_EC 2.7.11.30 Receptor protein serine/threonine kinase. 55 PDB entries  
EC 2.-.-.- Transferases. [18,188 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [11,027 PDB entries]
EC 2.7.11.- Protein-serine/threonine kinases. [3,005 PDB entries]
EC 2.7.11.30 Receptor protein serine/threonine kinase. [55 PDB entries]    
1b6c

Reaction: Atp + [receptor-protein] = adp + [receptor-protein] phosphate.
 


ATP
+ [receptor-protein]
=
ADP
+ [receptor-protein] phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Activin receptor kinase. Receptor serine/threonine protein kinase. Receptor type I serine/threonine protein kinase. Receptor type Ii serine/threonine protein kinase. TGF-beta kinase.
Comments: The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signaling occurs by the binding of ligand to the type Ii receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. Formerly Ec 2.7.1.37.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 55 PDB entries in enzyme class E.C.2.7.11.30

  PDB code Protein
1b6c
Crystal structure of the cytoplasmic domain of the type i tgf-beta receptor in complex with fkbp12
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: plys s. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, D, F, H (326 residues) CATH domains: 3.30.200.20 1.10.510.10
1bte
Crystal structure of the extracellular domain of the type ii receptor
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: pichia pastoris. Expression_system_taxid: 4922.
Chains: A, B (92 residues) CATH domain: 2.10.60.10
Bound ligand:   Het Group NAG is 41.38% similar to enzyme product ADP
1es7
Complex between bmp-2 and two bmp receptor ia ectodomains
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, D (83 residues) CATH domain: 2.10.60.10
1ias
Cytoplasmic domain of unphosphorylated type i tgf-beta receptor crystallized without fkbp12
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D, E (330 residues) CATH domains: 3.30.200.20 1.10.510.10
1ks6
Transforming growth factor beta type ii receptor ligand binding domain
Source: Gallus gallus. Chicken. Organism_taxid: 9031. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (107 residues) CATH domain: 2.10.60.10
1ktz
Crystal structure of the human tgf-beta type ii receptor extracellular domain in complex with tgf-beta3
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: B (106 residues) CATH domain: 2.10.60.10
1lx5
Crystal structure of the bmp7/actrii extracellular domain co
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp7. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary cells. Other_details: dhfr-. Mus musculus.
Chain: B (94 residues) CATH domain: 2.10.60.10
Bound ligand:   Het Group NAG is 41.38% similar to enzyme product ADP
1m9z
Crystal structure of human tgf-beta type ii receptor ligand domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (105 residues) CATH domain: 2.10.60.10
1nys
Crystal structure of activin a bound to the ecd of actriib p41
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: actriib. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.
Chains: A, C (91 residues) CATH domain: 2.10.60.10
1nyu
Crystal structure of activin a bound to the ecd of actriib
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: actriib. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.
Chains: A, C (92 residues) CATH domain: 2.10.60.10
1plo
Transforming growth factor-beta type ii receptor extracellular domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (122 residues) CATH domain: 2.10.60.10
1py5
Crystal structure of tgf-beta receptor i kinase with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
1rew
Structural refinement of the complex of bone morphogenetic p and its type ia receptor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: C, D (86 residues) CATH domain: 2.10.60.10
1rw8
Crystal structure of tgf-beta receptor i kinase with atp site inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tru. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
1s4y
Crystal structure of the activin/actriib extracellular domai
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: acvr2b. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chains: A, C (91 residues) CATH domain: 2.10.60.10
1vjy
Crystal structure of a naphthyridine inhibitor of human tgf- beta type i receptor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (299 residues) CATH domains: 3.30.200.20 1.10.510.10
2goo
Ternary complex of bmp-2 bound to bmpr-ia-ecd and actrii-ecd
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a. Mus musculus. House mouse.
Chains: B, C, E, F (85 residues) CATH domain: 2.10.60.10
Bound ligand:   Het Group NDG is 40.00% similar to enzyme product ADP
2h62
Crystal structure of a ternary ligand-receptor complex of bmp-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3. Expression_system_taxid: 562
Chains: C, D (84 residues) CATH domain: 2.10.60.10
2h64
Crystal structure of a ternary ligand-receptor complex of bmp-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3. Mus musculus. House mouse.
Chains: B, C (92 residues) CATH domain: 2.10.60.10
2hlq
Crystal structure of the extracellular domain of the type ii bmp receptor
Source: Ovis aries. Sheep. Organism_taxid: 9940. Gene: bmprii. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (100 residues) CATH domain: 2.10.60.10
2k3g
Nmr structure analysis of a bmp receptor
Source: Homo sapiens. Gene: bmpr1a, acvrlk3, alk3. Expressed in: escherichia coli.
Chain: A (102 residues) CATH domain: 2.10.60.10
2l5s
Solution structure of the extracellular domain of the tgf-be receptor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (88 residues) CATH domain: 2.10.60.10
2lcr
Nmr structure of alk1 extracellular domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvrl1, acvrlk1, alk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (97 residues) CATH domain: Unassigned
2pjy
Structural basis for cooperative assembly of the tgf-beta si complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tgfbr2. Gene: tgfbr1. Expression_system_taxid: 562
Chains: B, C (108 residues) CATH domain: 2.10.60.10
2qj9
Crystal structure analysis of bmp-2 in complex with bmpr-ia
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3.
Chains: D, C (93 residues) CATH domain: 2.10.60.10
2qja
Crystal structure analysis of bmp-2 in complex with bmpr-ia b12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3.
Chains: C, D (85 residues) CATH domain: 2.10.60.10
2qjb
