_EC 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase. 77 PDB entries  
EC 3.-.-.- Hydrolases. [21,317 PDB entries]
EC 3.1.-.- Acting on ester bonds. [6,034 PDB entries]
EC 3.1.4.- Phosphoric diester hydrolases. [466 PDB entries]
EC 3.1.4.53 3',5'-cyclic-AMP phosphodiesterase. [77 PDB entries]    
1e9k

Reaction: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
 


Adenosine 3',5'-cyclic phosphate
+ H(2)O
=
adenosine 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): cAMP-specific Pde. cAMP-specific phosphodiesterase.
Comments: Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. Ec 3.1.4.17 and Ec 3.1.4.35). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. Formerly Ec 3.1.4.n1.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 77 PDB entries in enzyme class E.C.3.1.4.53

  PDB code Protein
1e9k
The structure of the rack1 interaction sites located within the unique n-terminal region of the camp-specific phosphodiesterase, pde4d5.
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Chain: A (38 residues)
1f0j
Catalytic domain of human phosphodiesterase 4b2b
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: monocyte. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_cell_line: trichoplusia ni
Chains: A, B (351 residues) CATH domain: 1.10.1300.10
1loi
N-terminal splice region of rat c-amp phosphodiesterase, nmr, 7 structures
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain
Chain: A (26 residues)
1mkd
Crystal structure of pde4d catalytic domain and zardaverine complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (328 residues) CATH domain: 1.10.1300.10
1oyn
Crystal structure of pde4d2 in complex with (r,s)-rolipram
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (334 residues) CATH domain: 1.10.1300.10
1ptw
The crystal structure of amp-bound pde4 suggests a mechanism for phosphodiesterase catalysis
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (334 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group AMP is 54.00% similar to enzyme product nucleoside 5'-phosphate
1q9m
Three dimensional structures of pde4d in complex with roliprams and implication on inhibitor selectivity
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (334 residues) CATH domain: 1.10.1300.10
1ro6
Crystal structure of pde4b2b complexed with rolipram (r & s)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B (344 residues) CATH domain: 1.10.1300.10
1ro9
Crystal structures of the catalytic domain of phosphodiester complexed with 8-br-amp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B (338 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group 8BR is 52.00% similar to enzyme product nucleoside
1ror
Crystal structures of the catalytic domain of phosphodiester complexed with amp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B (338 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group AMP is 54.17% similar to enzyme product nucleoside
1tb5
Catalytic domain of human phosphodiesterase 4b in complex wi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group AMP is 54.17% similar to enzyme product nucleoside
1tb7
Catalytic domain of human phosphodiesterase 4d in complex wi
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (321 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group AMP is 54.17% similar to enzyme product nucleoside
1tbb
Catalytic domain of human phosphodiesterase 4d in complex wi rolipram
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (321 residues) CATH domain: 1.10.1300.10
1xlx
Catalytic domain of human phosphodiesterase 4b in complex wi cilomilast
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domain: 1.10.1300.10
1xlz
Catalytic domain of human phosphodiesterase 4b in complex wi filaminast
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domain: 1.10.1300.10
1xm4
Catalytic domain of human phosphodiesterase 4b in complex wi piclamilast
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domain: 1.10.1300.10
1xm6
Catalytic domain of human phosphodiesterase 4b in complex wi mesopram
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (338 residues) CATH domain: 1.10.1300.10
1xmu
Catalytic domain of human phosphodiesterase 4b in complex wi roflumilast
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (331 residues) CATH domain: 1.10.1300.10
1xmy
Catalytic domain of human phosphodiesterase 4b in complex wi rolipram
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domain: 1.10.1300.10
1xn0
Catalytic domain of human phosphodiesterase 4b in complex wi rolipram
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domain: 1.10.1300.10
1xom
Catalytic domain of human phosphodiesterase 4d in complex with cilomilast
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
1xon
Catalytic domain of human phosphodiesterase 4d in complex wi piclamilast
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (322 residues) CATH domain: 1.10.1300.10
1xoq
Catalytic domain of human phosphodiesterase 4d in complex wi roflumilast
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
1xor
Catalytic domain of human phosphodiesterase 4d in complex wi zardaverine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (321 residues) CATH domain: 1.10.1300.10
1xos
Catalytic domain of human phosphodiesterase 4b in complex wi sildenafil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (322 residues) CATH domain: 1.10.1300.10
