_EC 2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. 56 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,910 PDB entries]
EC 2.7.6.- Diphosphotransferases. [83 PDB entries]
EC 2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase. [56 PDB entries]    
1cbk

Pathway: Folate Biosynthesis (late stages)
Reaction: Atp + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = amp + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
 


ATP
+
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
=
AMP
+ (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. 6-hydroxymethyl-7,8-dihydropterin diphosphokinase. 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. 7,8-dihydro-6-hydroxymethylpterin diphosphokinase. 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 56 PDB entries in enzyme class E.C.2.7.6.3

  PDB code Protein
1cbk
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase from haemophilus influenzae
Source: Haemophilus influenzae. Organism_taxid: 727. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (160 residues) CATH domain: 3.30.70.560
Bound ligand:   Het Group ROI is 70.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1dy3
Ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from escherichia coli with atp and a substrate analogue.
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group 87Y is 60.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1eq0
Solution structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with mgamppcp
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
1eqm
Crystal structure of binary complex of 6-hydroxymethyl-7,8- dihydropterin pyrophosphokinase with adenosine-5'- diphosphate
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligand:   Het Group ADP is 87.00% similar to enzyme reactant ATP
1eqo
Crystal structure of a ternary complex of 6-hydroxymethyl-7, 8-dihydropterin pyrophosphokinase from e. Coli with mgampcpp and 6-hydroxymethyl-7,8-dihydropterin at 1.25 angstrom resolution
Source: Escherichia coli. Bacteria. Expressed in: escherichia coli.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group APC is 55.00% similar to enzyme reactant ATP
  Het Group HHP is 56.00% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
1ex8
Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with hp4a, the two-substrate- mimicking inhibitor
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligand:   Het Group A4P is 64.00% similar to enzyme reactant ATP
1f9h
Crystal structure of the ternary complex of e. Coli hppk(r92a) with mgampcpp and 6-hydroxymethyl-7,8- dihydropterin at 1.50 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group PH2 corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
1f9y
Crystal structure of the ternary complex of e. Coli hppk with mgampcpp and oxidation products of 6-hydroxymethyl-7, 8-dihydropterin
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group APC is 68.00% similar to enzyme product AMP
  Het Group HHR is 56.00% similar to enzyme product 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
1g4c
Crystal structure of a complex of hppk(r92a) from e.Coli with mg2+ at 1.65 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (158 residues) CATH domain: 3.30.70.560
1hka
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Source: Escherichia coli. Organism_taxid: 562. Gene: folk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (158 residues) CATH domain: 3.30.70.560
1hq2
Crystal structure of a ternary complex of e.Coli hppk(r82a) with mgampcpp and 6-hydroxymethyl-7,8-dihydropterin at 1.25 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group PH2 corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
1im6
Crystal structure of unligated hppk(r82a) from e.Coli at 1.74 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
1kbr
Crystal structure of unligated hppk(r92a) from e.Coli at 1.55 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
1q0n
Crystal structure of a ternary complex of 6-hydroxymethyl-7, 8-dihydropterin pyrophosphokinase from e. Coli with mgampcpp and 6-hydroxymethyl-7,8-dihydropterin at 1.25 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Gene: folk or b0142. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group PH2 corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
1rao
Crystal structure of a ternary complex of e. Coli hppk with amp and 6-hydroxymethylpterin-diphosphate at 1.56 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Gene: folk, b0142. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group HH2 is 63.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group AMP corresponds to enzyme product AMP
1rb0
Crystal structure of a binary complex of e. Coli hppk with 6-hydroxymethylpterin-diphosphate at 1.35 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Gene: folk, b0142. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligand:   Het Group HH2 is 63.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
1rtz
Crystal structure of e.Coli apo-hppk(v83g/del84-89) at 1.33 resolution
Source: Escherichia coli. Organism_taxid: 562. Gene: folk, b0142. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (152 residues) CATH domain: 3.30.70.560
1ru1
Crystal structure of a ternary complex of e. Coli hppk(v83g/del84-89) with mgampcpp and 6-hydroxymethyl-7,8- dihydropterin at 1.40 angstrom resolution (monoclinic form)
Source: Escherichia coli. Organism_taxid: 562. Gene: folk, b0142. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (143 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group PH2 corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
1ru2
Crystal structure of a ternary complex of e.Coli hppk(v83g/del84-89) with mgampcpp and 6- hydroxymethylpterin at 1.48 angstrom resolution (orthorhombic form)
Source: Escherichia coli. Organism_taxid: 562. Gene: folk, b0142. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (146 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group HHR corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
1tmj
Crystal structure of e.Coli apo-hppk(w89a) at 1.45 angstrom resolution
Source: Escherichia coli. Organism_taxid: 562. Gene: folk, b0142. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
1tmm
Crystal structure of ternary complex of e.Coli hppk(w89a) wi mgampcpp and 6-hydroxymethylpterin
Source: Escherichia coli. Organism_taxid: 562. Gene: folk, b0142. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group HHR corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
2bmb
X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from saccharomyces cerevisiae
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (513 residues) CATH domains: 3.30.70.560 3.20.20.20
Bound ligand:   Het Group PMM is 77.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
2cg8
The bifunctional dihydroneopterin aldolase 6-hydroxymethyl- 7,8-dihydropterin synthase from streptococcus pneumoniae
Source: Streptococcus pneumoniae. Organism_taxid: 1313. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (241 residues) CATH domains: 3.30.1130.10 3.30.70.560
2f63
Solution structure of hppk in complex with inhibitor analogs ampcpp and hp-1
Source: Escherichia coli. Organism_taxid: 562. Gene: folk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
2f65
Solution structure of hppk in complex with inhibitor analog ampcpp
Source: Escherichia coli. Organism_taxid: 562. Gene: folk. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
