_EC 2.7.6.2 Thiamine diphosphokinase. 7 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,916 PDB entries]
EC 2.7.6.- Diphosphotransferases. [83 PDB entries]
EC 2.7.6.2 Thiamine diphosphokinase. [7 PDB entries]    
1ig0

Reaction: Atp + thiamine = amp + thiamine diphosphate.
 


ATP
+
thiamine
=
AMP
+
thiamine diphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Thiamine kinase. Thiamine pyrophosphokinase.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 7 PDB entries in enzyme class E.C.2.7.6.2

  PDB code Protein
1ig0
Crystal structure of yeast thiamin pyrophosphokinase
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: thi80. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (317 residues) CATH domains: 3.40.50.10240 2.60.120.320
Bound ligand:   Het Group VIB corresponds to enzyme reactant Thiamine
1ig3
Mouse thiamin pyrophosphokinase complexed with thiamin
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (254 residues) CATH domains: 2.60.120.320 3.40.50.10240
Bound ligand:   Het Group VIB corresponds to enzyme reactant Thiamine
1oly
Human thiamin pyrophosphokinase / pp20
Source: Homo sapiens. Human. Tissue: placenta
Chains: A, B (243 residues)
Bound ligand:   Het Group VIB is 40.00% similar to enzyme reactant ATP
2f17
Mouse thiamin pyrophosphokinase in a ternary complex with pyrithiamin pyrophosphate and amp at 2.5 angstrom
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: tpk1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (255 residues) CATH domains: 2.60.120.320 3.40.50.10240
Bound ligands:   Het Group AMP corresponds to enzyme product AMP
  Het Group PYI is 82.00% similar to enzyme product Thiamine diphosphate
3cq9
Crystal structure of the lp_1622 protein from lactobacillus plantarum. Northeast structural genomics consortium target lpr114
Source: Lactobacillus plantarum wcfs1. Organism_taxid: 220668. Strain: wcfs1 / ncimb 8826. Atcc: baa-793. Gene: lp_1622. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (202 residues) CATH domain: Unassigned
3lm8
Crystal structure of thiamine pyrophosphokinase from bacillus subtilis, northeast structural genomics consortium target sr677
Source: Bacillus subtilis. Organism_taxid: 1423. Gene: bsu15800, thin, ylos. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (214 residues)
Bound ligand:   Het Group VIB corresponds to enzyme reactant Thiamine
3s4y
Crystal structure of human thiamin pyrophosphokinase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tpk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (224 residues) CATH domain: Unassigned