniculi methionine aminopeptidase type 2
Source: Encephalitozoon cuniculi. Organism_taxid: 6035. Strain: gb-m1. Gene: ecu10_0750, map2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (356 residues) CATH domains: 3.90.230.10 1.10.10.10
3fmq
Crystal structure of an encephalitozoon cuniculi methionine aminopeptidase type 2 with angiogenesis inhibitor fumagillin bound
Source: Encephalitozoon cuniculi. Organism_taxid: 6035. Strain: gb-m1. Gene: ecu10_0750, map2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: B ( residues)
3iu8
M. Tuberculosis methionine aminopeptidase with ni inhibitor t03
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: map, mapb, mt2929, mtv003.07c, rv2861c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (284 residues) CATH domain: 3.90.230.10
3iu9
M. Tuberculosis methionine aminopeptidase with ni inhibitor t07
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: map, mapb, mt2929, mtv003.07c, rv2861c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (284 residues) CATH domain: 3.90.230.10
3mat
E.Coli methionine aminopeptidase transition-state inhibitor
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21(de3). Synthetic: yes
Chain: A (264 residues) CATH domain: 3.90.230.10
3mr1
Crystal structure of methionine aminopeptidase from ricketts prowazekii
Source: Rickettsia prowazekii. Organism_taxid: 782. Gene: map, q9zcd3, rp824. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (249 residues) CATH domain: 3.90.230.10
3pka
M. Tuberculosis metap with bengamide analog y02, in mn form
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: map, mapb, mt2929, mtv003.07c, rv2861c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (284 residues) CATH domain: 3.90.230.10
3pkc
M. Tuberculosis metap with bengamide analog y08, in mn form
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: map, mapb, mt2929, mtv003.07c, rv2861c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (281 residues) CATH domain: 3.90.230.10
4flk
Human metap1 with bengamide analog y10, in mn form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa0094, map1, metap1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (304 residues) CATH domain: 3.90.230.10
4fo7
Pseudomonas aeruginosa metap, in mn form
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: pao1. Gene: map, pa3657. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (258 residues) CATH domain: 3.90.230.10
4fuk
Aminopeptidase from trypanosoma brucei
Source: Trypanosoma brucei brucei. Organism_taxid: 999953. Strain: 927/4 gutat10.1. Gene: tb10.61.1210, tb11.1240. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (329 residues) CATH domain: 3.90.230.10
4idy
Mycobacterium tuberculosis methionine aminopeptidase type 1c complex with 2-hydroxyethyl disulfide
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: map. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (282 residues) CATH domain: 3.90.230.10
4if7
Mycobacterium tuberculosis methionine aminopeptidase type 1c complex with homocysteine-methyl disulfide
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: map. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (282 residues) CATH domain: 3.90.230.10
4iks
Crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with n1-(5-chloro-6-methyl (pyridin-2-yl)pyrimidin-4-yl)-n2-(6-(trifluoromethyl)pyridi ethane-1,2-diamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: metap1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (304 residues) CATH domain: 3.90.230.10
4iu6
Human methionine aminopeptidase in complex with fz1: pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: metap1, kiaa0094. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (304 residues) CATH domain: 3.90.230.10
4juq
Pseudomonas aeruginosa metap t2n mutant, in mn form
Source: Pseudomonas aeruginosa. Organism_taxid: 208964. Strain: pao1. Gene: map, pa3657. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (258 residues) CATH domain: 3.90.230.10