_EC 3.1.3.67 Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. 2 PDB entries  
EC 3.-.-.- Hydrolases. [17,508 PDB entries]
EC 3.1.-.- Acting on ester bonds. [4,950 PDB entries]
EC 3.1.3.- Phosphoric monoester hydrolases. [1,130 PDB entries]
EC 3.1.3.67 Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. [2 PDB entries]    
1d5r

Pathway: 1-Phosphatidyl-myo-inositol Metabolism
Reaction: Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.
 


Phosphatidylinositol 3,4,5-trisphosphate
+ H(2)O
=
phosphatidylinositol 4,5-bisphosphate
+
phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase.
Cofactor(s): Mg(2+).
Comments: Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3,4,5)P(4) to Ins(1,4,5)P(3).
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 2 PDB entries in enzyme class E.C.3.1.3.67

  PDB code Protein
1d5r
Crystal structure of the pten tumor suppressor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.
Chain: A (307 residues) CATH domains: 3.90.190.10 2.60.40.1110
2kyl
Solution structure of mast2-pdz complexed with thE C-terminu
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Chain: B (13 residues)