_EC 3.2.1.22 Alpha-galactosidase. 37 PDB entries  
EC 3.-.-.- Hydrolases. [21,094 PDB entries]
EC 3.2.-.- Glycosylases. [4,109 PDB entries]
EC 3.2.1.- Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compound [3,585 PDB entries]
EC 3.2.1.22 Alpha-galactosidase. [37 PDB entries]    
1r46

Reaction: Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha- D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.
 



+
=

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Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Melibiase.
Cofactor(s): Mg(2+); NAD(+).
 
Mg(2+)

NAD(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also hydrolyzes alpha-D-fucosides.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 37 PDB entries in enzyme class E.C.3.2.1.22

  PDB code Protein
1r46
Structure of human alpha-galactosidase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: homo sapiens. Expression_system_taxid: 9606
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
1r47
Structure of human alpha-galactosidase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: homo sapiens. Expression_system_taxid: 9606
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
1szn
The structure of alpha-galactosidase
Source: Hypocrea jecorina. Organism_taxid: 51453
Chain: A (417 residues) CATH domains: 3.20.20.70 2.60.40.1180
1t0o
The structure of alpha-galactosidase from trichoderma reesei with beta-d-galactose
Source: Hypocrea jecorina. Organism_taxid: 51453
Chain: A (417 residues) CATH domains: 3.20.20.70 2.60.40.1180
1uas
Crystal structure of rice alpha-galactosidase
Source: Oryza sativa. Rice. Organism_taxid: 4530. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (362 residues) CATH domains: 3.20.20.70 2.60.40.1180
1zy9
Crystal structure of alpha-galactosidase (ec 3.2.1.22) (meli (tm1192) from thermotoga maritima at 2.34 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm1192. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (526 residues) CATH domains: Unassigned 3.20.20.70
2xn0
Structure of alpha-galactosidase from lactobacillus acidophi ncfm, ptcl4 derivative
Source: Lactobacillus acidophilus ncfm. Organism_taxid: 272621. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (729 residues) CATH domains: 2.70.98.60 3.20.20.70 2.60.40.1180
2xn1
Structure of alpha-galactosidase from lactobacillus acidophi with tris
Source: Lactobacillus acidophilus ncfm. Organism_taxid: 272621. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (729 residues) CATH domains: 2.70.98.60 3.20.20.70 2.60.40.1180
2xn2
Structure of alpha-galactosidase from lactobacillus acidophi with galactose
Source: Lactobacillus acidophilus ncfm. Organism_taxid: 272621. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (729 residues) CATH domains: 2.70.98.60 3.20.20.70 2.60.40.1180
2yfn
Galactosidase domain of alpha-galactosidase-sucrose kinase, agask
Source: Ruminococcus gnavus e1. Organism_taxid: 935582. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (719 residues) CATH domains: 2.70.98.60 3.20.20.70 2.60.40.1180
2yfo
Galactosidase domain of alpha-galactosidase-sucrose kinase, agask, in complex with galactose
Source: Ruminococcus gnavus e1. Organism_taxid: 935582. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (719 residues) CATH domains: 2.70.98.60 3.20.20.70 2.60.40.1180
3a21
Crystal structure of streptomyces avermitilis beta-l- arabinopyranosidase
Source: Streptomyces avermitilis. Organism_taxid: 33903. Strain: nbrc14893. Gene: agaa2, sav2186, sav_2186. Expressed in: streptomyces lividans. Expression_system_taxid: 1916.
Chains: A, B (614 residues) CATH domains: 3.20.20.70 2.60.40.1180 Unassigned 2.80.10.50
3a22
Crystal structure of beta-l-arabinopyranosidase complexed wi arabinose
Source: Streptomyces avermitilis. Organism_taxid: 33903. Strain: nbrc14893. Gene: agaa2, sav2186, sav_2186. Expressed in: streptomyces lividans. Expression_system_taxid: 1916.
Chains: A, B (614 residues) CATH domains: 3.20.20.70 2.60.40.1180 Unassigned 2.80.10.50
3a23
Crystal structure of beta-l-arabinopyranosidase complexed wi galactose
Source: Streptomyces avermitilis. Organism_taxid: 33903. Strain: nbrc14893. Gene: agaa2, sav2186, sav_2186. Expressed in: streptomyces lividans. Expression_system_taxid: 1916.
Chains: A, B (614 residues) CATH domains: 3.20.20.70 2.60.40.1180 Unassigned 2.80.10.50
3a24
Crystal structure of bt1871 retaining glycosidase
Source: Bacteroides thetaiotaomicron. Organism_taxid: 818. Strain: atcc 29148. Gene: bt_1871, vpi-5482. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (641 residues) CATH domains: 2.70.98.10 3.20.20.70 2.60.40.1180
3a5v
