_EC 2.7.11.27 [Acetyl-CoA carboxylase] kinase. 18 PDB entries  
EC 2.-.-.- Transferases. [16,521 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,144 PDB entries]
EC 2.7.11.- Protein-serine/threonine kinases. [2,765 PDB entries]
EC 2.7.11.27 [Acetyl-CoA carboxylase] kinase. [18 PDB entries]    
2h6d

Reaction: Atp + [acetyl-CoA carboxylase] = adp + [acetyl-CoA carboxylase] phosphate.
 


ATP
+
[acetyl-CoA carboxylase]
=
ADP
+
[acetyl-CoA carboxylase] phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Acetyl coenzyme A carboxylase kinase (phosphorylating). Acetyl-CoA carboxylase bound kinase. Acetyl-CoA carboxylase kinase. Acetyl-CoA carboxylase kinase (AMP-activated). Acetyl-CoA carboxylase kinase (cAMP-independent). Acetyl-coenzyme A carboxylase kinase. Ampk. I-peptide kinase.
Comments: Phosphorylates and inactivates Ec 6.4.1.2, which can be dephosphorylated and reactivated by Ec 3.1.3.17. More active toward the dimeric form of acetyl-CoA carboxylase than the polymeric form. Phosphorylates serine residues. Formerly Ec 2.7.1.111 and Ec 2.7.1.128.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 18 PDB entries in enzyme class E.C.2.7.11.27

  PDB code Protein
2h6d
Protein kinase domain of the human 5'-amp-activated protein kinase catalytic subunit alpha-2 (ampk alpha-2 chain)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prkaa2, ampk, ampk2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (256 residues) CATH domains: 3.30.200.20 1.10.510.10
2ltu
Solution structure of autoinhibitory domain of human amp-act protein kinase catalytic subunit
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (62 residues) CATH domain: 0.0.0.0
2v8q
Crystal structure of the regulatory fragment of mammalian ampk in complexes with amp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: 3.30.310.80
2v92
Crystal structure of the regulatory fragment of mammalian ampk in complexes with atp-amp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: 3.30.310.80
2v9j
Crystal structure of the regulatory fragment of mammalian ampk in complexes with mg.Atp-amp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: 3.30.310.80
2y8l
Structure of the regulatory fragment of mammalian ampk in co with two adp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (104 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group ADP corresponds to enzyme product ATP
2y8q
Structure of the regulatory fragment of mammalian ampk in co with one adp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (104 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group ADP corresponds to enzyme product ATP
2ya3
Structure of the regulatory fragment of mammalian ampk in co with coumarin adp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: 3.30.310.80
2yza
Crystal structure of kinase domain of human 5'-amp-activated kinase alpha-2 subunit mutant (t172d)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prkaa2, ampk, ampk2. Expressed in: cell-free protein synthesis.
Chain: A (258 residues) CATH domains: 3.30.200.20 1.10.510.10
3aqv
Human amp-activated protein kinase alpha 2 subunit kinase do (t172d) complexed with compound c
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cell-free protein synthesis.
Chain: A (267 residues) CATH domains: 3.30.200.20 1.10.510.10
4cfe
Structure of full length human ampk in complex with a small molecule activator, a benzimidazole derivative (991)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (426 residues)
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ATP
4cff
Structure of full length human ampk in complex with a small molecule activator, a thienopyridone derivative (a-769662)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (425 residues)
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ATP
4cfh
Structure of an active form of mammalian ampk
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chains: A, C (402 residues)
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ATP
4eai
Co-crystal structure of an ampk core with amp
Source: Rattus norvegicus, synthetic, rattus norvegicus. Rat. Organism_taxid: 10116, 32630, 10116. Gene: prkaa1, ampk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human.
Chain: A (100 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ATP
4eaj
Co-crystal of ampk core with amp soaked with atp
Source: Rattus norvegicus, synthetic, rattus norvegicus. Rat. Organism_taxid: 10116, 32630, 10116. Gene: prkaa1, ampk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human.
Chain: A (100 residues) CATH domain: 0.0.0.0
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4eak
Co-crystal structure of an ampk core with atp
Source: Rattus norvegicus, synthetic, rattus norvegicus. Rat. Organism_taxid: 10116, 32630, 10116. Gene: prkaa1, ampk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Organism_taxid: 10116.
Chain: A (92 residues) CATH domain: 0.0.0.0
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4eal
Co-crystal of ampk core with atp soaked with amp
Source: Rattus norvegicus, synthetic, rattus norvegicus. Rat. Organism_taxid: 10116, 32630, 10116. Gene: prkaa1, ampk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Organism_taxid: 10116.
Chain: A (92 residues) CATH domain: 0.0.0.0
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ATP
4f2l
Structure of a regulatory domain of ampk
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: prkaa1, ampk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (61 residues) CATH domain: 0.0.0.0