1xot
Catalytic domain of human phosphodiesterase 4b in complex wi vardenafil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (323 residues) CATH domain: 1.10.1300.10
1y2b
Catalytic domain of human phosphodiesterase 4d in complex wi dimethyl-1h-pyrazole-4-carboxylic acid ethyl ester
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
1y2c
Catalytic domain of human phosphodiesterase 4d in complex wi dimethyl-1-phenyl-1h-pyrazole-4-carboxylic acid ethyl ester
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
1y2d
Catalytic domain of human phosphodiesterase 4d in complex wi methoxy-phenyl)-3,5-dimethyl-1h-pyrazole-4-carboxylic acid ester
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
1y2e
Catalytic domain of human phosphodiesterase 4d in complex wi amino-phenyl)-3,5-dimethyl-1h-pyrazole-4-carboxylic acid et
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
1y2h
Catalytic domain of human phosphodiesterase 4b in complex wi chloro-phenyl)-3,5-dimethyl-1h-pyrazole-4-carboxylic acid e
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domain: 1.10.1300.10
1y2j
Catalytic domain of human phosphodiesterase 4b in complex wi dimethyl-1-(3-nitro-phenyl)-1h-pyrazole-4-carboxylic acid e
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (323 residues) CATH domain: 1.10.1300.10
1y2k
Catalytic domain of human phosphodiesterase 4d in complex wi dimethyl-1-(3-nitro-phenyl)-1h-pyrazole-4-carboxylic acid e
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
1zkl
Multiple determinants for inhibitor selectivity of cyclic nucleotide phosphodiesterases
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde7a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (317 residues) CATH domain: 1.10.1300.10
1zkn
Structure of pde4d2-ibmx
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B, C, D (334 residues) CATH domain: 1.10.1300.10
2fm0
Crystal structure of pde4d in complex with l-869298
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (334 residues) CATH domain: 1.10.1300.10
2fm5
Crystal structure of pde4d2 in complex with inhibitor l- 869299
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (334 residues) CATH domain: 1.10.1300.10
2pw3
Structure of the pde4d-camp complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (327 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group CMP is 52.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
2qyk
Crystal structure of pde4a10 in complex with inhibitor npv
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4a. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (334 residues) CATH domain: 1.10.1300.10
2qyl
Crystal structure of pde4b2b in complex with inhibitor npv
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (335 residues) CATH domain: 1.10.1300.10
2qym
Crystal structure of unliganded pde4c2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4c2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (291 residues) CATH domain: 1.10.1300.10
2qyn
Crystal structure of pde4d2 in complex with inhibitor npv
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (326 residues) CATH domain: 1.10.1300.10
3d3p
Crystal structure of pde4b catalytic domain in complex with a pyrazolopyridine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b, dpde4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (336 residues) CATH domain: 1.10.1300.10
3ecm
Crystal structure of the unliganded pde8a catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde8a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (338 residues) CATH domain: 1.10.1300.10
3ecn
Crystal structure of pde8a catalytic domain in complex with ibmx
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde8a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (338 residues) CATH domain: 1.10.1300.10
3frg
Catalytic domain of human phosphodiesterase 4b2b in complex with a quinoline inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (335 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group GOL is 46.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
3g3n
Pde7a catalytic domain in complex with 3-(2,6- difluorophenyl)-2-(methylthio)quinazolin-4(3h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde7a, pde7a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (318 residues) CATH domain: 1.10.1300.10
3g45
Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b, dpde4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (371 residues) CATH domain: 1.10.1300.10
3g4g
Crystal structure of human phosphodiesterase 4d with regulatory domain and d155871
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B, C, D (338 residues) CATH domain: 1.10.1300.10
3g4i
Crystal structure of human phosphodiesterase 4d with d155871
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D (331 residues) CATH domain: 1.10.1300.10
3g4k
Crystal structure of human phosphodiesterase 4d with rolipram
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D (330 residues) CATH domain: 1.10.1300.10
3g4l
Crystal structure of human phosphodiesterase 4d with roflumilast
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D (327 residues) CATH domain: 1.10.1300.10
3g58
Crystal structure of human phosphodiesterase 4d with d155988/pmnpq
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D (335 residues) CATH domain: 1.10.1300.10
3gwt
