_EC 2.7.11.22 Cyclin-dependent kinase. 420 PDB entries  
EC 2.-.-.- Transferases. [17,766 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,813 PDB entries]
EC 2.7.11.- Protein-serine/threonine kinases. [2,952 PDB entries]
EC 2.7.11.22 Cyclin-dependent kinase. [420 PDB entries]    
1aq1

Reaction: Atp + a protein = adp + a phosphoprotein.
 


ATP
+
protein
=
ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Cdc2 kinase. Cdk-activating kinase. Cdk-activating protein kinase.
Comments: Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. Formerly Ec 2.7.1.37.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 420 PDB entries in enzyme class E.C.2.7.11.22

  PDB code Protein
1aq1
Human cyclin dependent kinase 2 complexed with the inhibitor staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
1b38
Human cyclin-dependent kinase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1b39
Human cyclin-dependent kinase 2 phosphorylated on thr 160
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1bi7
Mechanism of g1 cyclin dependent kinase inhibition from the structure of the cdk6-p16ink4a tumor suppressor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: spodoptera frugiperda. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
1bi8
Mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: spodoptera frugiperda. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (264 residues) CATH domains: 3.30.200.20 1.10.510.10
1blx
P19ink4d/cdk6 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Mus musculus. House mouse.
Chain: A (305 residues) CATH domains: 3.30.200.20 1.10.510.10
1buh
Crystal structure of the human cdk2 kinase complex with cell cycle-regulatory protein ckshs1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
1ckp
Human cyclin dependent kinase 2 complexed with the inhibitor purvalanol b
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group PVB is 50.00% similar to enzyme product ADP
1di8
The structure of cyclin-dependent kinase 2 (cdk2) in complex with 4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_cell: t.Ni
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group DTQ is 40.00% similar to enzyme product ADP
1dm2
Human cyclin-dependent kinase 2 complexed with the inhibitor hymenialdisine
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9 cells. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
1e1v
Human cyclin dependent kinase 2 complexed with the inhibitor nu2058
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group CMG is 40.00% similar to enzyme product ADP
1e1x
Human cyclin dependent kinase 2 complexed with the inhibitor nu6027
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
1e9h
Thr 160 phosphorylated cdk2 - human cyclin a3 complex with the inhibitor indirubin-5-sulphonate bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
1f5q
Crystal structure of murine gamma herpesvirus cyclin complexed to human cyclin dependent kinase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9 insect cells. Murid herpesvirus 4. Murine herpesvirus 68. Organism_taxid: 33708.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
1fin
Cyclin a-cyclin-dependent kinase 2 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: the fragment used in the crystallization
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1fq1
Crystal structure of kinase associated phosphatase (kap) in complex with phospho-cdk2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: homo sapiens. Other_details: homo sapiens
Chain: B (296 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1fvt
The structure of cyclin-dependent kinase 2 (cdk2) in complex with an oxindole inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
1fvv
The structure of cdk2/cyclin a in complex with an oxindole inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
1g3n
Structure of a p18(ink4c)-cdk6-k-cyclin ternary complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyclin-dependent kinase 6. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Gene: p18(ink4c). Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, E (293 residues) CATH domains: 3.30.200.20 1.10.510.10
1g5s
Crystal structure of human cyclin dependent kinase 2 (cdk2) in complex with the inhibitor h717
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10
1gih
Human cyclin dependent kinase 2 complexed with the cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
1gii
Human cyclin dependent kinase 2 complexed with the cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
1gij
Human cyclin dependent kinase 2 complexed with the cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
1gy3
Pcdk2/cyclin a in complex with mgadp, nitrate and peptide su
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: cdk2 was co-expressed with cak1 - produce th phospho-cdk2. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme product ADP
1gz8
Human cyclin dependent kinase 2 complexed with the inhibitor 2-amino-6-(3'-methyl-2'-oxo)butoxypurine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
1h00
Cdk2 in complex with a disubstituted 4, 6-bis anilino pyrimidine cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
1h01
Cdk2 in complex with a disubstituted 2, 4-bis anilino pyrimidine cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
1h07
Cdk2 in complex with a disubstituted 4, 6-bis anilino pyrimidine cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
1h08
Cdk2 in complex with a disubstituted 2, 4-bis anilino pyrimidine cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
1h0v
Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-amino-6-[(r)-pyrrolidino-5'-yl]methoxypurine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group UN4 is 40.00% similar to enzyme product ADP
1h0w
Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-amino-6-[cyclohex-3-enyl]methoxypurine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
1h1p
Structure of human thr160-phospho cdk2/cyclin a complexed with the inhibitor nu2058
