_EC 3.1.22.4 Crossover junction endodeoxyribonuclease. 18 PDB entries  
EC 3.-.-.- Hydrolases. [21,435 PDB entries]
EC 3.1.-.- Acting on ester bonds. [6,048 PDB entries]
EC 3.1.22.- Endodeoxyribonucleases producing other than 5'-phosphomonoesters. [18 PDB entries]
EC 3.1.22.4 Crossover junction endodeoxyribonuclease. [18 PDB entries]    
1gef

Reaction: Endonucleolytic cleavage at a junction such as a reciprocal single- stranded crossover between two homologous Dna duplexes (Holliday junction).
Other name(s): Crossover junction endoribonuclease. Cruciform-cutting endonuclease. Endo X3. Endonuclease RuvC. Endonuclease Vii. Endonuclease X3. Hje endonuclease. Holliday junction endonuclease CCE1. Holliday junction nuclease. Holliday junction resolvase.
Comments: The enzyme from Saccharomyces cerevisiae has no endonuclease or exonuclease activity on single-stranded or double-stranded Dna molecules that do not contain Holliday junctions.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 18 PDB entries in enzyme class E.C.3.1.22.4

  PDB code Protein
1gef
Crystal structure of the archaeal holliday junction resolvase hjc
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: hjc. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, D, E (120 residues) CATH domain: 3.40.1350.10
1hh1
The structure of hjc, a holliday junction resolving enzyme from sulfolobus solfataricus
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (125 residues) CATH domain: 3.40.1350.10
1hjr
Atomic structure of the ruvc resolvase: a holliday junction- specific endonuclease from e. Coli
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B, C, D (158 residues) CATH domain: 3.30.420.10
1ipi
Crystal structure of the archaeal holliday junction resolvase hjc from pyrococcus furiosus form ii
Source: Pyrococcus furiosus. Organism_taxid: 2261. Gene: hjc. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (114 residues) CATH domain: 3.40.1350.10
1ob8
Holliday junction resolving enzyme
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: ril. Expression_system_cell_line: bl21.
Chains: A, B (119 residues) CATH domain: 3.40.1350.10
1ob9
Holliday junction resolving enzyme
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: ril. Expression_system_cell_line: bl21.
Chain: A (124 residues) CATH domain: 3.40.1350.10
1q8r
Structure of e.Coli rusa holliday junction resolvase
Source: Escherichia coli. Organism_taxid: 562. Gene: rusa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (118 residues) CATH domain: 3.30.1330.70
2eo0
Crystal structure of holliday junction resolvase st1444
Source: Sulfolobus tokodaii. Organism_taxid: 273063. Strain: 7. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (130 residues) CATH domain: 3.40.1350.10
2h8c
Structure of rusa d70n in complex with DNA
Source: Synthetic: yes. Escherichia coli. Organism_taxid: 562. Gene: rusa, rus. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (117 residues) CATH domain: 3.30.1330.70
2h8e
Structure rusa d70n
Source: Escherichia coli. Organism_taxid: 562. Gene: rusa, rus. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (120 residues) CATH domain: 3.30.1330.70
2wcw
1.6a resolution structure of archaeoglobus fulgidus hjc, a holliday junction resolvase from an archaeal hyperthermophile
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Strain: 4304. Atcc: 49558. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm)
Chains: A, B, C, D (126 residues) CATH domain: 3.40.1350.10
2wcz
1.6a resolution structure of archaeoglobus fulgidus hjc, a holliday junction resolvase from an archaeal hyperthermophile
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Strain: 4304. Atcc: 49558. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm)
Chains: A, B (123 residues) CATH domain: 3.40.1350.10
2wiw
Crystal structures of holliday junction resolvases from archaeoglobus fulgidus bound to DNA substrate
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Strain: 4304. Atcc: 49558. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm). Synthetic: yes. Other_details: synthesized by metabion gmbh, martinsried,
Chains: A, B (120 residues) CATH domain: 3.40.1350.10
2wiz
Crystal structures of holliday junction resolvases from archaeoglobus fulgidus bound to DNA substrate
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Strain: 4304. Atcc: 49558. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm). Synthetic: yes. Other_details: synthesized by metabion gmbh, martinsried,
Chains: A, B (125 residues) CATH domain: 3.40.1350.10
2wj0
Crystal structures of holliday junction resolvases from archaeoglobus fulgidus bound to DNA substrate
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Strain: 4304. Atcc: 49558. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: german collection of microorganisms (dsm). Synthetic: yes. Other_details: synthesized by metabion gmbh, martinsried,
Chains: A, B (125 residues) CATH domain: 3.40.1350.10
4ep4
Thermus thermophilus ruvc structure
Source: Thermus thermophilus. Organism_taxid: 300852. Gene: ruvc, ttha1090. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (166 residues) CATH domain: 3.30.420.10
4ep5
Thermus thermophilus ruvc structure
Source: Thermus thermophilus. Organism_taxid: 300852. Gene: ruvc, ttha1090. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (157 residues) CATH domain: 3.30.420.10
4ld0
T. Thermophilus ruvc in complex with holliday junction subst
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8 / atcc 27634 / dsm 579. Gene: ruvc, ttha1090. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic DNA. Other_details: synthetic DNA
Chains: A, B (158 residues) CATH domain: 3.30.420.10