_EC 2.7.8.7 Holo-[acyl-carrier-protein] synthase. 28 PDB entries  
EC 2.-.-.- Transferases. [19,180 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [11,698 PDB entries]
EC 2.7.8.- Transferases for other substituted phosphate groups. [38 PDB entries]
EC 2.7.8.7 Holo-[acyl-carrier-protein] synthase. [28 PDB entries]    
1f7l

Reaction: CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].
 

CoA-(4'-phosphopantetheine)
+ apo-[acyl-carrier-protein]
=
adenosine 3',5'-bisphosphate
+
holo-[acyl-carrier-protein]
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 4'-phosphopantetheinyl transferase. Acps. Acyl carrier protein holoprotein (holo-ACP) synthetase. Acyl carrier protein synthase. Acyl carrier protein synthetase. Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase. Holo-ACP synthase. Holo-ACP synthetase. Holosynthase.
Cofactor(s): Mg(2+).
Comments: All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post-translational modification of their constituent acyl-carrier-protein (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4'-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each Acp domain. The enzyme from human can activate both the Acp domain of the human cytosolic multifunctional fatty acid synthase and that associated
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There are 28 PDB entries in enzyme class E.C.2.7.8.7

  PDB code Protein
1f7l
Holo-(acyl carrier protein) synthase in complex with coenzym 1.5a
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (118 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA is 56.25% similar to enzyme product Adenosine
1f7t
Holo-(acyl carrier protein) synthase at 1.8a
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (119 residues) CATH domain: 3.90.470.20
1f80
Holo-(acyl carrier protein) synthase in complex with holo- (acyl carrier protein)
Source: Bacillus subtilis. Organism_taxid: 1423. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (118 residues) CATH domain: 3.90.470.20
1fte
Crystal structure of streptococcus pneumoniae acyl carrier protein synthase (native 1)
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (116 residues) CATH domain: 3.90.470.20
1ftf
Crystal structure of streptococcus pneumoniae acyl carrier protein synthase (native 2)
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (116 residues) CATH domain: 3.90.470.20
1fth
Crystal structure of streptococcus pneumoniae acyl carrier protein synthase (3'5'-adp complex)
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (117 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group A3P corresponds to enzyme product Adenosine 3',5'-bisphosphate
1lrf
Theoretical model of holo-[acyl-carrier protein] synthase- escherichia coli o157:h7
Source: Escherichia coli. Bacteria. Other_details: cytoplasmic
Chain: A (125 residues)
1nnz
Docking model for mat and acp
Source: Streptomyces coelicolor a3. 2. Streptomyces coelicolor. Gene: sco5089 or scbac28g1.15
Chain: B (86 residues)
2jbz
Crystal structure of the streptomyces coelicolor holo- [acyl-carrier-protein] synthase (acps) in complex with coenzyme a at 1.6 a
Source: Streptomyces coelicolor. Organism_taxid: 1902. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (124 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA is 56.25% similar to enzyme product Adenosine
2jca
Crystal structure of the streptomyces coelicolor holo- [acyl-carrier-protein] synthase (acps) at 2 a.
Source: Streptomyces coelicolor. Organism_taxid: 1902. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (123 residues) CATH domain: 3.90.470.20
2wdo
Crystal structure of the s. Coelicolor acps in complex with acetyl-coa at 1.5 a
Source: Streptomyces coelicolor. Organism_taxid: 1902. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (123 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group ACO is 52.94% similar to enzyme product Adenosine
2wds
Crystal structure of the streptomyces coelicolor h110a acps mutant in complex with cofactor coa at 1.3 a
Source: Streptomyces coelicolor. Organism_taxid: 1902. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (123 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA is 56.25% similar to enzyme product Adenosine
2wdy
Crystal structure of the streptomyces coelicolor d111a acps mutant in complex with cofactor coa at 1.4 a
Source: Streptomyces coelicolor. Organism_taxid: 1902. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (123 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA is 56.25% similar to enzyme product Adenosine
3f09
1.82 angstrom resolution crystal structure of holo-(acyl-car protein) synthase (acps) from staphylococcus aureus
