_EC 3.1.1.4 Phospholipase A(2). 262 PDB entries  
EC 3.-.-.- Hydrolases. [21,051 PDB entries]
EC 3.1.-.- Acting on ester bonds. [5,973 PDB entries]
EC 3.1.1.- Carboxylic ester hydrolases. [961 PDB entries]
EC 3.1.1.4 Phospholipase A(2). [262 PDB entries]    
1a2a

Reaction: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
 


Phosphatidylcholine
+ H(2)O
=
1-acylglycerophosphocholine
+
carboxylate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Lecithinase A. Phosphatidase. Phosphatidolipase. Phosphatidylcholine 2-acylhydrolase. Phospholipase A2.
Cofactor(s): Ca(2+).
Comments: Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 262 PDB entries in enzyme class E.C.3.1.1.4

  PDB code Protein
1a2a
Agkistrotoxin, a phospholipase a2-type presynaptic neurotoxin from agkistrodon halys pallas
Source: Gloydius halys. Halys viper. Organism_taxid: 8714
Chains: A, B, C, D, E, F, G, H (122 residues) CATH domain: 1.20.90.10
1a3d
Phospholipase a2 (pla2) from naja naja venom
Source: Naja naja. Indian cobra. Organism_taxid: 35670. Cellular_location: venom sack
Chain: A (119 residues) CATH domain: 1.20.90.10
1a3f
Phospholipase a2 (pla2) from naja naja venom
Source: Naja naja. Indian cobra. Organism_taxid: 35670. Cellular_location: venom sack
Chains: A, B, C (119 residues) CATH domain: 1.20.90.10
1ae7
Notexin, a presynaptic neurotoxic phospholipase a2
Source: Notechis scutatus scutatus. Organism_taxid: 70142. Strain: scutatus. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
1aok
Vipoxin complex
Source: Vipera ammodytes meridionalis. Organism_taxid: 73841. Strain: meridionalis. Secretion: venom. Secretion: venom
Chain: B (122 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylic acid
1ayp
A probe molecule composed of seventeen percent of total diffracting matter gives correct solutions in molecular replacement
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B, C, D, E, F (124 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group INB is 51.00% similar to enzyme reactant Phosphatidylcholine
1b4w
Basic phospholipase a2 from agkistrodon halys pallas- implications for its association and anticoagulant activities by x-ray crystallography
Source: Gloydius halys. Halys viper. Organism_taxid: 8714. Secretion: yes. Cellular_location: extracellular
Chains: A, B, C, D (122 residues) CATH domain: 1.20.90.10
1bbc
Structure of recombinant human rheumatoid arthritic synovial phospholipase a2 at 2.2 angstroms resolution
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (124 residues) CATH domain: 1.20.90.10
1bci
C2 domain of cytosolic phospholipase a2, nmr, minimized average structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: proprietary strain/gi400. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: proprietary strain/gi400.
Chain: A (123 residues) CATH domain: 2.60.40.150
1bjj
Agkistrodotoxin, a phospholipase a2-type presynaptic neurotoxin from agkistrodon halys pallas
Source: Gloydius halys. Halys viper. Organism_taxid: 8714. Secretion: venom. Other_details: the snake is also named agkistrodon blomhoffii brevicaudus
Chains: A, B, C, D, E, F (122 residues) CATH domain: 1.20.90.10
1bk9
Phospholipase a2 modified by pbpb
Source: Gloydius halys. Halys viper. Organism_taxid: 8714
Chain: A (124 residues) CATH domain: 1.20.90.10
1bp2
Structure of bovine pancreatic phospholipase a2 at 1.7 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (123 residues) CATH domain: 1.20.90.10
1bpq
Phospholipase a2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (123 residues) CATH domain: 1.20.90.10
1bun
Structure of beta2-bungarotoxin: potassium channel binding by kunitz modules and targeted phospholipase action
Source: Bungarus multicinctus. Many-banded krait. Organism_taxid: 8616. Tissue: venom. Tissue: venom
Chain: A (120 residues) CATH domain: 1.20.90.10
1bvm
Solution nmr structure of bovine pancreatic phospholipase a2, 20 structures
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: bovine pancreas
Chain: A (123 residues) CATH domain: 1.20.90.10
1c1j
Structure of cadmium-substituted phospholipase a2 from agkistrondon halys pallas at 2.8 angstroms resolution
Source: Gloydius halys. Halys viper. Organism_taxid: 8714
Chains: A, B, C, D (122 residues) CATH domain: 1.20.90.10
1c74
Structure of the double mutant (k53,56m) of phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: pancreas
Chain: A (123 residues) CATH domain: 1.20.90.10
1ceh
Structure and function of the catalytic site mutant asp99asn of phospholipase a2: absence of conserved structural water
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (123 residues) CATH domain: 1.20.90.10
1cjy
Human cytosolic phospholipase a2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (633 residues) CATH domains: 2.60.40.150 3.40.1090.10
1cl5
Crystal structure of phospholipase a2 from daboia russelli pulchella
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom
Chains: A, B (121 residues) CATH domain: 1.20.90.10
1db4
Human s-pla2 in complex with indole 8
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (124 residues) CATH domain: 1.20.90.10
1db5
Human s-pla2 in complex with indole 6
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (124 residues) CATH domain: 1.20.90.10
1dcy
Crystal structure of human s-pla2 in complex with indole 3 active site inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (124 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group I3N is 48.00% similar to enzyme product carboxylate
1dpy
Three-dimensional structure of a novel phospholipase a2 from indian common krait at 2.45 a resolution
Source: Bungarus caeruleus. Organism_taxid: 132961. Secretion: venom
Chain: A (117 residues) CATH domain: 1.20.90.10
1fb2
Structure of phospholipase a2 from daboia russelli pulchella at 1.95
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom
Chains: A, B (121 residues) CATH domain: 1.20.90.10
1fdk
Carboxylic ester hydrolase (pla2-mj33 inhibitor complex)
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1fe5
Sequence and crystal structure of a basic phospholipase a2 from common krait (bungarus caeruleus) at 2.4 resolution: identification and characterization of its pharmacological sites.
