_EC 2.7.4.21 Inositol-hexakisphosphate kinase. 15 PDB entries  
EC 2.-.-.- Transferases. [17,772 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,822 PDB entries]
EC 2.7.4.- Phosphotransferases with a phosphate group as acceptor. [411 PDB entries]
EC 2.7.4.21 Inositol-hexakisphosphate kinase. [15 PDB entries]    
3t54

Reaction: (1) Atp + 1D-myo-inositol hexakisphosphate = adp + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. (2) Atp + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = Adp + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
 


ATP
+
1D-myo-inositol hexakisphosphate
=
ADP
+
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

ATP
+ 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
=
ADP
+ 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): ATP:1D-myo-inositol-hexakisphosphate phosphotransferase. IP6K.
Comments: Three mammalian isoforms are known to exist. Formerly Ec 2.7.1.152.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 15 PDB entries in enzyme class E.C.2.7.4.21

  PDB code Protein
3t54
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with atp an
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (318 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group ATP corresponds to enzyme reactant ATP
3t7a
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with adp at
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (319 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group ADP corresponds to enzyme product ADP
3t99
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with adp an absence of cadmium at ph 7.0
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (327 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group ADP corresponds to enzyme product ADP
  Het Group ADP corresponds to enzyme product ADP
3t9a
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (318 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group ANP is 81.25% similar to enzyme product ADP
3t9b
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (317 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group ANP is 81.25% similar to enzyme product ADP
3t9c
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp inositol hexakisphosphate (ip6)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group IHP corresponds to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group IHP is 88.89% similar to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
3t9d
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp (pp)-ip5 (5-ip7)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group I7P is 90.00% similar to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group I7P is 80.00% similar to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
3t9e
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with adp, 5 (5-ip7) and mgf3 (transition state mimic)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group I7P is 90.00% similar to enzyme reactant 1D-myo-inositol
  Het Group ADP corresponds to enzyme product ADP
  Het Group I7P is 80.00% similar to enzyme reactant 1D-myo-inositol
  Het Group ADP corresponds to enzyme product ADP
3t9f
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with adp an (pp)2-ip4 (1,5-ip8)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (318 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group I8P is 81.82% similar to enzyme reactant 1D-myo-inositol
  Het Group ADP corresponds to enzyme product ADP
  Het Group I8P is 72.73% similar to enzyme reactant 1D-myo-inositol
  Het Group ADP corresponds to enzyme product ADP
4hn2
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp substrate analog 5pa-ip5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hisppd1, kiaa0433, ppip5k2, vip2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group 0EJ is 74.42% similar to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group 0EJ is 82.05% similar to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
4nzm
Crystal structure of the catalytic domain of ppip5k2 in comp amppnp and 5-pa-insp5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2, hisppd1, kiaa0433, vip2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group 0EJ is 74.42% similar to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group ANP is 81.25% similar to enzyme product ADP
4nzn
Crystal structure of the catalytic domain of ppip5k2 in comp amppnp and 2-o-bn-5-pa-insp4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2, hisppd1, kiaa0433, vip2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group 2OU is 56.00% similar to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group ANP is 81.25% similar to enzyme product ADP
4nzo
Crystal structure of the catalytic domain of ppip5k2 in comp amppnp and 2,5-di-o-bn-insp4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2, hisppd1, kiaa0433, vip2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (325 residues) CATH domains: Unassigned Unassigned
Bound ligands:   Het Group 2OV is 56.00% similar to enzyme reactant 1D-myo-inositol
  Het Group ANP is 81.25% similar to enzyme product ADP
  Het Group ANP is 81.25% similar to enzyme product ADP
4q4c
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with adp an synthetic 1,5-(pp)2-ip4 (1,5-ip8)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2, hisppd1, kiaa0433, vip2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (325 residues)
4q4d
Crystal structure of the catalytic domain of human diphospho pentakisphosphate kinase 2 (ppip5k2) in complex with amp-pn synthetic 3,5-(pp)2-ip4 (3,5-ip8)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppip5k2, hisppd1, kiaa0433, vip2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (317 residues)