_EC 3.2.1.22 Alpha-galactosidase. 13 PDB entries  
EC 3.-.-.- Hydrolases. [8,019 PDB entries]
EC 3.2.-.- Glycosylases. [1,646 PDB entries]
EC 3.2.1.- Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compound [1,455 PDB entries]
EC 3.2.1.22 Alpha-galactosidase. [13 PDB entries]    
1t0o

Reaction: Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha- D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.
 



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Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Melibiase.
Cofactor(s): Mg(2+); NAD(+).
 
Mg(2+)

NAD(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.
Comments: Also hydrolyzes alpha-D-fucosides.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 13 PDB entries in enzyme class E.C.3.2.1.22

  PDB code Protein
1t0o
The structure of alpha-galactosidase from trichoderma reesei with beta-d-galactose
Source: Hypocrea jecorina. Organism_taxid: 51453
Chain: A (417 residues) CATH domains: 3.20.20.70 2.60.40.1180
1zy9
Crystal structure of alpha-galactosidase (ec 3.2.1.22) (meli (tm1192) from thermotoga maritima at 2.34 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: tm1192. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (526 residues) CATH domains: Unassigned 3.20.20.70
2yfn
Galactosidase domain of alpha-galactosidase-sucrose kinase, agask
Source: Ruminococcus gnavus e1. Organism_taxid: 935582. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (719 residues) CATH domains: 2.70.98.60 3.20.20.70 2.60.40.1180
2yfo
Galactosidase domain of alpha-galactosidase-sucrose kinase, agask, in complex with galactose
Source: Ruminococcus gnavus e1. Organism_taxid: 935582. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (719 residues) CATH domains: 2.70.98.60 3.20.20.70 2.60.40.1180
3a21
Crystal structure of streptomyces avermitilis beta-l- arabinopyranosidase
Source: Streptomyces avermitilis. Organism_taxid: 33903. Strain: nbrc14893. Gene: agaa2, sav2186, sav_2186. Expressed in: streptomyces lividans. Expression_system_taxid: 1916.
Chains: A, B (614 residues) CATH domains: 3.20.20.70 2.60.40.1180 Unassigned 2.80.10.50
3a23
Crystal structure of beta-l-arabinopyranosidase complexed wi galactose
Source: Streptomyces avermitilis. Organism_taxid: 33903. Strain: nbrc14893. Gene: agaa2, sav2186, sav_2186. Expressed in: streptomyces lividans. Expression_system_taxid: 1916.
Chains: A, B (614 residues) CATH domains: 3.20.20.70 2.60.40.1180 Unassigned 2.80.10.50
3a5v
Crystal structure of alpha-galactosidase i from mortierella
Source: Umbelopsis vinacea. Organism_taxid: 44442. Other_details: synonym: mortierella vinacea
Chain: A (397 residues) CATH domains: 3.20.20.70 2.60.40.1180
3gxt
Crystal structure of alpha-galactosidase a at ph 4.5 complex deoxygalactonijirimycin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3hg3
Human alpha-galactosidase catalytic mechanism 2. Substrate b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (395 residues) CATH domains: 3.20.20.70 2.60.40.1180
3hg4
Human alpha-galactosidase catalytic mechanism 3. Covalent in
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: homo sapiens. Expression_system_taxid: 9606
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3hg5
Human alpha-galactosidase catalytic mechanism 4. Product bou
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: homo sapiens. Expression_system_taxid: 9606
Chains: A, B (390 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lrm
Structure of alfa-galactosidase from saccharomyces cerevisia raffinose
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Gene: mel1. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.
Chains: A, B, C, D (452 residues) CATH domains: 3.20.20.70 2.60.40.1180
3lxc
Interconversion of human lysosomal enzyme specificities
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (391 residues) CATH domains: 3.20.20.70 2.60.40.1180