Source: Bungarus caeruleus. Organism_taxid: 132961. Secretion: venom
Chain: A (118 residues) CATH domain: 1.20.90.10
1fv0
First structural evidence of the inhibition of phospholipase aristolochic acid: crystal structure of a complex formed be phospholipase a2 and aristolochic acid
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom
Chains: A, B (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylic
1fw2
Outer membrane phospholipase a from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (257 residues) CATH domain: 2.40.230.10
1fw3
Outer membrane phospholipase a from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (250 residues) CATH domain: 2.40.230.10
1fx9
Carboxylic ester hydrolase complex (dimeric pla2 + mj33 inhibitor + sulphate ions)
Source: Sus scrofa. Pig. Organism_taxid: 9823. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (124 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group MJI is 40.00% similar to enzyme reactant Phosphatidylcholine
1fxf
Carboxylic ester hydrolase complex (dimeric pla2 + mj33 inhibitor + phosphate ions)
Source: Sus scrofa. Pig. Organism_taxid: 9823. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (124 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group MJI is 40.00% similar to enzyme reactant Phosphatidylcholine
1g0z
Specific mutations in krait pla2 lead to dimerization of protein molecules: crystal structure of krait pla2 at 2.1 resolution
Source: Bungarus caeruleus. Organism_taxid: 132961. Secretion: venom. Other_details: natural protein-isoform
Chains: A, B (118 residues) CATH domain: 1.20.90.10
1g2x
Sequence induced trimerization of krait pla2: crystal structure of the trimeric form of krait pla2
Source: Bungarus caeruleus. Organism_taxid: 132961. Secretion: venom. Other_details: natural protein-isoform
Chains: A, B, C (118 residues) CATH domain: 1.20.90.10
1g4i
Crystal structure of the bovine pancreatic phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (123 residues) CATH domain: 1.20.90.10
1gh4
Structure of the triple mutant (k56m, k120m, k121m) of phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (123 residues) CATH domain: 1.20.90.10
1gmz
Crystal structure of the d49 phospholipase a2 piratoxin iii from bothrops pirajai.
Source: Bothrops pirajai. Snake. Organism_taxid: 113192. Secretion: venom
Chains: A, B (119 residues) CATH domain: 1.20.90.10
1gp7
Acidic phospholipase a2 from venom of ophiophagus hannah
Source: Ophiophagus hannah. King cobra. Organism_taxid: 8665. Tissue: venom. Other_details: snake venom
Chains: A, B, C (124 residues) CATH domain: 1.20.90.10
1hn4
Prophospholipase a2 dimer complexed with mj33, sulfate, and calcium
Source: Sus scrofa. Pig. Organism_taxid: 9823. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (129 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group MJI is 40.00% similar to enzyme reactant Phosphatidylcholine
1ijl
Crystal structure of acidic phospholipase a2 from deinagkistrodon acutus
Source: Deinagkistrodon acutus. Chinese moccasin. Organism_taxid: 36307
Chains: A, B (123 residues) CATH domain: 1.20.90.10
1ild
Outer membrane phospholipase a from escherichia coli n156a active site mutant ph 4.6
Source: Escherichia coli. Organism_taxid: 562. Gene: plda. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (257 residues) CATH domain: 2.40.230.10
1ilz
Outer membrane phospholipase a from escherichia coli n156a active site mutant ph 6.1
Source: Escherichia coli. Organism_taxid: 562. Gene: plda. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (257 residues) CATH domain: 2.40.230.10
1im0
Outer membrane phospholipase a from escherichia coli n156a active site mutant ph 8.3
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (262 residues) CATH domain: 2.40.230.10
1irb
Carboxylic ester hydrolase
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1j1a
Pancreatic secretory phospholipase a2 (iia) with anti- inflammatory activity
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (124 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group BHP is 40.00% similar to enzyme product carboxylate
1jia
Structure of a basic phospholipase a2 from agkistrodon halys pallas at 2.13a resolution
Source: Gloydius halys. Halys viper. Organism_taxid: 8714. Secretion: venom. Cellular_location: extracellular
Chains: A, B (122 residues) CATH domain: 1.20.90.10
1jlt
Vipoxin complex
Source: Vipera ammodytes ammodytes. Western sand viper. Organism_taxid: 8705. Strain: ammodytes. Other_details: sequence homology between phospholipase and its inhibitor in snake venom. The primary structure of phospholipase a2 of vipoxin from the venom of the bulgarian viper (vipera ammodytes ammodytes, serpentes)
Chain: B (122 residues) CATH domain: 1.20.90.10
1jq8
Design of specific inhibitors of phospholipase a2: crystal s of a complex formed between phospholipase a2 from daboia ru pulchella and a designed pentapeptide leu-ala-ile-tyr-ser a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Synthetic: yes. Other_details: the sequence was chemically synthesized.
Chains: A, B (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic
1jq9
Crystal structure of a complex formed between phospholipase daboia russelli pulchella and a designed pentapeptide phe-l tyr-lys at 1.8 resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Synthetic: yes. Other_details: the sequence was chemically synthesized.
Chains: A, B (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic
1kpm
First structural evidence of a specific inhibition of phosph by vitamin e and its implications in inflammation: crystal of the complex formed between phospholipase a2 and vitamin resolution.
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom
Chains: A, B (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic
1kqu
Human phospholipase a2 complexed with a substrate anologue
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (124 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group BR4 is 48.00% similar to enzyme product carboxylate
1kvo
Human phospholipase a2 complexed with a highly potent substrate anologue
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells
Chains: A, B, C, D, E, F (124 residues) CATH domain: 1.20.90.10
1kvw
Carboxylic ester hydrolase, single mutant h48q of bovine pancreatic pla2 enzyme
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1kvx
Carboxylic ester hydrolase, single mutant d99a of bovine pancreatic pla2, 1.9 a orthorhombic form
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1kvy
Carboxylic ester hydrolase, single mutant d49e coordinated to calcium
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1l8s
Carboxylic ester hydrolase complex (dimeric pla2 + lpc- ether + acetate + phosphate ions)
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: pancreas. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (124 residues) CATH domain: 1.20.90.10
Bound ligands:   Het Group LPE is 69.00% similar to enzyme reactant Phosphatidylcholine
  Het Group ACT is 60.00% similar to enzyme product carboxylic acid
1le6
Carboxylic ester hydrolase, p 1 21 1 space group
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2gx10. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (123 residues) CATH domain: 1.20.90.10
1le7
Carboxylic ester hydrolase, c 2 2 21 space group
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2gx10. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (123 residues) CATH domain: 1.20.90.10
1lff
Crystal structure of an acidic phospholipase a2 from naja naja sagittifera at 1.5 a resolution
Source: Naja naja sagittifera. Indian cobra. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
1lfj
X-ray crystal structure of a complex formed between two homologous isoforms of phospholipase a2 from naja naja sagittifera: principle of molecular association and inactivation
Source: Naja naja sagittifera. Indian cobra. Secretion: venom. Secretion: venom
Chains: A, B (119 residues) CATH domain: 1.20.90.10
1ln8
Crystal structure of a new isoform of phospholipase a2 from naja naja sagittifera at 1.6 a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
1lx1
Prediction of three-dimensional structure of phospholipase a2, taipoxin alpha chain (presynaptic neurotoxin) from australian snake taipan (oxyuranus scutellatus scutellatus) by homology modeling
Source: Oxyuranus scutellatus scutellatus. Australian taipan
Chain: A (119 residues)
1m8r
Crystal structures of cadmium-binding acidic phospholipase a2 from the venom of agkistrodon halys pallas at 1.9 resolution (crystal grown at ph 7.4)
Source: Gloydius halys. Halys viper. Organism_taxid: 8714. Secretion: venom
Chain: A (124 residues) CATH domain: 1.20.90.10
1m8s
Crystal structures of cadmium-binding acidic phospholipase a2 from the venom of agkistrodon halys pallas at 1.9 resolution (crystal grown at ph 5.9)
Source: Gloydius halys. Halys viper. Organism_taxid: 8714. Secretion: venom
Chain: A (124 residues) CATH domain: 1.20.90.10
1m8t
Structure of an acidic phospholipase a2 from the venom of ophiophagus hannah at 2.1 resolution from a hemihedrally twinned crystal form
Source: Ophiophagus hannah. King cobra. Organism_taxid: 8665. Secretion: venom
Chains: A, B, C, D, E, F (119 residues) CATH domain: 1.20.90.10
1mf4
Structure-based design of potent and selective inhibitors of phospholipase a2: crystal structure of the complex formed b phosholipase a2 from naja naja sagittifera and a designed p inhibitor at 1.9 a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom. Synthetic: yes. Other_details: this peptide was chemically synthesized.