2qx0
Crystal structure of yersinia pestis hppk (ternary complex)
Source: Yersinia pestis. Organism_taxid: 632. Strain: hamap proteome. Gene: folk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (159 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group PH2 corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
3h4a
Crystal structure of e. Coli hppk complexed with mgampcpp and oxidation products of 6-hydroxymethyl-7,8-dihydropterin
Source: Escherichia coli k-12. Organism_taxid: 83333. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3hcx
Crystal structure of e. Coli hppk(n10a)
Source: Escherichia coli k-12. Organism_taxid: 83333. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3hd1
Crystal structure of e. Coli hppk(n10a) in complex with mgam
Source: Escherichia coli k-12. Organism_taxid: 83333. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligand:   Het Group APC is 68.00% similar to enzyme product AMP
3hd2
Crystal structure of e. Coli hppk(q50a) in complex with mgam pterin
Source: Escherichia coli k-12. Organism_taxid: 83333. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group PE0 is 85.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
3hsd
Crystal structure of e. Coli hppk(y53a)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k 12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (158 residues) CATH domain: 3.30.70.560
3hsg
Crystal structure of e. Coli hppk(y53a) in complex with mgam
Source: Escherichia coli. Organism_taxid: 83333. Strain: k 12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligand:   Het Group APC is 68.00% similar to enzyme product AMP
3hsj
Crystal structure of e. Coli hppk(n55a)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k 12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3hsz
Crystal structure of e. Coli hppk(f123a)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k 12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3ht0
Crystal structure of e. Coli hppk(f123a) in complex with mga
Source: Escherichia coli. Organism_taxid: 83333. Strain: k 12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligand:   Het Group APC is 68.00% similar to enzyme product AMP
3ili
Crystal structure of e. Coli hppk(d95a)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3ilj
Crystal structure of e. Coli hppk(d95a) in complex with mgam
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligand:   Het Group APC is 68.00% similar to enzyme product AMP
3ill
Crystal structure of e. Coli hppk(d97a)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3ilo
Crystal structure of e. Coli hppk(d97a) in complex with mgam 6-hydroxymethyl-7,8-dihydropterin
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group PH2 corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
3ip0
Crystal structure of e. Coli hppk in complx with mgampcpp and 6-hydroxymethylpterin/6-carboxypterin
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group HHR corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
3kue
Crystal structure of e. Coli hppk(e77a)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3kug
Crystal structure of e. Coli hppk(h115a)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3kuh
Crystal structure of e. Coli hppk(h115a) in complex with amp
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group PH2 corresponds to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.00% similar to enzyme product AMP
3ud5
Crystal structure of e. Coli hppk in complex with bisubstrat inhibitor j1a
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (158 residues) CATH domain: 3.30.70.560
3ude
Crystal structure of e. Coli hppk in complex with bisubstrat inhibitor j1b
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (154 residues) CATH domain: 3.30.70.560
3udv
Crystal structure of e. Coli hppk in complex with bisubstrat inhibitor j1c
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (154 residues) CATH domain: 3.30.70.560
4f7v
Crystal structure of e. Coli hppk in complex with bisubstrat inhibitor j1d (hp26)
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: b0142, foik, folk, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (158 residues) CATH domain: 3.30.70.560
4m5g
The identification, analysis and structure-based development inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophospho
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: folk, b0142, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group YH1 is 45.83% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
4m5h
The identification, analysis and structure-based development inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophospho
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: folk, b0142, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group YH2 is 45.83% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
4m5i
The identification, analysis and structure-based development inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophospho
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: folk, b0142, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group YH6 is 44.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
4m5j
The identification, analysis and structure-based development inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophospho
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: folk, b0142, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (157 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group YH5 is 42.31% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
4m5k
The identification, analysis and structure-based development inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophospho
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: folk, b0142, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group YH3 is 44.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
4m5l
The identification, analysis and structure-based development inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophospho
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: folk, b0142, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group YH4 is 44.00% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
4m5m
The identification, analysis and structure-based development inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophospho
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: folk, b0142, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (159 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group DX4 is 66.67% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
4m5n
The identification, analysis and structure-based development inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophospho
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Gene: folk, b0142, jw0138. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (160 residues) CATH domain: 3.30.70.560
Bound ligands:   Het Group YH7 is 66.67% similar to enzyme reactant 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
  Het Group APC is 68.75% similar to enzyme product AMP
4pzv
Crystal structure of francisella tularensis hppk-dhps in com bisubstrate analog hppk inhibitor j1d
Source: Francisella tularensis subsp. Tularens organism_taxid: 177416. Strain: schu s4 / schu 4. Gene: foik, folk, ftt_0942c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (413 residues) CATH domain: 3.30.70.560