_EC 3.2.1.3 Glucan 1,4-alpha-glucosidase. 36 PDB entries  
EC 3.-.-.- Hydrolases. [20,861 PDB entries]
EC 3.2.-.- Glycosylases. [4,007 PDB entries]
EC 3.2.1.- Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compound [3,484 PDB entries]
EC 3.2.1.3 Glucan 1,4-alpha-glucosidase. [36 PDB entries]    
1ac0

Reaction: Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D- glucose.
Other name(s): 4-alpha-D-glucan glucohydrolase. Amyloglucosidase. Exo-1,4-alpha-glucosidase. Gamma-amylase. Glucoamylase. Lysosomal alpha-glucosidase.
Comments: Most forms of the enzyme can rapidly hydrolyze 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyze 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides. This entry covers all such enzymes acting on polysaccharides more rapidly than on oligosaccharides. Ec 3.2.1.20 from mammalian intestine can catalyze similar reactions.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 36 PDB entries in enzyme class E.C.3.2.1.3

  PDB code Protein
1ac0
Glucoamylase, granular starch-binding domain complex with cyclodextrin, nmr, minimized average structure
Source: Aspergillus niger. Organism_taxid: 5061. Strain: ab4.1. Expressed in: aspergillus niger. Expression_system_taxid: 5061.
Chain: A (108 residues) CATH domain: 2.60.40.10
1acz
Glucoamylase, granular starch-binding domain complex with cyclodextrin, nmr, 5 structures
Source: Aspergillus niger. Organism_taxid: 5061. Strain: ab4.1. Expressed in: aspergillus niger. Expression_system_taxid: 5061.
Chain: A (108 residues) CATH domain: 2.60.40.10
1agm
Refined structure for the complex of acarbose with glucoamyl aspergillus awamori var. X100 to 2.4 angstroms resolution
Source: Aspergillus awamori. Organism_taxid: 105351
Chain: A (470 residues) CATH domain: 1.50.10.10
1ayx
Crystal structure of glucoamylase from saccharomycopsis fibuligera at 1.7 angstroms
Source: Saccharomycopsis fibuligera. Organism_taxid: 4944. Gene: glu1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (492 residues) CATH domain: 1.50.10.10
1dog
Refined structure for the complex of 1-deoxynojirimycin with glucoamylase from (aspergillus awamori) var. X100 to 2.4 an resolution
Source: Aspergillus awamori. Organism_taxid: 105351
Chain: A (470 residues) CATH domain: 1.50.10.10
1gah
Glucoamylase-471 complexed with acarbose
Source: Aspergillus awamori. Organism_taxid: 105351. Variant: x100
Chain: A (471 residues) CATH domain: 1.50.10.10
1gai
Glucoamylase-471 complexed with d-gluco-dihydroacarbose
Source: Aspergillus awamori. Organism_taxid: 105351. Variant: x100
Chain: A (472 residues) CATH domain: 1.50.10.10
1glm
Refined crystal structures of glucoamylase from aspergillus var. X100
Source: Aspergillus awamori. Organism_taxid: 105351
Chain: A (470 residues) CATH domain: 1.50.10.10
1kul
Glucoamylase, granular starch-binding domain, nmr, 5 structures
Source: Aspergillus niger. Organism_taxid: 5061. Strain: ab4.1. Gene: a. Niger glaa. Expressed in: aspergillus niger. Expression_system_taxid: 5061.
Chain: A (108 residues) CATH domain: 2.60.40.10
1kum
Glucoamylase, granular starch-binding domain, nmr, minimized average structure
Source: Aspergillus niger. Organism_taxid: 5061. Strain: ab4.1. Gene: a. Niger glaa. Expressed in: aspergillus niger. Expression_system_taxid: 5061.