Chain: A (119 residues) CATH domain: 1.20.90.10
1mh2
Crystal structure of a zinc containing dimer of phospholipase a2 from the venom of indian cobra (naja naja sagittifera)
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom. Secretion: venom
Chains: A, B (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
1mh7
Crystal structure of a calcium-free isoform of phospholipase a2 from naja naja sagittifera at 2.0 a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
1mh8
Crystal structure of a phopholipase a2 monomer with isoleucine at second position
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
1mks
Carboxylic ester hydrolase, trigonal form of the triple mutant
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: pro-pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1mkt
Carboxylic ester hydrolase, 1.72 angstrom trigonal form of the bovine recombinant pla2 enzyme
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1mku
Carboxylic ester hydrolase, orthorhombic form of the triple mutant
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: pro-pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1mkv
Carboxylic ester hydrolase complex (pla2 + transition state analog complex)
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreas. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1n28
Crystal structure of the h48q mutant of human group iia phospholipase a2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: B, A (124 residues) CATH domain: 1.20.90.10
1n29
Crystal structure of the n1a mutant of human group iia phospholipase a2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (124 residues) CATH domain: 1.20.90.10
1o2e
Structure of the triple mutant (k53,56,120m) + anisic acid complex of phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1o3w
Structure of the inhibitor free triple mutant (k53,56,120m) of phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1oo1
3d-structure of naja melanoreuca isolate isozyme phospholipase a2
Source: Naja melanoleuca. Forest cobra
Chain: A (118 residues)
1oqs
Crystal structure of rv4/rv7 complex
Source: Daboia russellii siamensis. Organism_taxid: 343250. Strain: siamensis. Secretion: venom. Secretion: venom
Chains: A, B, C, D, E, F, G, H (122 residues) CATH domain: 1.20.90.10
1ows
Crystal structure of a c49 phospholipase a2 from indian cobr carbohydrate binding in the hydrophobic channel
Source: Naja naja. Indian cobra. Organism_taxid: 35670. Secretion: venom. Secretion: venom
Chains: A, B (118 residues) CATH domain: 1.20.90.10
1oxl
Inhibition of phospholipase a2 (pla2) by (2-carbamoylmethyl- 5-propyl-octahydro-indol-7-yl)-acetic acid (indole): crystal structure of the complex formed between pla2 from russell's viper and indole at 1.8 resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Secretion: venom
Chains: A, B (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group CO3 is 60.00% similar to enzyme product carboxylic acid
1oxr
Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase a2: crystal structure of the complex formed between phospholipase a2 and aspirin at 1.9a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
1oyf
Crystal structure of russelles viper (daboia russellii pulchella) phospholipase a2 in a complex with venom 6- methyl heptanol
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom. Secretion: venom
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
1oz6
X-ray structure of acidic phospholipase a2 from indian saw- scaled viper (echis carinatus) with a potent platelet aggregation inhibitory activity
Source: Echis carinatus. Saw-scaled viper. Organism_taxid: 40353. Secretion: venom
Chain: A (120 residues) CATH domain: 1.20.90.10
1ozy
Crystal structure of phospholipase a2 (mipla3) from micropec ikaheka
Source: Micropechis ikaheka. Organism_taxid: 66188
Chains: A, B (121 residues) CATH domain: 1.20.90.10
1p2p
Structure of porcine pancreatic phospholipase a2 at 2.6 angs resolution and comparison with bovine phospholipase a2
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (124 residues) CATH domain: 1.20.90.10
1p7o
Crystal structure of phospholipase a2 (mipla4) from micropec ikaheka
Source: Micropechis ikaheka. Organism_taxid: 66188
Chains: A, B, C, D, E, F (124 residues) CATH domain: 1.20.90.10
1pir
Solution structure of porcine pancreatic phospholipase a2
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: pancreas
Chain: A (124 residues) CATH domain: 1.20.90.10
1pis
Solution structure of porcine pancreatic phospholipase a2
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: pancreas
Chain: A (124 residues) CATH domain: 1.20.90.10
1po8
Crystal structure of a complex formed between krait venom phospholipase a2 and heptanoic acid at 2.7 a resolution.
Source: Bungarus caeruleus. Organism_taxid: 132961. Other_details: venom protein
Chain: A (118 residues) CATH domain: 1.20.90.10
1poa
Interfacial catalysis: the mechanism of phospholipase a2
Source: Naja atra. Chinese cobra. Organism_taxid: 8656
Chain: A (118 residues) CATH domain: 1.20.90.10
1pob
Crystal structure of cobra-venom phospholipase a2 in a complex with a transition-state analogue
Source: Naja atra. Chinese cobra. Organism_taxid: 8656
Chains: A, B (118 residues) CATH domain: 1.20.90.10
1poc
Crystal structure of bee-venom phospholipase a2 in a complex with a transition-state analogue
Source: Apis mellifera. Honey bee. Organism_taxid: 7460
Chain: A (134 residues) CATH domain: 1.20.90.10
1pod
Structures of free and inhibited human secretory phospholipa inflammatory exudate
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (124 residues) CATH domain: 1.20.90.10
1poe
Structures of free and inhibited human secretory phospholipase a2 from inflammatory exudate
Source: Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (124 residues) CATH domain: 1.20.90.10
1pp2
The refined crystal structure of dimeric phospholipase a2 at 2.5 angstroms. Access to a shielded catalytic center
Source: Crotalus atrox. Western diamondback rattlesnake. Organism_taxid: 8730
Chains: R, L (122 residues) CATH domain: 1.20.90.10
1psh
Crystal structure of phospholipase a2 from indian cobra reveals a trimeric association
Source: Naja naja. Indian cobra. Organism_taxid: 35670
Chains: A, B, C (119 residues) CATH domain: 1.20.90.10
1psj
Acidic phospholipase a2 from agkistrodon halys pallas
Source: Gloydius halys. Halys viper. Organism_taxid: 8714. Secretion: venom
Chain: A (124 residues) CATH domain: 1.20.90.10
1pwo
Crystal structure of phospholipase a2 (mipla2) from micropechis ikaheka
Source: Micropechis ikaheka. Organism_taxid: 66188. Secretion: venom
Chains: A, B, C, D (124 residues) CATH domain: 1.20.90.10
1q6v
First crystal structure of a c49 monomer pla2 from the venom russelli pulchella at 1.8 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Other_details: venom secretion
Chain: A (121 residues) CATH domain: 1.20.90.10
1q7a
Crystal structure of the complex formed between russell's vi phospholipase a2 and an antiinflammatory agent oxyphenbutaz 1.6a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Other_details: venom secretion
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group MOH is 50.00% similar to enzyme product carboxylic
1qd5
Outer membrane phospholipase a from escherichia coli
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: escherichia coli, outer membrane
Chain: A (257 residues) CATH domain: 2.40.230.10
1qd6
Outer membrane phospholipase a from escherichia coli
Source: Synthetic: yes. Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (13 residues)
1rgb
Phospholipase a2 from vipera ammodytes meridionalis
Source: Vipera ammodytes meridionalis. Organism_taxid: 73841. Strain: meridionalis. Secretion: venom
Chains: A, B, K, L (122 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ELD is 64.00% similar to enzyme product carboxylate
1rlw
Calcium-phospholipid binding domain from cytosolic phospholipase a2
Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytosol. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: de3.