Crystal structure analysis of bmp-2 in complex with bmpr-ia ia/ib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp2, bmp2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a, acvrlk3, alk3.
Chains: C, D (85 residues) CATH domain: 2.10.60.10
2qlu
Crystal structure of activin receptor type ii kinase domain from human
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10
2wot
Alk5 in complex with 4-((5,6-dimethyl-2-(2-pyridyl)-3- pyridyl)oxy)-n-(3,4,5-trimethoxyphenyl)pyridin-2-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (303 residues) CATH domains: 3.30.200.20 1.10.510.10
2wou
Alk5 in complex with 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2- pyridyl)amino)benzenesulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (299 residues) CATH domains: 3.30.200.20 1.10.510.10
2x7o
Crystal structure of tgfbri complexed with an indolinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D, E (330 residues) CATH domains: 3.30.200.20 1.10.510.10
3evs
Crystal structure of the gdf-5:bmp receptor ib complex.
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: u2os. Gene: cdmp1, gdf5. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse.
Chain: C (85 residues) CATH domain: 2.10.60.10
3faa
Crystal structure of tgfbri complexed with a 2- aminoimidazole inhibitor
Source: Homo sapiens. Organism_taxid: 9606. Cell_line: sf9. Gene: tgfbr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D, E (328 residues) CATH domains: 3.30.200.20 1.10.510.10
3g2f
Crystal structure of the kinase domain of bone morphogenetic receptor type ii (bmpr2) at 2.35 a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmpr2, pph1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (305 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
3gxj
Structure of alk5 + gw855857
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
3gxl
Alk-5 kinase complex with gw857175
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
3h9r
Crystal structure of the kinase domain of type i activin rec (acvr1) in complex with fkbp12 and dorsomorphin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: baculovirus. Expression_system_taxid: 10469. Gene: fkbp1, fkbp12, fkbp1a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (312 residues) CATH domains: 3.30.200.20 1.10.510.10
3hmm
Structure of alk5 + gw855857
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
3kcf
Crystal structure of tgfbri complexed with a pyrazolone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, tgfbri. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D, E (328 residues) CATH domains: 3.30.200.20 1.10.510.10
3kfd
Ternary complex of tgf-b1 reveals isoform-specific ligand re and receptor recruitment in the superfamily
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfb1, tgfb. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_organ: ovary cells. Gene: tgfbr2. Expressed in: escherichia coli.
Chains: E, F, I, J, G, H, K, L (108 residues) CATH domain: 2.10.60.10
3mdy
Crystal structure of the cytoplasmic domain of the bone morp protein receptor type-1b (bmpr1b) in complex with fkbp12 an 193189
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmpr1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: fkbp12. Expressed in: escherichia coli.
Chains: A, C (320 residues) CATH domains: 3.30.200.20 1.10.510.10
3mtf
Crystal structure of the acvr1 kinase in complex with a 2- aminopyridine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (296 residues) CATH domains: 3.30.200.20 1.10.510.10
3my0
Crystal structure of the acvrl1 (alk1) kinase domain bound t 193189
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvrl1, acvrl1 (alk1), acvrlk1, alk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X (296 residues) CATH domains: 3.30.200.20 1.10.510.10
3nh7
Crystal structure of the neutralizing fab fragment abd1556 b the bmp type i receptor ia
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: bmpr1a. Expression_system_taxid: 469008.
Chains: A, B, C, D (85 residues) CATH domain: 2.10.60.10
3oom
Crystal structure of the acvr1 kinase domain in complex with imidazo[1,2-b]pyridazine inhibitor k00507
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10
3q4t
Crystal structure of activin receptor type-iia (acvr2a) kina in complex with dorsomorphin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2, acvr2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (305 residues) CATH domains: 3.30.200.20 1.10.510.10
3q4u
Crystal structure of the acvr1 kinase domain in complex with 193189
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B, C, D (298 residues) CATH domains: 3.30.200.20 1.10.510.10
3qb4
Crystal structure of a tgf-beta ligand-receptor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdmp1, gdf5. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: acvrlk3, alk3, bmpr1a.
Chains: B, D (88 residues) CATH domain: 2.10.60.10
3soc
Crystal structure of activin receptor type-iia (acvr2a) kina in complex with a quinazolin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr2, acvr2a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (307 residues) CATH domains: 3.30.200.20 1.10.510.10
3tzm
Tgf-beta receptor type 1 in complex with sb431542
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tgfbr1, alk5, skr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10
4asx
Crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dihydro-bauerinE C
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (310 residues) CATH domains: 3.30.200.20 1.10.510.10
4bgg
Crystal structure of the acvr1 kinase in complex with ldn-21
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: site-directed mutagenesis
Chains: A, B, C, D (296 residues) CATH domains: 3.30.200.20 1.10.510.10
4c02
Crystal structure of human acvr1 (alk2) in complex with fkbp12.6 and dorsomorphin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta plyss.
Chain: A (313 residues) CATH domains: 3.30.200.20 1.10.510.10
4dym
Crystal structure of the acvr1 kinase domain in complex with imidazo[1,2-b]pyridazine inhibitor k00135
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: acvr1, acvrlk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
4fao
Specificity and structure of a high affinity activin-like 1 signaling complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bmp9, gdf2. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: acvrl1, acvrlk1, alk1. Gene: actriib, acvr2b.
Chains: C, D, E, F, I, J, K, L, O, P, Q, R, U, V, W, X, c, d, e, f, i, j, k, l (75 residues) CATH domain: Unassigned
Bound ligand:   Het Group NAG is 41.38% similar to enzyme product ADP