Chain: A (108 residues) CATH domain: 2.60.40.10
1lf6
Crystal structure of bacterial glucoamylase
Source: Thermoanaerobacterium thermosaccharolyticum. Organism_taxid: 1517. Strain: dsm 571
Chains: A, B (674 residues) CATH domains: 2.70.98.10 1.50.10.10
1lf9
Crystal structure of bacterial glucoamylase complexed with a
Source: Thermoanaerobacterium thermosaccharoly organism_taxid: 1517. Strain: dsm 571
Chains: A, B (674 residues) CATH domains: 2.70.98.10 1.50.10.10
2d73
Crystal structure analysis of susb
Source: Bacteroides thetaiotaomicron vpi-5482. Organism_taxid: 226186. Strain: resseta (de3). Gene: susb. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (717 residues) CATH domains: 2.70.98.10 3.20.20.70 2.60.40.1180
2djm
Solution structure of n-terminal starch-binding domain of glucoamylase from rhizopus oryzae
Source: Rhizopus oryzae. Organism_taxid: 64495. Gene: amya. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (106 residues) CATH domain: Unassigned
2f6d
Structure of the complex of a glucoamylase from saccharomyco fibuligera with acarbose
Source: Saccharomycopsis fibuligera. Organism_taxid: 4944. Strain: hut 7212. Gene: glu1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (492 residues) CATH domain: 1.50.10.10
2fba
Glucoamylase from saccharomycopsis fibuligera at atomic resolution
Source: Saccharomycopsis fibuligera. Organism_taxid: 4944. Strain: hut7212. Gene: glu1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (492 residues) CATH domain: 1.50.10.10
2jka
Native structure of a family 97 alpha-glucosidase from bacteroides thetaiotaomicron
Source: Bacteroides thetaiotaomicron. Organism_taxid: 226186. Strain: vpi-5482. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (688 residues) CATH domain: 2.70.98.10
2jke
Structure of a family 97 alpha-glucosidase from bacteroides thetaiotaomicron in complex with deoxynojirimycin
Source: Bacteroides thetaiotaomicron. Organism_taxid: 226186. Strain: vpi-5482. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (687 residues) CATH domain: 2.70.98.10
2jkp
Structure of a family 97 alpha-glucosidase from bacteroides thetaiotaomicron in complex with castanospermine
Source: Bacteroides thetaiotaomicron. Organism_taxid: 226186. Strain: vpi-5482. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (687 residues) CATH domain: 2.70.98.10
2qly
Crystral structure of the n-terminal subunit of human maltas glucoamylase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mgam, mga, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (863 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
2qmj
Crystral structure of the n-terminal subunit of human maltas glucoamylase in complex with acarbose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mgam, mga, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (863 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
2vn4
Glycoside hydrolase family 15 glucoamylase from hypocrea jecorina
Source: Hypocrea jecorina. Organism_taxid: 51453
Chain: A (599 residues) CATH domains: 1.50.10.10 2.60.40.10
2vn7
Glycoside hydrolase family 15 glucoamylase from hypocrea jecorina
Source: Hypocrea jecorina. Organism_taxid: 51453
Chain: A (599 residues) CATH domains: 1.50.10.10 2.60.40.10
2zq0
Crystal structure of susb complexed with acarbose
Source: Bacteroides thetaiotaomicron. Organism_taxid: 818. Strain: vpi-5482. Gene: susb, bt_3703. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (704 residues) CATH domain: 2.70.98.10
3ctt
Crystal complex of n-terminal human maltase-glucoamylase wit casuarine
Source: Homo sapiens. Human. Gene: mgam, mga, mgaml. Expressed in: drosophila melanogaster.
Chain: A (862 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3eqa
Catalytic domain of glucoamylase from aspergillus niger comp tris and glycerol
Source: Aspergillus niger. Organism_taxid: 5061. Other_details: gene glaa
Chain: A (458 residues) CATH domain: 1.50.10.10
3gly
Refined crystal structures of glucoamylase from aspergillus var. X100
Source: Aspergillus awamori. Organism_taxid: 105351
Chain: A (470 residues) CATH domain: 1.50.10.10
3l4t
Crystal complex of n-terminal human maltase-glucoamylase with bj2661
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mga, mgam, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (856 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3l4u
Crystal complex of n-terminal human maltase-glucoamylase with de-o-sulfonated kotalanol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mga, mgam, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (864 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3l4v
Crystal complex of n-terminal human maltase-glucoamylase with kotalanol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mga, mgam, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (863 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3l4w
Crystal complex of n-terminal human maltase-glucoamylase with miglitol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mga, mgam, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (863 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3l4x
Crystal complex of n-terminal human maltase-glucoamylase with nr4-8
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mga, mgam, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (863 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3l4y
Crystal complex of n-terminal human maltase-glucoamylase with nr4-8ii
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mga, mgam, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (863 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3l4z
Crystal complex of n-terminal human maltase-glucoamylase with salacinol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mga, mgam, mgaml. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227.
Chain: A (863 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3ton
Crystral structure of thE C-terminal subunit of human maltas glucoamylase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mgam. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B (890 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180
3top
Crystral structure of thE C-terminal subunit of human maltas glucoamylase in complex with acarbose
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mgam. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chains: A, B (890 residues) CATH domains: 4.10.110.10 2.60.40.1760 3.20.20.80 2.60.40.1180 2.60.40.1180