Chain: A (126 residues) CATH domain: 2.60.40.150
1s6b
X-ray crystal structure of a complex formed between two homologous isoforms of phospholipase a2 from naja naja sagittifera: principle of molecular association and inactivation
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom. Secretion: venom
Chains: A, B (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
1sfv
Porcine pancreas phospholipase a2, nmr, minimized average structure
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: pancreas. Gene: porcine pancreas pla2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression plasmid). Other_details: details concerning the expression of the
Chain: A (124 residues) CATH domain: 1.20.90.10
1sfw
Porcine pancreas phospholipase a2, nmr, 18 structures
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: pancreas. Gene: porcine pancreas pla2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression plasmid). Other_details: details concerning the expression of the
Chain: A (124 residues) CATH domain: 1.20.90.10
1skg
Structure-based rational drug design: crystal structure of the complex formed between phospholipase a2 and a pentapeptide val-ala-phe-arg-ser
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom. Synthetic: yes. Other_details: the sequence was chemically synthesized.
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group MOH is 50.00% similar to enzyme product carboxylic acid
1sqz
Design of specific inhibitors of phopholipase a2: crystal st the complex formed between group ii phopholipase a2 and a d peptide dehydro-ile-ala-arg-ser at 1.2a resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Synthetic: yes. Other_details: solid phase synthesis
Chain: A (121 residues) CATH domain: 1.20.90.10
1sv3
Structure of the complex formed between phospholipase a2 and 4-methoxybenzoic acid at 1.3a resolution.
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
1sv9
Crystal structure of the complex formed between groupii phospholipase a2 and anti-inflammatory agent 2-[(2,6- dichlorophenyl)amino] benzeneacetic acid at 2.7a resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Secretion: venom
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group DIF is 40.00% similar to enzyme product carboxylate
1sxk
Crystal structure of a complex formed between phospholipase a2 and a non-specific anti-inflammatory amino salicylic acid at 1.2 a resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Secretion: venom
Chain: A (121 residues) CATH domain: 1.20.90.10
1sz8
Crystal structure of an acidic phospholipase a2 from naja na sagittifera at 1.5 a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylate
1t37
Design of specific inhibitors of phospholipase a2: crystal structure of the complex formed between group i phospholipase a2 and a designed pentapeptide leu-ala-ile- tyr-ser at 2.6a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom. Synthetic: yes
Chain: A (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylic acid
1tc8
Crystal structure of krait-venom phospholipase a2 in a complex with a natural fatty acid tridecanoic acid
Source: Bungarus caeruleus. Organism_taxid: 132961. Secretion: venom
Chain: A (118 residues) CATH domain: 1.20.90.10
1td7
Interactions of a specific non-steroidal anti-inflammatory drug (nsaid) with group i phospholipase a2 (pla2): crystal structure of the complex formed between pla2 and niflumic acid at 2.5 a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
1tdv
Non-specific binding to phospholipase a2:crystal structure of the complex of pla2 with a designed peptide tyr-trp-ala- ala-ala-ala at 1.7a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Synthetic: yes. Other_details: ywaaaa peptide sequence was chemically synthesized
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group TRP is 42.00% similar to enzyme product carboxylate
1tg1
Crystal structure of the complex formed between russells vip phospholipase a2 and a designed peptide inhibitor phq-leu-v at 1.2a resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Tissue: snake venom. Synthetic: yes
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic
1tg4
Design of specific inhibitors of groupii phospholipase a2(pla2): crystal structure of the complex formed between russells viper pla2 and designed peptide phe-leu-ala-tyr- lys at 1.7a resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Tissue: snake venom. Synthetic: yes
Chain: A (121 residues) CATH domain: 1.20.90.10
1tgm
Crystal structure of a complex formed between group ii phospholipase a2 and aspirin at 1.86 a resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Tissue: snake venom
Chain: A (121 residues) CATH domain: 1.20.90.10
1th6
Crystal structure of phospholipase a2 in complex with atropine at 1.23a resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Tissue: venom secretion
Chain: A (121 residues) CATH domain: 1.20.90.10
1ti0
Binding of non-steroidal anti-inflammatory drugs to phospholipase a2: crystal structure of the complex formed between phospholipase a2 and indomethacin at 1.4a resolution.