Source: Staphylococcus aureus subsp. Aureus co organism_taxid: 93062. Strain: staphylococcus aureus subsp. Aureus col. Gene: acps, sacol2061. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (122 residues) CATH domain: 3.90.470.20
3gwm
Crystal structure of the holo-[acyl-carrier-protein] synthase (acps) from mycobacterium smegmatis
Source: Mycobacterium smegmatis. Organism_taxid: 246196. Strain: mc2 155
Chain: A (129 residues) CATH domain: 3.90.470.20
3h7q
Crystal structure of the holo-[acyl-carrier-protein] synthase (acps) from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: rv2523c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (120 residues) CATH domain: 3.90.470.20
3h88
Crystal structure of 4'-phosphopantetheinyl transferase acps vibrio cholerae o1 biovar eltor
Source: Vibrio cholerae. Organism_taxid: 666. Strain: n16961. Gene: acps, vc_2457. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (126 residues) CATH domain: 3.90.470.20
3hqj
Structure-function analysis of mycobacterium tuberculosis acyl carrier protein synthase (acps).
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: acps, rv2523c, mt2599, mtv009.08c. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (113 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA corresponds to enzyme product Adenosine 3',5'-bisphosphate
3hyk
2.31 angstrom resolution crystal structure of a holo-(acyl-c protein) synthase from bacillus anthracis str. Ames in comp coa (3',5'-adp)
Source: Bacillus anthracis. Anthrax,anthrax bacterium. Organism_taxid: 1392. Strain: bacillus anthracis str. Ames. Gene: acps, ba_0250, gbaa_0250, bas0236. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (117 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group A3P corresponds to enzyme product Adenosine
3ne1
Mycobacterium tuberculosis acyl carrier protein synthase in with sulfate ion
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: acps, mt2599, mtv009.08c, mycobacterium tuberculosis, expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (129 residues) CATH domain: 3.90.470.20
3ne3
Mycobacterium tuberculosis acyl carrier protein synthase apo
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: acps, mt2599, mtv009.08c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: B (129 residues) CATH domain: 3.90.470.20
3ne9
Chronobacterium ammoiniagenes apo-acps strucutre
Source: Corynebacterium ammoniagenes. Brevibacterium ammoniagenes. Organism_taxid: 1697. Gene: acps, ppt1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (138 residues) CATH domain: 3.90.470.20
3nfd
Chronobacterium ammoniagenes acps-coa complex
Source: Corynebacterium ammoniagenes. Brevibacterium ammoniagenes. Organism_taxid: 1697. Gene: ppt1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (136 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA corresponds to enzyme product Adenosine
3ota
Crystal structure of 4'-phosphopantetheinyl transferase acps vibrio cholerae o1 biovar eltor
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: acps, vc_2457. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (126 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA is 56.00% similar to enzyme product Adenosine 3',5'-bisphosphate
3qmn
Crystal structure of 4'-phosphopantetheinyl transferase acps vibrio cholerae o1 biovar eltor
Source: Vibrio cholerae o1 biovar el tor. Organism_taxid: 243277. Strain: n16961. Gene: acps, vc_2457. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (126 residues) CATH domain: 3.90.470.20
Bound ligand:   Het Group COA is 56.25% similar to enzyme product Adenosine
4dxe
2.52 angstrom resolution crystal structure of the acyl-carri synthase (acps)-acyl carrier protein (acp) protein-protein from staphylococcus aureus subsp. Aureus col
Source: Staphylococcus aureus. Organism_taxid: 93062. Strain: staphylococcus aureus subsp. Aureus col. Gene: acps, sacol2061. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: acpp, apcp, sacol1247.
Chains: A, B, C, D, E, F (113 residues) CATH domain: 3.90.470.20
4hc6
Mycobacterium tuberculosis rv2523ce77a x-ray structure solve angstrom resolution
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: acps, mt2599, mtv009.08c, rv2523c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (129 residues) CATH domain: 3.90.470.20
4jm7
1.82 angstrom resolution crystal structure of holo-(acyl-car protein) synthase (acps) from staphylococcus aureus
Source: Staphylococcus aureus. Organism_taxid: 93062. Strain: col. Gene: acps, sacol2061. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (122 residues) CATH domain: 3.90.470.20