_EC 2.7.11.8 Fas-activated serine/threonine kinase. 0 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,916 PDB entries]
EC 2.7.11.- Protein-serine/threonine kinases. [2,980 PDB entries]
EC 2.7.11.8 Fas-activated serine/threonine kinase. [-]    

Reaction: Atp + [Fas-activated serine/threonine protein] = adp + [Fas-activated serine/threonine phosphoprotein].
 


ATP
+ [Fas-activated serine/threonine protein]
=
ADP
+ [Fas-activated serine/threonine phosphoprotein]
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Fast. Fastk.
Comments: This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of Dna fragmentation. Formerly Ec 2.7.1.37.
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There are no PDB entries in enzyme class E.C.2.7.11.8