Source: Daboia russelli russelli. Russell's viper. Tissue: snake venom
Chain: A (121 residues) CATH domain: 1.20.90.10
1tj9
Structure of the complexed formed between group ii phospholipase a2 and a rationally designed tetra peptide, val-ala-arg-ser at 1.1a resolution
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Tissue: snake venom. Synthetic: yes. Other_details: vars-solid phase peptide synthesis
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
1tjk
Crystal structure of the complex formed between group ii phospholipase a2 with a designed pentapeptide, phe- leu- ser- thr- lys at 1.2 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Tissue: venom. Synthetic: yes
Chain: A (121 residues) CATH domain: 1.20.90.10
1tjq
Crystal structure of the complex formed between a group ii phospholipase a2 and designed peptide inhibitor carbobenzoxy-dehydro-val-ala-arg-ser at 1.2 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: snake venom. Synthetic: yes. Other_details: the peptide was chemically synthesized
Chain: A (121 residues) CATH domain: 1.20.90.10
1tk4
Crystal structure of russells viper phospholipase a2 in complex with a specifically designed tetrapeptide ala-ile- arg-ser at 1.1 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom. Synthetic: yes. Other_details: the peptide has been synthesized chemically
Chain: A (121 residues) CATH domain: 1.20.90.10
1tp2
Crystal structure of the complex of group ii phospholipasea2 dimer with a fatty acid tridecanoic acid at 2.4 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom
Chains: A, B (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
1u4j
Crystal structure of a carbohydrate induced dimer of group i phospholipase a2 from bungarus caeruleus at 2.1 a resolution
Source: Bungarus caeruleus. Organism_taxid: 132961
Chains: A, B (118 residues) CATH domain: 1.20.90.10
1u73
Crystal structure of a dimeric acidic platelet aggregation inhibitor and hypotensive phospholipase a2 from bothrops jararacussu
Source: Bothrops jararacussu. Jararacussu. Organism_taxid: 8726. Other_details: venom glands
Chains: A, B (122 residues) CATH domain: 1.20.90.10
1umv
Crystal structure of an acidic, non-myotoxic phospholipase a2 from the venom of bothrops jararacussu
Source: Bothrops jararacussu. Jararacussu. Organism_taxid: 8726. Secretion: venom
Chain: X (122 residues) CATH domain: 1.20.90.10
1une
Carboxylic ester hydrolase, 1.5 angstrom orthorhombic form of the bovine recombinant pla2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Cell_line: bl21. Organ: pancreatic. Gene: mature pla2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1vap
The monomeric asp49 secretory phospholipase a2 from the venom of agkistridon piscivorus piscivorus
Source: Agkistrodon piscivorus piscivorus. Eastern cottonmouth. Organism_taxid: 8716. Strain: piscivorus
Chains: A, B (123 residues) CATH domain: 1.20.90.10
1vip
Anticoagulant class ii phospholipase a2 from the venom of vi russelli russelli
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii. Secretion: venom. Other_details: miami serpentarium
Chain: A (121 residues) CATH domain: 1.20.90.10
1vkq
A re-determination of the structure of the triple mutant (k53,56,120m) of phospholipase a2 at 1.6a resolution using sulphur-sas at 1.54a wavelength
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
1vl9
Atomic resolution (0.97a) structure of the triple mutant (k53,56,121m) of bovine pancreatic phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (123 residues) CATH domain: 1.20.90.10
1xxw
Structure of zinc induced heterodimer of two calcium free isoforms of phospholipase a2 from naja naja sagittifera at 2.7a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Secretion: venom. Secretion: venom
Chains: A, B (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
1y38
Crystal structure of the complex formed between phospholipase a2 dimer and glycerophosphate at 2.4 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom
Chains: A, B (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group G3P is 52.00% similar to enzyme product 1-acyl-sn-glycero-3-phosphocholine
1y6o
Crystal structure of disulfide engineered porcine pancreatic phospholipase a2 to group-x isozyme in complex with inhibit and phosphate ions
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (131 residues) CATH domain: 1.20.90.10
1y6p
Crystal structure of disulfide engineered porcine pancratic phospholipase a2 to group-x isozyme
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (131 residues) CATH domain: 1.20.90.10
1y75
A new form of catalytically inactive phospholipase a2 with a disulphide bridge cys 32- cys 49 reveals recognition for n- acetylglucosmine
Source: Naja sagittifera. Organism_taxid: 195058. Organism_taxid: 195058
Chains: A, B (118 residues) CATH domain: 1.20.90.10
1ysk
Modeled structure of human pancreatic phospholipase a2 bound to a phospholipid membrane
Source: Homo sapiens. Human. Gene: pla2g1b, pla2, pla2a. Expressed in: escherichia coli.
Chain: A (124 residues)
1yxh
Crystal structure of a novel phospholipase a2 from naja naja sagittifera with a strong anticoagulant activity
Source: Naja sagittifera. Organism_taxid: 195058
Chain: A (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group EOH is 40.00% similar to enzyme product carboxylic acid
1yxl
Crystal structure of a novel phospholipase a2 from naja naja sagittifera at 1.5 a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Tissue: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
1z76
Crystal structure of an acidic phospholipase a2 (btha-i) from bothrops jararacussu venom complexed with p- bromophenacyl bromide
Source: Bothrops jararacussu. Jararacussu. Organism_taxid: 8726. Secretion: venom
Chains: A, B (122 residues) CATH domain: 1.20.90.10
1zl7
Crystal structure of catalytically-active phospholipase a2 w calcium
Source: Bothrops jararacussu. Jararacussu. Organism_taxid: 8726. Other_details: venom
Chain: A (122 residues) CATH domain: 1.20.90.10
1zlb
Crystal structure of catalytically-active phospholipase a2 in the absence of calcium
Source: Bothrops jararacussu. Jararacussu. Organism_taxid: 8726. Other_details: venom
Chain: A (122 residues) CATH domain: 1.20.90.10
1zm6
Crystal structure of the complex formed beween a group i phospholipase a2 and designed penta peptide leu-ala-ile- tyr-ser at 2.6a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Synthetic: yes. Other_details: chemically synthesized.
Chain: A (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylic acid
1zr8
Crystal structure of the complex formed between group ii phospholipase a2 and a plant alkaloid ajmaline at 2.0a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Other_details: venom
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
1zwp
The atomic resolution crystal structure of the phospholipase a2 (pla2) complex with nimesulide reveals its weaker binding to pla2
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: viper russells
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group MOH is 50.00% similar to enzyme product carboxylic acid
1zyx
Crystal structure of the complex of a group iia phospholipase a2 with a synthetic anti-inflammatory agent licofelone at 1.9a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group LCF is 51.00% similar to enzyme product carboxylate
2arm
Crystal structure of the complex of phospholipase a2 with a compound atropine at 1.2 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
2azy
Crystal structure of porcine pancreatic phospholipase a2 in with cholate
Source: Sus scrofa. Pig. Organism_taxid: 9823. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (124 residues) CATH domain: 1.20.90.10
2azz
Crystal structure of porcine pancreatic phospholipase a2 in with taurocholate
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (124 residues) CATH domain: 1.20.90.10
2b00
Crystal structure of porcine pancreatic phospholipase a2 in with glycocholate
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (124 residues) CATH domain: 1.20.90.10
2b01
Crystal structure of porcine pancreatic phospholipase a2 in with taurochenodeoxycholate
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (124 residues) CATH domain: 1.20.90.10
2b03
Crystal structure of porcine pancreatic phospholipase a2 in with taurochenodeoxycholate
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (124 residues) CATH domain: 1.20.90.10
2b04
Crystal structure of porcine pancreatic phospholipase a2 in with glycochenodeoxycholate
Source: Sus scrofa. Pig. Organism_taxid: 9823. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (118 residues) CATH domain: 1.20.90.10
2b17
Specific binding of non-steroidal anti-inflammatory drugs (nsaids) to phospholipase a2: crystal structure of the complex formed between phospholipase a2 and diclofenac at 2.7 a resolution:
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group DIF is 40.00% similar to enzyme product carboxylate
2b96
Third calcium ion found in an inhibitor bound phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
2bax
Atomic resolution structure of the double mutant (k53,56m) of bovine pancreatic phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
2bch
A possible of second calcium ion in interfacial binding: atomic and medium resolution crystal structures of the quadruple mutant of phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (123 residues) CATH domain: 1.20.90.10
2bd1
A possible role of the second calcium ion in interfacial binding: atomic and medium resolution crystal structures of the quadruple mutant of phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (123 residues) CATH domain: 1.20.90.10
2bp2
The structure of bovine pancreatic prophospholipase a2 at 3.0 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (123 residues) CATH domain: 1.20.90.10
2bpp
Phospholipase a2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Chain: A (123 residues) CATH domain: 1.20.90.10
2do2
Design of specific inhibitors of phospholipase a2: crystal structure of the complex formed between a group ii cys 49 phospholipase a2 and a designed pentapeptide ala-leu-ala- ser-lys at 2.6a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Synthetic: yes. Other_details: the peptide was chemically synthesized.