Catalytic domain of human phosphodiesterase 4b2b in complex with a quinoline inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b, dpde4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (336 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group GOL is 46.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
3hmv
Catalytic domain of human phosphodiesterase 4b2b in complex tetrahydrobenzothiophene inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b, dpde4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (351 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group GOL is 46.00% similar to enzyme reactant Nucleoside 3',5'-cyclic phosphate
3i8v
Crystal structure of human pde4a with 4-(3-butoxy-4-methoxyp methyl-2-imidazolidone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4a, dpde2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (335 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group GOL is 46.15% similar to enzyme reactant Nucleoside
3iad
Crystal structure of human phosphodiesterase 4d with bound allosteric modulator
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chains: A, B, C, D (340 residues) CATH domain: 1.10.1300.10
3iak
Crystal structure of human phosphodiesterase 4d (pde4d) with papaverine.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domain: 1.10.1300.10
3k4s
The structure of the catalytic domain of human pde4d with 4- (3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (329 residues) CATH domain: 1.10.1300.10
3kkt
Crystal structure of human pde4b with 5-[3-[(1s,2s,4r)- bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1 pyrimidinone reveals ordering of thE C-terminal helix resid 509.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (347 residues) CATH domain: 1.10.1300.10
3ly2
Catalytic domain of human phosphodiesterase 4b in complex wi coumarin-based inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (345 residues) CATH domain: 1.10.1300.10
3o0j
Pde4b in complex with ligand an2898
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (323 residues) CATH domain: 1.10.1300.10
3o56
Catalytic domain of human phosphodiesterase 4b2b in complex heterocycle pyrazolopyridine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b, dpde4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (335 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group GOL is 46.15% similar to enzyme reactant Nucleoside
3o57
Catalytic domain of human phosphodiesterase 4b2b in complex heterocycle pyrazolopyridine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4b, dpde4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (336 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group GOL is 46.15% similar to enzyme reactant Nucleoside
3sl3
Crystal structure of the apo form of the catalytic domain of
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde3, pde4d. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (327 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group PEG is 53.85% similar to enzyme reactant Nucleoside
3sl4
Crystal structure of the catalytic domain of pde4d2 with com
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (329 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group PEG is 53.85% similar to enzyme reactant Nucleoside
3sl5
Crystal structure of the catalytic domain of pde4d2 complexe compound 10d
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde3, pde4d. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (328 residues) CATH domain: 1.10.1300.10
3sl6
Crystal structure of the catalytic domain of pde4d2 with com
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (327 residues) CATH domain: 1.10.1300.10
3sl8
Crystal structure of the catalytic domain of pde4d2 with com
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (327 residues) CATH domain: 1.10.1300.10
Bound ligand:   Het Group PEG is 53.85% similar to enzyme reactant Nucleoside
3tvx
The structure of pde4a with pentoxifylline at 2.84a resoluti
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4a, dpde2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (334 residues) CATH domain: 1.10.1300.10
3v9b
Crystal structure of the catalytic domain of pde4d2 with (s) [1-(3-cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxyp yl)-ethyl]-1h-pyrazl-3-yl}phenyl)acetamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (331 residues) CATH domain: 1.10.1300.10
3w5e
Crystal structure of phosphodiesterase 4b in complex with co
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (345 residues) CATH domain: 1.10.1300.10
3wd9
Crystal structure of phosphodiesterase 4b in complex with co
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (345 residues) CATH domain: 1.10.1300.10
4kp6
Crystal structure of human phosphodiesterase 4b (pde4b) in c with a [1,3,5]triazine derivative
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (324 residues) CATH domain: 1.10.1300.10
4myq
Selective inhibition of the catalytic domain of human phosphodiesterase 4b with a-33
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4, pde4b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (345 residues) CATH domain: 1.10.1300.10
4nw7
Pde4 catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dpde4, pde4, pde4b. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: sf9.
Chain: A (344 residues)
4wcu
Pde4 complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (330 residues)