_EC 2.7.7.3 Pantetheine-phosphate adenylyltransferase. 34 PDB entries  
EC 2.-.-.- Transferases. [18,993 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [11,579 PDB entries]
EC 2.7.7.- Nucleotidyltransferases. [4,701 PDB entries]
EC 2.7.7.3 Pantetheine-phosphate adenylyltransferase. [34 PDB entries]    
1b6t

Pathway: Coenzyme A Biosynthesis (late stages)
Reaction: Atp + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.
 


ATP
+
pantetheine 4'-phosphate
=
diphosphate
+ 3'-dephospho-CoA
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 3'-dephospho-CoA pyrophosphorylase. Dephospho-CoA diphosphorylase. Dephospho-CoA pyrophosphorylase. Dephospho-coenzyme A pyrophosphorylase. Phosphopantetheine adenylyltransferase. Ppat.
Comments: The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of Ec 2.3.1.157.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 34 PDB entries in enzyme class E.C.2.7.7.3

  PDB code Protein
1b6t
Phosphopantetheine adenylyltransferase in complex with 3'- dephospho-coa from escherichia coli
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COD is 56.00% similar to enzyme reactant ATP
1gn8
Phosphopantetheine adenylyltransferase in complex with mn2+ atp from escherichia coli
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (159 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1h1t
Phosphopantetheine adenylyltransferase in complex with coenzyme a from escherichia coli
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (158 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COA is 51.00% similar to enzyme reactant ATP
1o6b
Crystal structure of phosphopantetheine adenylyltransferase
Source: Bacillus subtilis. Organism_taxid: 1423. Gene: coad, bsu15020. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (163 residues) CATH domain: 3.40.50.620
Bound ligands:   Het Group ADP is 87.10% similar to enzyme reactant ATP
  Het Group PO4 is 55.56% similar to enzyme product diphosphate
1od6
The crystal structure of phosphopantetheine adenylyltransferase from thermus thermophilus in complex with 4'-phosphopantetheine
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (155 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group PNS corresponds to enzyme reactant pantetheine 4'-phosphate
1qjc
Phosphopantetheine adenylytransferase from escherichia coli in complex with 4'-phosphopantetheine
Source: Escherichia coli. Organism_taxid: 562
Chains: A, B (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group PNS corresponds to enzyme reactant pantetheine 4'-phosphate
1tfu
Phosphopantetheine adenylyltransferase from mycobacterium tu
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e, mb29 expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 (de3).
Chain: A (157 residues) CATH domain: 3.40.50.620
1vlh
Crystal structure of phosphopantetheine adenylyltransferase from thermotoga maritima at 2.20 a resolution
Source: Thermotoga maritima. Organism_taxid: 2336. Gene: coad, kdtb, tm0741. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group PNS corresponds to enzyme reactant pantetheine
2f6r
Crystal structure of bifunctional coenzyme a synthase (coa s (18044849) from mus musculus at 1.70 a resolution
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: coasy, ukr1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (230 residues) CATH domain: 3.40.50.300
Bound ligand:   Het Group ACO is 49.09% similar to enzyme reactant ATP
3do8
The crystal structure of the protein with unknown function from archaeoglobus fulgidus
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Strain: dsm 4304. Gene: coad, af_2206. Expressed in: escherichia coli.
Chains: A, B (135 residues) CATH domain: 3.40.50.620
3f3m
Six crystal structures of two phosphopantetheine adenylyltra reveal an alternative ligand binding mode and an associated structural change
Source: Staphylococcus aureus. Organism_taxid: 1280. Gene: coad. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (155 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group PPS is 58.97% similar to enzyme reactant ATP
3ikz
Crystal structure of phosphopantetheine adenylyltransferase burkholderia pseudomallei
Source: Burkholderia pseudomallei 1710b. Organism_taxid: 320372. Strain: 1710b. Gene: coad, burps1710b_0748. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COD is 56.00% similar to enzyme reactant ATP
3l92
Phosphopantetheine adenylyltransferase from yersinia pestis with coenzyme a.
Source: Yersinia pestis. Organism_taxid: 214092. Strain: co92. Gene: coad, kdtb, y0088, ypo0053, yp_0054. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COA is 51.92% similar to enzyme reactant ATP
3l93
Phosphopantetheine adenylyltransferase from yersinia pestis.
Source: Yersinia pestis. Organism_taxid: 214092. Strain: co92. Gene: coad, kdtb, y0088, ypo0053, yp_0054. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (161 residues) CATH domain: 3.40.50.620
3lcj
Phosphopantetheine adenylyltransferase from mycobacterium tu complexed with coa
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COA is 51.92% similar to enzyme reactant ATP
3nba
Phosphopantetheine adenylyltranferase from mycobacterium tub in complex with adenosine-5'-[(alpha,beta)-methyleno]tripho (ampcpp)