Chain: A (121 residues) CATH domain: 1.20.90.10
2dpz
Structure of the complex of phospholipase a2 with n-(4- hydroxyphenyl)- acetamide at 2.1 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
2dv8
Crystal structure of phospholipase a2 complex with indomethacin at 1.4 a resolution reveals a novel non- competitive ligand binding site
Source: Daboia russellii russellii. Organism_taxid: 31159. Strain: russellii
Chain: A (121 residues) CATH domain: 1.20.90.10
2fnx
Design of specific peptide inhibitors of phospholipase a2 (pla2): crystal structure of the complex of pla2 with a highly potent peptide val-ile-ala-lys at 2.7a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Synthetic: yes. Other_details: chemically synthesized peptide
Chain: A (121 residues) CATH domain: 1.20.90.10
2g58
Crystal structure of a complex of phospholipase a2 with a de peptide inhibitor dehydro-ile-ala-arg-ser at 0.98 a resolut
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Synthetic: yes. Other_details: chemically synthesized
Chain: A (121 residues) CATH domain: 1.20.90.10
2ghn
Homology model of human group v phospholipase a2
Source: Homo sapiens. Human
Chain: A (118 residues)
2gns
Design of specific peptide inhibitors of phospholipase a2: crystal structure of the complex formed between a group ii phospholipase a2 and a designed pentapeptide ala- leu- val- tyr- lys at 2.3 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Synthetic: yes. Other_details: chmically synthesized
Chain: A (121 residues) CATH domain: 1.20.90.10
2gny
Synovial pla2 strucrue prediction
Source: Homo sapiens. Human
Chain: A (124 residues)
2h4c
Structure of daboiatoxin (heterodimeric pla2 venom)
Source: Daboia russellii siamensis. Organism_taxid: 343250. Strain: siamensis. Secretion: venom. Secretion: venom
Chains: A, B, C, D, E, F, G, H (122 residues) CATH domain: 1.20.90.10
2i0u
Crystal structures of phospholipases a2 from vipera nikolski revealing triton x-100 bound in hydrophobic channel
Source: Vipera nikolskii. Organism_taxid: 110206. Secretion: venom
Chains: E, A (122 residues) CATH domain: 1.20.90.10
2kyt
Solution struture of the h-rev107 n-terminal domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2g16, hrasls3, hrev107. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (125 residues) CATH domain: Unassigned
2not
Notechis ii-5, neurotoxic phospholipase a2 from notechis scutatus scutatus
Source: Notechis scutatus scutatus. Organism_taxid: 70142. Strain: scutatus. Secretion: venom
Chains: A, B (119 residues) CATH domain: 1.20.90.10
2o1n
Crystal structure of a complex of phospholipase a2 with a peptide ala-ile-ala-ser at 2.8 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Synthetic: yes
Chain: A (121 residues) CATH domain: 1.20.90.10
2oli
Crystal structure of the complex formed between a group ii phospholipase a2 and an indole derivative at 2.2 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group IOP is 42.00% similar to enzyme product carboxylate
2oqd
Crystal structure of bthtx-ii
Source: Bothrops jararacussu. Jararacussu. Organism_taxid: 8726. Other_details: gland venom
Chains: A, B (122 residues) CATH domain: 1.20.90.10
2osh
Crystal structure of natratoxin, a snake spla2 that blocks a-type k+ channel
Source: Naja atra. Chinese cobra. Organism_taxid: 8656. Secretion: venom
Chain: A (119 residues) CATH domain: 1.20.90.10
2osn
An alternate description of a crystal structure of phospholipase a2 from bungarus caeruleus
Source: Bungarus caeruleus. Organism_taxid: 132961. Secretion: venom
Chain: A (118 residues) CATH domain: 1.20.90.10
2otf
Crystal structure of the complex formed between phospholipase a2 and atenolol at 1.95 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
2oth
Crystal structure of a ternary complex of phospholipase a2 with indomethacin and nimesulide at 2.9 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group IMN is 45.00% similar to enzyme product carboxylate
2oub
Crystal structure of the complex formed between phospholipase a2 and atenolol at 2.75 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
2oyf
Crystal structure of the complex of phospholipase a2 with indole acetic acid at 1.2 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Secretion: venom
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACY is 60.00% similar to enzyme product carboxylic acid
2pb8
Crystal structure of the complex formed between phospholipase a2 and peptide ala-val-tyr-ser at 2.0 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Synthetic: yes. Other_details: chemically synthesized
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylic acid
2phi
A large conformational change is found in the crystal struct porcine pancreatic phospholipase a2 point mutant f63v
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: pancreas
Chains: A, B (124 residues) CATH domain: 1.20.90.10
2pmj
Crystal structure of the complex formed between phospholipase a2 and 1, 2 benzopyrone at 2.4 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group COU is 42.00% similar to enzyme product carboxylate
2pvt
Crystal structure of a new isoform of phospholipase a2 from russells viper at 2.1 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
2pws
Crystal structure of the complex formed between phospholipase a2 and 2-(4-isobutyl-phenyl)-propionic acid at 2.2 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group IBP is 57.00% similar to enzyme product carboxylate
2pyc
Crystal structure of a monomeric phospholipase a2 from russell's viper at 1.5a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylic acid
2q1p
Crystal structure of phospholipase a2 complex with propanol at 1.5 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella. Other_details: snake venom
Chain: A (121 residues) CATH domain: 1.20.90.10
2qhg
Crystal structure of ecarpholin s (ser49-pla2) complexed with suramin
Source: Echis carinatus. Saw-scaled viper. Other_details: snake venom gland
Chains: A, B, C, D, E, F, G, H (122 residues) CATH domain: 1.20.90.10
2qhw
Crystal structure of a complex of phospholipase a2 with a gramine derivative at 2.2 resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group PZZ is 48.00% similar to enzyme product carboxylate
2qog
Crotoxin b, the basic pla2 from crotalus durissus terrificus.
Source: Crotalus durissus terrificus. Tropical rattlesnake. Organism_taxid: 8732. Strain: terrificus. Other_details: venom glands. Other_details: venom glands
Chains: A, B, C, D (122 residues) CATH domain: 1.20.90.10
2qu9
Crystal structure of the complex of group ii phospholipase a2 with eugenol
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
2que
Saturation of substrate-binding site using two natural ligands: crystal structure of a ternary complex of phospholipase a2 with anisic acid and ajmaline at 2.25 a resolution
Source: Daboia russellii pulchella. Russell's viper. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group AJM is 65.00% similar to enzyme product carboxylate
2qvd
Identification of a potent anti-inflammatory agent from the extract of plant cardiospermun helicacabum: crystal structu complex of phospholipase a2 with benzo(g)-1,3-benzodioxolo( quinolizinium, 5,6-dihydro-9,10-dimethoxy at 1.93 a resolut
Source: Daboia russellii pulchella. Russell's viper. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
2rd4
Design of specific inhibitors of phospholipase a2: crystal structure of the complex of phospholipase a2 with pentapeptide leu-val-phe-phe-ala at 2.9 a resolution
Source: Naja sagittifera. Organism_taxid: 195058. Synthetic: yes. Other_details: the peptide was chemically synthesized
Chains: A, B (119 residues) CATH domain: 1.20.90.10
2wg7
Structure of oryza sativa (rice) pla2
Source: Oryza sativa. Rice. Organism_taxid: 4530. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (121 residues)
2wg8
Structure of oryza sativa (rice) pla2, orthorhombic crystal form
Source: Oryza sativa. Rice. Organism_taxid: 4530. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (108 residues)
2wg9
Structure of oryza sativa (rice) pla2, complex with octanoic acid
Source: Oryza sativa. Rice. Organism_taxid: 4530. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (114 residues)
2wq5
Non-antibiotic properties of tetracyclines: structural basis for inhibition of secretory phospholipase a2.