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group CMG is 40.00% similar to enzyme product ADP
1h1q
Structure of human thr160-phospho cdk2/cyclin a complexed with the inhibitor nu6094
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group 2A6 is 41.00% similar to enzyme product ADP
1h1r
Structure of human thr160-phospho cdk2/cyclin a complexed with the inhibitor nu6086
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group 6CP is 40.00% similar to enzyme product ADP
1h1s
Structure of human thr160-phospho cdk2/cyclin a complexed with the inhibitor nu6102
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
1h24
Cdk2/cyclin a in complex with a 9 residue recruitment peptide from e2f
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1h25
Cdk2/cyclin a in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1h26
Cdk2/cyclin a in complex with an 11-residue recruitment peptide from p53
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
1h27
Cdk2/cyclin a in complex with an 11-residue recruitment pept p27
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group PRO is 41.18% similar to enzyme reactant protein
1h28
Cdk2/cyclin a in complex with an 11-residue recruitment pept p107
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
1h4l
Structure and regulation of the cdk5-p25(nck5a) complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Organism_taxid: 9606
Chains: A, B (278 residues) CATH domains: 3.30.200.20 1.10.510.10
1hck
Human cyclin-dependent kinase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1hcl
Human cyclin-dependent kinase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1jow
Crystal structure of a complex of human cdk6 and a viral cyclin
Source: Saimiriine herpesvirus 2. Herpesvirus saimiri. Organism_taxid: 10381. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Homo sapiens. Human. Organism_taxid: 9606.
Chain: B (277 residues) CATH domains: 3.30.200.20 1.10.510.10
1jst
Phosphorylated cyclin-dependent kinase-2 bound to cyclin a
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Other_details: cyclin a-bound form phosphorylated on thr 16 vitro using a cdk-activating kinase consisting of the cycli complex.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1jsu
P27(kip1)/cyclin a/cdk2 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: cyclin a-bound form phosphorylated on thr 160 in vitro using a cdk-activating kinase consisting of
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
1jsv
The structure of cyclin-dependent kinase 2 (cdk2) in complex with 4-[(6-amino-4-pyrimidinyl) amino]benzenesulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high-five insect cells.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group U55 is 40.00% similar to enzyme product ADP
1jvp
Crystal structure of human cdk2 (unphosphorylated) in complex with pkf049-365
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: h5 (trichoplusia ni).
Chain: P (281 residues) CATH domains: 3.30.200.20 1.10.510.10
1ke5
Cdk2 complexed with n-methyl-4-{[(2-oxo-1,2-dihydro-3h- indol-3-ylidene)methyl]amino}benzenesulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
1ke6
Cyclin-dependent kinase 2 (cdk2) complexed with n-methyl-{4- [2-(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8- ylidene)hydrazino]phenyl}methanesulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
1ke7
Cyclin-dependent kinase 2 (cdk2) complexed with 3-{[(2,2- dioxido-1,3-dihydro-2-benzothien-5-yl)amino]methylene}-5- (1,3-oxazol-5-yl)-1,3-dihydro-2h-indol-2-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
1ke8
Cyclin-dependent kinase 2 (cdk2) complexed with 4-{[(2-oxo- 1,2-dihydro-3h-indol-3-ylidene)methyl]amino}-n-(1,3- thiazol-2-yl)benzenesulfonamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
1ke9
Cyclin-dependent kinase 2 (cdk2) complexed with 3-{[4- ({[amino(imino)methyl]aminosulfonyl)anilino]methylene}-2- oxo-2,3-dihydro-1h-indole
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
1ob3
Structure of p. Falciparum pfpk5
Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (277 residues) CATH domains: 3.30.200.20 1.10.510.10
1ogu
Structure of human thr160-phospho cdk2/cyclin a complexed with a 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
1oi9
Structure of human thr160-phospho cdk2/cyclin a complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group N20 is 44.00% similar to enzyme product ADP
1oiq
Imidazopyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (264 residues) CATH domains: 3.30.200.20 1.10.510.10
1oir
Imidazopyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
1oit
Imidazopyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
1oiu
Structure of human thr160-phospho cdk2/cyclin a complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
1oiy
Structure of human thr160-phospho cdk2/cyclin a complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group N41 is 42.00% similar to enzyme product ADP
1okv
Cyclin a binding groove inhibitor h-arg-arg-leu-ile-phe-nh2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
1okw
Cyclin a binding groove inhibitor ac-arg-arg-leu-asn-(m-cl-p
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
1ol1
Cyclin a binding groove inhibitor h-cit-cit-leu-ile-(p-f-phe
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
1ol2
Cyclin a binding groove inhibitor h-arg-arg-leu-asn-(p-f-phe
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: cyclin groove-bound peptide h-arg-arg-leu-as phe)-nh2.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
1p2a
The structure of cyclin dependent kinase 2 (ckd2) with a trisubstituted naphthostyril inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chain: A (271 residues) CATH domains: 3.30.200.20 1.10.510.10
1p5e
The strucure of phospho-cdk2/cyclin a in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (tbs)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2 or ccna or ccn1.