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, mt3043, mtcy349.22, rv2965c, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (156 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group APC is 55.00% similar to enzyme reactant ATP
3nbk
Phosphopantetheine adenylyltransferase from mycobacterium tu in complex with 4'-phosphopantetheine
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, mt3043, mtcy349.22, rv2965c, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (158 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group PNS corresponds to enzyme reactant pantetheine 4'-phosphate
3nd5
Crystal structure of phosphopantetheine adenylyltransferase from enterococcus faecalis
Source: Enterococcus faecalis. Streptococcus faecalis. Organism_taxid: 1351. Gene: coad. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (152 residues) CATH domain: 3.40.50.620
3nd6
Crystal structure of phosphopantetheine adenylyltransferase complex with atp from enterococcus faecalis
Source: Enterococcus faecalis. Streptococcus faecalis. Organism_taxid: 1351. Gene: coad. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (152 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3nd7
Crystal structure of phosphopantetheine adenylyltransferase enterococcus faecalis in the ligand-unbound state and in co atp and pantetheine
Source: Enterococcus faecalis. Streptococcus faecalis. Organism_taxid: 1351. Gene: coad. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (152 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group PNY is 81.82% similar to enzyme reactant pantetheine
3nv7
Crystal structure of h.Pylori phosphopantetheine adenylyltra mutant i4v/n76y
Source: Helicobacter pylori. Organism_taxid: 85962. Strain: 26695. Gene: coad, kdtb, hp_1475. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (155 residues) CATH domain: 3.40.50.620
3otw
Structural and functional studies of helicobacter pylori wil mutated proteins phosphopantetheine adenylyltransferase
Source: Helicobacter pylori. Organism_taxid: 85962. Strain: 26695. Gene: coad, kdtb, hp_1475. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COA is 51.92% similar to enzyme reactant ATP
3pnb
Phosphopantetheine adenylyltransferase from mycobacterium tu in complex with coenzyme a
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COA is 51.92% similar to enzyme reactant ATP
3pxu
Crystal structure of phosphopantetheine adenylyltransferase burkholderia pseudomallei bound to dephospho-coenzyme a
Source: Burkholderia pseudomallei. Organism_taxid: 320372. Strain: 1710b. Gene: burps1710b_0748, coad, coad burps1710b_0748. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (159 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COD is 56.25% similar to enzyme reactant ATP
3rba
Phosphopantetheine adenylyltransferase from mycobacterium tu complexed with dpcoa
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COD is 56.25% similar to enzyme reactant ATP
3rff
Phosphopantetheine adenylyltransferase from mycobacterium tu (1.76 a resolution)
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (157 residues) CATH domain: 3.40.50.620
3rhs
Phosphopantetheine adenylyltransferase from mycobacterium tu complexed with coa
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group COA is 51.92% similar to enzyme reactant ATP
3uc5
Phosphopantetheine adenylyltransferase from mycobacterium tu complexed with atp
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (157 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4e1a
Phosphopantetheine adenylyltransferase from mycobacterium tu at 1.62a resolution
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (157 residues) CATH domain: 3.40.50.620
4f3r
Structure of phosphopantetheine adenylyltransferase (cbu_028 coxiella burnetii
Source: Coxiella burnetii. Organism_taxid: 227377. Strain: rsa 493 nine mile phase i. Gene: cbu_0288, coad. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (146 residues) CATH domain: 3.40.50.620
4nah
Inhibitors of 4-phosphopanthetheine adenylyltransferase (ppa
Source: Staphylococcus aureus. Organism_taxid: 196620. Strain: mw2. Gene: coad, mw1007. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (159 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group AGS is 93.75% similar to enzyme reactant ATP
4nat
Inhibitors of 4-phosphopanthetheine adenylyltransferase
Source: Staphylococcus aureus. Organism_taxid: 196620. Strain: mw2. Gene: coad, mw1007. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (153 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group ADP is 87.10% similar to enzyme reactant ATP
4nau
S. Aureus coad with inhibitor
Source: Staphylococcus aureus. Organism_taxid: 196620. Strain: mw2. Gene: coad, mw1007. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (159 residues) CATH domain: 3.40.50.620
Bound ligand:   Het Group AGS is 93.75% similar to enzyme reactant ATP
4r0n
Hexagonal form of phosphopantetheine adenylyltransferase fro mycobacterium tuberculosis
Source: Mycobacterium tuberculosis bt1. Organism_taxid: 1010836. Gene: coad, hkbt1_3114. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, C, E, G, I, K (156 residues) CATH domain: 3.40.50.620