_EC 3.2.1.46 Galactosylceramidase. 5 PDB entries  
EC 3.-.-.- Hydrolases. [20,839 PDB entries]
EC 3.2.-.- Glycosylases. [4,000 PDB entries]
EC 3.2.1.- Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compound [3,482 PDB entries]
EC 3.2.1.46 Galactosylceramidase. [5 PDB entries]    
3zr5

Reaction: D-galactosyl-N-acylsphingosine + H(2)O = D-galactose + N-acylsphingosine.
 


D-galactosyl-N-acylsphingosine
+ H(2)O
=
D-galactose
+
N-acylsphingosine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Galactocerebrosidase. Galactocerebroside beta-galactosidase. Galactosylceramide beta-galactosidase. Galcerase.
Comments: Cf. Ec 3.2.1.62.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 5 PDB entries in enzyme class E.C.3.2.1.46

  PDB code Protein
3zr5
Structure of galactocerebrosidase from mouse
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293 cells.
Chain: A (641 residues) CATH domains: 2.60.40.1180 3.20.20.80 2.60.120.560
Bound ligand:   Het Group NAG is 62.50% similar to enzyme product D-galactose
3zr6
Structure of galactocerebrosidase from mouse in complex with galactose
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293 cells.
Chain: A (641 residues) CATH domains: 2.60.40.1180 3.20.20.80 2.60.120.560
Bound ligands:   Het Group GAL corresponds to enzyme product D-galactose
  Het Group NAG is 40.74% similar to enzyme product N-acylsphingosine
4ccc
Structure of mouse galactocerebrosidase with 4nbdg: enzyme-substrate complex
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
Chain: A (640 residues) CATH domains: Unassigned 3.20.20.70 2.60.120.560
Bound ligands:   Het Group 147 is 57.14% similar to enzyme product D-galactose
  Het Group NAG is 40.74% similar to enzyme product N-acylsphingosine
4ccd
Structure of mouse galactocerebrosidase with d-galactal: enzyme-intermediate complex
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
Chain: A (640 residues) CATH domains: Unassigned 3.20.20.70 2.60.120.560
Bound ligands:   Het Group 2DG is 83.33% similar to enzyme product D-galactose
  Het Group NAG is 40.74% similar to enzyme product N-acylsphingosine
4cce
Structure of mouse galactocerebrosidase with galactose: enzyme-product complex
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293t.
Chain: A (640 residues) CATH domains: Unassigned 3.20.20.70 2.60.120.560
Bound ligands:   Het Group GAL corresponds to enzyme product D-galactose
  Het Group NAG is 40.74% similar to enzyme product N-acylsphingosine