_EC 2.7.4.22 Ump kinase. 22 PDB entries  
EC 2.-.-.- Transferases. [17,766 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,813 PDB entries]
EC 2.7.4.- Phosphotransferases with a phosphate group as acceptor. [413 PDB entries]
EC 2.7.4.22 Ump kinase. [22 PDB entries]    
1ybd

Reaction: Atp + ump = adp + udp.
 


ATP
+
UMP
=
ADP
+
UDP
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): UMP-kinase. Umpk. Uridine monophosphate kinase. Uridylate kinase.
Comments: Strictly specific for Ump as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme Ec 2.7.4.14 for the same purpose. Subject of feedback regulation, being inhibited by Utp and activated by Gtp.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 22 PDB entries in enzyme class E.C.2.7.4.22

  PDB code Protein
1ybd
Crystal structure analysis of uridylate kinase from neisseri meningitidis
Source: Neisseria meningitidis. Organism_taxid: 487. Gene: pyrh. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C (236 residues) CATH domain: 3.40.1160.10
1z9d
Crystal structure of a putative uridylate kinase (ump-kinase streptococcus pyogenes
Source: Streptococcus pyogenes. Organism_taxid: 1314. Gene: pyrh. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (238 residues) CATH domain: 3.40.1160.10
2a1f
Crystal structure of uridylate kinase
Source: Haemophilus influenzae. Organism_taxid: 727. Gene: pyrh, smba. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (232 residues) CATH domain: 3.40.1160.10
2bmu
Ump kinase from pyrococcus furiosus complexed with its substrate ump and its substrate analog amppnp
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (225 residues) CATH domain: 3.40.1160.10
Bound ligands:   Het Group U5P corresponds to enzyme reactant UMP
  Het Group ANP is 81.00% similar to enzyme product ADP
2bnd
The structure of e.Coli ump kinase in complex with udp
Source: Escherichia coli. Organism_taxid: 562. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (237 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group UDP corresponds to enzyme product UDP
2bne
The structure of e. Coli ump kinase in complex with ump
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (234 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group U5P corresponds to enzyme reactant UMP
2bnf
The structure of e. Coli ump kinase in complex with utp
Source: Escherichia coli. Organism_taxid: 83333. Strain: k12. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (236 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group UTP is 86.00% similar to enzyme product UDP
2bri
Ump kinase from pyrococcus furiosus complexed with its substrate analog amppnp
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (225 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
2brx
Ump kinase from pyrococcus furiosus without ligands
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (218 residues) CATH domain: 3.40.1160.10
2ij9
Crystal structure of uridylate kinase from archaeoglobus ful
Source: Archaeoglobus fulgidus. Organism_taxid: 224325. Strain: dsm 4304. Gene: pyrh, af_2042. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (214 residues)
2j4j
Crystal structure of uridylate kinase from sulfolobus solfataricus in complex with ump and amppcp to 2.1 angstrom resolution
Source: Sulfolobus solfataricus. Organism_taxid: 273057. Strain: p2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (216 residues) CATH domain: Unassigned
Bound ligands:   Het Group U5P corresponds to enzyme reactant UMP
  Het Group ACP is 81.00% similar to enzyme product ADP
  Het Group 4TC is 46.00% similar to enzyme product UDP
2j4k
Crystal structure of uridylate kinase from sulfolobus solfataricus in complex with ump to 2.2 angstrom resolution
Source: Sulfolobus solfataricus. Organism_taxid: 273057. Strain: p2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (207 residues) CATH domain: Unassigned
Bound ligand:   Het Group U5P corresponds to enzyme reactant UMP
2j4l
Crystal structure of uridylate kinase from sulfolobus solfataricus in complex with utp to 2.8 angstrom resolution
Source: Sulfolobus solfataricus. Organism_taxid: 2287. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L (214 residues) CATH domain: Unassigned
Bound ligand:   Het Group UTP is 86.00% similar to enzyme product UDP
2ji5
Structure of ump kinase from pyrococcus furiosus complexed with utp
Source: Pyrococcus furiosus. Organism_taxid: 2261. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (219 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group UTP is 86.00% similar to enzyme product UDP
2jjx
The crystal structure of ump kinase from bacillus anthracis (ba1797)
Source: Bacillus anthracis. Organism_taxid: 198094. Strain: ames. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (244 residues) CATH domain: 3.40.1160.10
2v4y
The structure of e. Coli ump kinase in complex with its allosteric regulator gtp
Source: Escherichia coli. Organism_taxid: 83333. Strain: k-12. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: pdia17.
Chains: A, B, C, D, E, F (237 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group GTP is 96.88% similar to enzyme reactant ATP
2va1
Crystal structure of ump kinase from ureaplasma parvum
Source: Ureaplasma parvum. Organism_taxid: 134821. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (226 residues) CATH domain: 3.40.1160.10
3ek5
Unique gtp-binding pocket and allostery of ump kinase from a negative phytopathogen bacterium
Source: Xanthomonas campestris pv. Campestris. Organism_taxid: 340. Strain: xc17. Gene: pyrh, xcc1371. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (242 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group GTP is 96.88% similar to enzyme reactant ATP
3ek6
Unique gtp-binding pocket and allostery of ump kinase from a negative phytopathogen bacterium
Source: Xanthomonas campestris pv. Campestris. Organism_taxid: 340. Strain: xc17. Gene: pyrh, xcc1371. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (243 residues) CATH domain: 3.40.1160.10
3nwy
Structure and allosteric regulation of the uridine monophosp kinase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: mt2951, mtcy274.14c, pyrh, rv2883c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (227 residues) CATH domain: 3.40.1160.10
Bound ligands:   Het Group GTP is 96.88% similar to enzyme reactant ATP
  Het Group UDP corresponds to enzyme product UDP
4a7w
Crystal structure of uridylate kinase from helicobacter pylori
Source: Helicobacter pylori. Organism_taxid: 85962. Strain: 26695. Atcc: 700392d. Expressed in: escherichia coli. Expression_system_taxid: 83333. Expression_system_variant: sg13009.
Chains: A, B (226 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group GTP is 96.88% similar to enzyme reactant ATP
4a7x
Crystal structure of uridylate kinase from helicobacter pylo
Source: Helicobacter pylori. Organism_taxid: 85962. Strain: 26695. Atcc: 700392d. Expressed in: escherichia coli. Expression_system_taxid: 83333. Expression_system_variant: sg13009.
Chains: A, B, C, D, E, F (234 residues) CATH domain: 3.40.1160.10
Bound ligand:   Het Group UDP corresponds to enzyme product UDP