_EC 3.2.1.105 3-alpha-(S)-strictosidine beta-glucosidase. 4 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.2.-.- Glycosylases. [4,101 PDB entries]
EC 3.2.1.- Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compound [3,577 PDB entries]
EC 3.2.1.105 3-alpha-(S)-strictosidine beta-glucosidase. [4 PDB entries]    
2jf6

Pathway: Geissoschizine and Sarpagine Biosynthesis
Reaction: Strictosidine + H(2)O = D-glucose + strictosidine aglycone.
 


Strictosidine
+ H(2)O
=
D-glucose
+
strictosidine aglycone
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Strictosidine beta-glucosidase.
Comments: Does not act on a number of closely related glycosides. Strictosidine is a precursor of indole alkaloids.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 4 PDB entries in enzyme class E.C.3.2.1.105

  PDB code Protein
2jf6
Structure of inactive mutant of strictosidine glucosidase in complex with strictosidine
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (464 residues) CATH domain: 3.20.20.80
Bound ligand:   Het Group S55 corresponds to enzyme reactant Strictosidine
2jf7
Structure of strictosidine glucosidase
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (468 residues) CATH domain: 3.20.20.80
3zj7
Crystal structure of strictosidine glucosidase in complex with inhibitor-1
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli m15. Expression_system_taxid: 1007065.
Chains: A, B (467 residues) CATH domain: 3.20.20.80
Bound ligand:   Het Group C1K is 52.63% similar to enzyme product D-glucose
3zj8
Crystal structure of strictosidine glucosidase in complex wi inhibitor-2
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli m15. Expression_system_taxid: 1007065.
Chains: A, B (468 residues) CATH domain: 3.20.20.80
Bound ligand:   Het Group LR1 is 47.62% similar to enzyme product D-glucose