_EC 3.2.1.28 Alpha,alpha-trehalase. 4 PDB entries  
EC 3.-.-.- Hydrolases. [21,094 PDB entries]
EC 3.2.-.- Glycosylases. [4,109 PDB entries]
EC 3.2.1.- Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compound [3,585 PDB entries]
EC 3.2.1.28 Alpha,alpha-trehalase. [4 PDB entries]    
2jf4

Reaction: Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose.
 


Alpha,alpha-trehalose
+ H(2)O
=
beta-D-glucose
+
alpha-D-glucose
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Trehalase.
Comments: The enzyme is an anomer-inverting glucosidase that catalyzes the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha- trehalose, releasing initially equimolar amounts of alpha- and beta- D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.3.2.1.28

  PDB code Protein
2jf4
Family 37 trehalase from escherichia coli in complex with validoxylamine
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (500 residues) CATH domain: 1.50.10.10
Bound ligand:   Het Group VDM is 40.00% similar to enzyme product D-glucose
2jg0
Family 37 trehalase from escherichia coli in complex with 1- thiatrehazolin
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (507 residues) CATH domain: 1.50.10.10
Bound ligand:   Het Group TTZ is 42.00% similar to enzyme product D-glucose
2jjb
Family 37 trehalase from escherichia coli in complex with casuarine-6-o-alpha-glucopyranose
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (504 residues) CATH domain: 1.50.10.10
Bound ligand:   Het Group GLC corresponds to enzyme product D-glucose
2wyn
Structure of family 37 trehalase from escherichia coli in complex with a casuarine-6-o-a-d-glucoside analogue
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (506 residues) CATH domain: 1.50.10.10
Bound ligand:   Het Group GLC corresponds to enzyme product D-glucose