Source: Naja naja. Indian cobra. Organism_taxid: 35670. Organ: venom sack
Chain: A (119 residues) CATH domain: 1.20.90.10
2zbh
Crystal structure of the complex of phospholipase a2 with bavachalcone from aerva lanata at 2.6 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group BVL is 59.00% similar to enzyme product carboxylate
2zp3
Carboxylic ester hydrolase, single mutant d49n of bovine pancreatic pla2 enzyme
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Strain: pancreas. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
2zp4
Carboxylic ester hydrolase, single mutant h48n of bovine pancreatic pla2 enzyme
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Strain: pancreas. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
2zp5
Carboxylic ester hydrolase, single mutant d49k of bovine pancreatic pla2 enzyme
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Strain: pancreas. Gene: pla2g1b. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (123 residues) CATH domain: 1.20.90.10
3bp2
Role of the n-terminus in the interaction of pancreatic phospholipase a2 with aggregated substrates. Properties and crystal structure of transaminated phospholipase a2
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (123 residues) CATH domain: 1.20.90.10
3cbi
Crystal structure of the ternary complex of phospholipase a2 with ajmaline and anisic acid at 3.1 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228. Strain: pulchella
Chains: A, B, C, D (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group AJM is 65.00% similar to enzyme product carboxylate
3elo
Crystal structure of human pancreatic prophospholipase a2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2g1b. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chain: A (133 residues) CATH domain: 1.20.90.10
3fg5
Crystal structure determination of a ternary complex of phospholipase a2 with a pentapetide flsyk and ajmaline at 2.5 a resolution
Source: Daboia russelli pulchella. Russell's viper. Organism_taxid: 97228. Synthetic: yes. Other_details: synthesized short peptide
Chain: A (121 residues) CATH domain: 1.20.90.10
3fo7
Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase a2 complexed with indomethacin at 1.4 a resolution reveals the presence of the new common ligand binding site
Source: Daboia russelli pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
3fvi
Crystal structure of complex of phospholipase a2 with octyl
Source: Sus scrofa. Pigs,swine,wild boar. Organism_taxid: 9823. Organ: pancreas. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (124 residues) CATH domain: 1.20.90.10
3fvj
Crystal structure of phospholipase a2 1b crystallized in the of octyl sulfate
Source: Sus scrofa. Pigs,swine,wild boar. Organism_taxid: 9823. Expressed in: escherichia coli
Chain: A (124 residues) CATH domain: 1.20.90.10
3g8f
Crystal structure of the complex formed between a group ii phospholipase a2 and designed peptide inhibitor carbobenzox val-ala-arg-ser at 1.2 a resolution
Source: Daboia russellii russellii. Indian russell's viper. Organism_taxid: 31159. Synthetic: yes
Chain: A (121 residues) CATH domain: 1.20.90.10
3g8g
Crystal structure of phospholipase a2 ammodytoxin a from vip ammodytes ammodytes
Source: Vipera ammodytes ammodytes. Western sand viper. Organism_taxid: 8705. Strain: northern balkan. Gene: atxa. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (122 residues) CATH domain: 1.20.90.10
3g8h
Crystal structure of phospholipase a2 ammodytoxin c from vip ammodytes ammodytes
Source: Vipera ammodytes ammodytes. Western sand viper. Organism_taxid: 8705. Strain: northern balkan. Secretion: venom
Chain: A (122 residues) CATH domain: 1.20.90.10
3gci
Crystal structure of the complex formed between a new isofor phospholipase a2 with c-terminal amyloid beta heptapeptide resolution
Source: Naja sagittifera. Andaman cobra. Organism_taxid: 195058. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Other_details: this peptide was chemically synthesized. Thi sequence occurs naturally in humans.
Chain: A (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ALA is 42.86% similar to enzyme product carboxylate
3h1x
Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase a2 complexed with indomethacin at 1.4 a resolution reveals the presence of the new common ligand binding site
Source: Daboia russellii russellii. Indian russell's viper. Organism_taxid: 31159. Strain: viper russells
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group IMN is 45.00% similar to enzyme product carboxylate
3hsw
Crystal structure of porcine pancreatic phospholipase a2 in with 2-methoxycyclohexa-2-5-diene-1,4-dione
Source: Sus scrofa. Pig. Organism_taxid: 9823. Other_details: pancreas
Chain: A (124 residues) CATH domain: 1.20.90.10
3jq5
Phospholipase a2 prevents the aggregation of amyloid beta peptides: crystal structure of the complex of phospholipase a2 with octapeptide fragment of amyloid beta peptide, asp- ala-glu-phe-arg-his-asp-ser at 2 a resolution
Source: Naja sagittifera. Andaman cobra. Organism_taxid: 195058. Synthetic: yes. Other_details: peptide synthesis
Chain: A (119 residues) CATH domain: 1.20.90.10
3jql
Crystal structure of the complex formed between phospholipase a2 and a hexapeptide fragment of amyloid beta peptide, lys-leu-val-phe-phe-ala at 1.2 a resolution
Source: Naja sagittifera. Andaman cobra. Organism_taxid: 195058. Synthetic: yes. Other_details: peptide synthesis
Chain: A (119 residues) CATH domain: 1.20.90.10
3jr8
Crystal structure of bthtx-ii (asp49-pla2 from bothrops jara snake venom) with calcium ions
Source: Bothrops jararacussu. Organism_taxid: 8726. Secretion: venom
Chains: A, B (122 residues) CATH domain: 1.20.90.10
3jti
Crystal structure of the complex formed between phospholipas beta-amyloid fragment, lys-gly-ala-ile-ile-gly-leu-met at 1 resolution
Source: Naja sagittifera. Andaman cobra. Organism_taxid: 195058. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Other_details: this peptide was chemically synthesized.