Crystal structure of alpha-galactosidase i from mortierella
Source: Umbelopsis vinacea. Organism_taxid: 44442. Other_details: synonym: mortierella vinacea
Chain: A (397 residues) CATH domains: 3.20.20.70 2.60.40.1180
3cc1
Crystal structure of a putative alpha-n-acetylgalactosaminid (bh1870) from bacillus halodurans c-125 at 2.00 a resolutio
Source: Bacillus halodurans c-125. Organism_taxid: 272558. Strain: c-125 / dsm 18197 / ferm 7344 / jcm 9153. Atcc: baa-125. Gene: np_242736.1, bh1870. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (433 residues) CATH domains: 3.20.20.70 2.60.40.1180
3gxn
Crystal structure of apo alpha-galactosidase a at ph 4.5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3gxp
Crystal structure of acid-alpha-galactosidase a complexed wi galactose at ph 4.5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3gxt
Crystal structure of alpha-galactosidase a at ph 4.5 complex deoxygalactonijirimycin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3hg2
Human alpha-galactosidase catalytic mechanism 1. Empty activ
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: homo sapiens. Expression_system_taxid: 9606
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3hg3
Human alpha-galactosidase catalytic mechanism 2. Substrate b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (395 residues) CATH domains: 3.20.20.70 2.60.40.1180
3hg4
Human alpha-galactosidase catalytic mechanism 3. Covalent in
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: homo sapiens. Expression_system_taxid: 9606
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3hg5
Human alpha-galactosidase catalytic mechanism 4. Product bou
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: homo sapiens. Expression_system_taxid: 9606
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lrk
Structure of alfa-galactosidase (mel1) from saccharomyces ce
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: mel1. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chain: A (452 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lrl
Structure of alfa-galactosidase (mel1) from saccharomyces ce with melibiose
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: mel1. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chain: A (452 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lrm
Structure of alfa-galactosidase from saccharomyces cerevisia raffinose
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: mel1. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chains: A, B, C, D (452 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lx9
Interconversion of human lysosomal enzyme specificities
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (391 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lxa
Interconversion of human lysosomal enzyme specificities
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (395 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lxb
Interconversion of human lysosomal enzyme specificities
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (395 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lxc
Interconversion of human lysosomal enzyme specificities
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (391 residues) CATH domains: 3.20.20.70 2.60.40.1180
3s5y
Pharmacological chaperoning in human alpha-galactosidase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: nicotiana benthamiana. Expression_system_taxid: 4100
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3s5z
Pharmacological chaperoning in human alpha-galactosidase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: nicotiana benthamiana. Expression_system_taxid: 4100.
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3tv8
Pharmacological chaperoning in human alpha-galactosidase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
4nxs
Crystal structure of human alpha-galactosidase a in complex deoxygalactonojirimycin-pfpht
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
4nzj
Crystal structure of a putative alpha-galactosidase (bf1418) bacteroides fragilis nctc 9343 at 1.57 a resolution
Source: Bacteroides fragilis. Organism_taxid: 272559. Strain: nctc 9343. Gene: bf9343_1347, yp_211072.1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (468 residues) CATH domains: 2.60.40.10 3.20.20.70 2.60.40.1180
4ogz
Crystal structure of a putative alpha-galactosidase/melibias from bacteroides fragilis nctc 9343 at 2.00 a resolution
Source: Bacteroides fragilis. Organism_taxid: 272559. Strain: nctc 9343. Gene: bf9343_4081, yp_213754.1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (461 residues) CATH domains: 2.60.40.10 3.20.20.70 2.60.40.1180