Chain: A (119 residues) CATH domain: 1.20.90.10
3l30
Crystal structure of porcine pancreatic phospholipase a2 com with dihydroxyberberine
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (124 residues) CATH domain: 1.20.90.10
3l69
Crystal structure of porcine pancreatic phospholipase a2 com with berberine
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (124 residues) CATH domain: 1.20.90.10
3nju
Crystal structure of the complex of group i phospholipase a2 methoxy-benzoicacid at 1.4a resolution
Source: Naja sagittifera. Andaman cobra. Organism_taxid: 195058
Chain: A (119 residues) CATH domain: 1.20.90.10
3o4m
Crystal structure of porcine pancreatic phospholipase a2 in with 1,2-dihydroxybenzene
Source: Sus scrofa. Pig. Organism_taxid: 9823. Tissue: pancreas
Chain: A (124 residues) CATH domain: 1.20.90.10
3osh
Crystal structure of the complex of group 1 phospholipase a2 atropin at 1.5 a resolution
Source: Naja sagittifera. Andaman cobra. Organism_taxid: 195058
Chain: A (119 residues) CATH domain: 1.20.90.10
3p2p
Enhanced activity and altered specificity of phospholipase a2 by deletion of a surface loop
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: pancreas
Chains: A, B (119 residues) CATH domain: 1.20.90.10
3q4y
Crystal structure of group i phospholipase a2 at 2.3 a resol 40% ethanol revealed the critical elements of hydrophobicit substrate-binding site
Source: Naja sagittifera. Andaman cobra. Organism_taxid: 195058
Chain: A (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group EOH is 40.00% similar to enzyme product carboxylate
3qlm
Crystal structure of porcine pancreatic phospholipase a2 in with n-hexadecanoic acid
Source: Sus scrofa. Pigs. Organism_taxid: 9823. Tissue: pancreas
Chain: A (124 residues) CATH domain: 1.20.90.10
3r0l
Crystal structure of crotoxin
Source: Crotalus durissus terrificus. South american rattlesnake,cascabel. Organism_taxid: 8732. Other_details: from south american rattlesnake venom. Other_details: from south american rattlesnake venom
Chain: D (122 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylic
3tt5
Crystal structure of porcine pancreatic phospholipase a2 com with berberine
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (124 residues) CATH domain: 1.20.90.10
3u8b
Functionally selective inhibition of group iia phospholipase reveals a role for vimentin in regulating arachidonic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2g2a, pla2b, pla2l, rasf-a. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chain: A (124 residues) CATH domain: 1.20.90.10
3u8d
Functionally selective inhibition of group iia phospholipase reveals a role for vimentin in regulating arachidonic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2g2a, pla2b, pla2l, rasf-a. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (124 residues) CATH domain: 1.20.90.10
3u8h
Functionally selective inhibition of group iia phospholipase reveals a role for vimentin in regulating arachidonic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2g2a, pla2b, pla2l, rasf-a. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (124 residues) CATH domain: 1.20.90.10
3u8i
Functionally selective inhibition of group iia phospholipase reveals a role for vimentin in regulating arachidonic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2g2a, pla2b, pla2l, rasf-a. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chains: A, B (124 residues) CATH domain: 1.20.90.10
3v9m
Phospholipase acii4 from australian king brown snake
Source: Pseudechis australis. King brown snake. Organism_taxid: 8670
Chains: A, B (118 residues) CATH domain: 1.20.90.10
4bp2
Crystallographic refinement of bovine pro-phospholipase a2 at 1.6 angstroms resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913
Chain: A (117 residues) CATH domain: 1.20.90.10
4dbk
Crystal structure of porcine pancreatic phospholipase a2 com with berberine
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (124 residues) CATH domain: 1.20.90.10
4dot
Crystal structure of human hrasls3.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2g16, hrasls3, hrev107. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: Unassigned
4e4c
Crystal structure of notexin at 1.8 a resolution
Source: Notechis scutatus scutatus. Mainland tiger snake. Organism_taxid: 70142
Chain: A (118 residues) CATH domain: 1.20.90.10
4eix
Structural studies of the ternary complex of phaspholipase a nimesulide and indomethacin
Source: Daboia russellii pulchella. Russell's viper. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
4fa0
Crystal structure of human adpla to 2.65 a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pla2g16, hrasls3, hrev107. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (102 residues) CATH domain: Unassigned
4fga
Design of peptide inhibitors of group ii phospholipase a2: c structure of the complex of phospholipsae a2 with a designe tripeptide, ala- tyr- lys at 2.3 a resolution
Source: Daboia russellii pulchella. Russell's viper. Organism_taxid: 97228. Synthetic: yes. Other_details: synthetic peptide
Chain: A (121 residues) CATH domain: 1.20.90.10
4g5i
Crystal structure of porcine pancreatic pla2 in complex with
Source: Sus scrofa. Pigs. Organism_taxid: 9823
Chain: A (124 residues) CATH domain: 1.20.90.10
4gfy
Design of peptide inhibitors of phospholipase a2: crystal st phospholipase a2 complexed with a designed tetrapeptide val ala - lys at 2.7 a resolution
Source: Daboia russellii pulchella. Russell's viper. Organism_taxid: 97228. Synthetic: yes. Other_details: synthetic peptide
Chain: A (121 residues) CATH domain: 1.20.90.10
4gld
Crystal structure of the complex of type ii phospholipase a2 designed peptide inhibitor phe - leu - ala - tyr - lys at 1 resolution
Source: Daboia russellii pulchella. Russell's viper. Organism_taxid: 97228. Synthetic: yes. Other_details: synthetic peptide
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylate
4h0q
Crystal structure of a acidic pla2 from trimeresurus stejneg
Source: Viridovipera stejnegeri. Chinese green tree viper. Organism_taxid: 39682
Chains: A, B (121 residues) CATH domain: 1.20.90.10
4hg9
Crystal structure of ahv_bpa, a basic pla2 from agkistrodon pallas venom
Source: Gloydius halys. Chinese water moccasin. Organism_taxid: 8714
Chains: A, B, C, D (122 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group G3P is 52.63% similar to enzyme product 1-acyl-sn-glycero-3-phosphocholine
4hmb
Crystal structure of the complex of group ii phospholipase a 3-{3-[(dimethylamino)methyl]-1h-indol-7-yl}propan-1-ol at 2 resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
4o1y
Crystal structure of porcine pancreatic phospholipase a2 in with 1-naphthaleneacetic acid
Source: Sus scrofa. Pigs,swine,wild boar. Organism_taxid: 9823. Other_details: pancreas
Chain: A (124 residues) CATH domain: 1.20.90.10
4p2p
An independent crystallographic refinement of porcine phosph at 2.4 angstroms resolution
Source: Sus scrofa. Pig. Organism_taxid: 9823
Chain: A (124 residues) CATH domain: 1.20.90.10
4qem
Crystal structure of the complex of phospholipase a2 with p- acid at 1.2 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
4qer
Crystal structure of the complex of phospholipase a2 with re at 1.20 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
4qf7
Crystal structure of the complex of phospholipase a2 with corticosterone at 1.48 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
4qf8
Crystal structure of the complex of phospholipase a2 with sp at 1.65 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
4qgd
Crystal structure of the complex of phospholipase a2 with gr derivative at 1.80 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
4qmc
Crystal structure of complex formed between phospholipase a2 biotin-sulfoxide at 1.09 a resolution
Source: Daboia russellii pulchella. Organism_taxid: 97228
Chain: A (121 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group ACT is 60.00% similar to enzyme product carboxylate
5p2p
X-ray structure of phospholipase a2 complexed with a substrate-derived inhibitor
Source: Sus scrofa. Pig. Organism_taxid: 9823. Organ: pancreas
Chains: A, B (119 residues) CATH domain: 1.20.90.10
Bound ligand:   Het Group DHG is 45.00% similar to enzyme product carboxylate