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
1pf8
Crystal structure of human cyclin-dependent kinase 2 complex nucleoside inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
1pkd
The crystal structure of ucn-01 in complex with phospho- cdk2/cyclin a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2 or ccna or ccn1.
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
1pw2
Apo structure of human cyclin-dependent kinase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1pxi
Human cyclin dependent kinase 2 complexed with the inhibitor 4-(2,5-dichloro-thiophen-3-yl)-pyrimidin-2- ylamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1pxj
Human cyclin dependent kinase 2 complexed with the inhibitor 4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1pxk
Human cyclin dependent kinase 2 complexed with the inhibitor n-[4-(2,4-dimethyl-thiazol-5-yl)pyrimidin-2-yl]- n'-hydroxyiminoformamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
1pxl
Human cyclin dependent kinase 2 complexed with the inhibitor [4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]- (4-trifluoromethyl-phenyl)-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
1pxm
Human cyclin dependent kinase 2 complexed with the inhibitor 3-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2- ylamino]-phenol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
1pxn
Human cyclin dependent kinase 2 complexed with the inhibitor 4-[4-(4-methyl-2-methylamino-thiazol-5-yl)- pyrimidin-2-ylamino]-phenol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1pxo
Human cyclin dependent kinase 2 complexed with the inhibitor [4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2- yl]-(3-nitro-phenyl)-amine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1pxp
Human cyclin dependent kinase 2 complexed with the inhibitor n-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]- n',n'-dimethyl-benzene-1,4-diamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
1pye
Crystal structure of cdk2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (266 residues) CATH domains: 3.30.200.20 1.10.510.10
1qmz
Phosphorylated cdk2-cyclyin a-substrate peptide complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: cyclin a-bound form phosphorylated source coexpression with cak1p. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1r78
Cdk2 complex with a 4-alkynyl oxindole inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
1ua2
Crystal structure of human cdk7
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: sf21 cells in culture
Chains: A, B, C, D (287 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1ung
Structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (288 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ALH is 42.42% similar to enzyme product ADP
1unh
Structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (277 residues) CATH domains: 3.30.200.20 1.10.510.10
1unl
Structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (292 residues) CATH domains: 3.30.200.20 1.10.510.10
1urc
Cyclin a binding groove inhibitor ace-arg-lys-leu-phe-gly
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: cyclin groove-bound cyclic(2-5) pentapeptide
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
1urw
Cdk2 in complex with an imidazo[1,2-b]pyridazine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10
1v0b
Crystal structure of the t198a mutant of pfpk5
Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (287 residues) CATH domains: 3.30.200.20 1.10.510.10
1v0o
Structure of p. Falciparum pfpk5-indirubin-5-sulphonate ligand complex
Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (277 residues) CATH domains: 3.30.200.20 1.10.510.10
1v0p
Structure of p. Falciparum pfpk5-purvalanol b ligand complex
Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (277 residues) CATH domains: 3.30.200.20 1.10.510.10
1v1k
Cdk2 in complex with a disubstituted 4, 6-bis anilino pyrimidine cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10
1vyw
Structure of cdk2/cyclin a with pnu-292137
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: highfive. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10
1vyz
Structure of cdk2 complexed with pnu-181227
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: highfive.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
1w0x
Crystal structure of human cdk2 in complex with the inhibitor olomoucine.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: C (280 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group OLO is 44.12% similar to enzyme product ADP
1w8c
Co-crystal structure of 6-cyclohexylmethoxy-8-isopropyl-9h- purin-2-ylamine and monomeric cdk2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
1w98
The structural basis of cdk2 activation by cyclin e
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
1wcc
Screening for fragment binding by x-ray crystallography
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group CIG is 46.15% similar to enzyme reactant protein
1xo2
Crystal structure of a human cyclin-dependent kinase 6 compl flavonol inhibitor, fisetin
Source: Saimiriine herpesvirus 2. Herpesvirus saimiri. Organism_taxid: 10381. Gene: 72, eclf2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: sf-9. Homo sapiens. Human.
Chain: B (289 residues) CATH domains: 3.30.200.20 1.10.510.10
1y8y
Crystal structure of human cdk2 complexed with a pyrazolo[1, 5-a]pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
1y91
Crystal structure of human cdk2 complexed with a pyrazolo[1, 5-a]pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
1ykr
Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2a0c
Human cdk2 in complex with olomoucine ii, a novel 2,6,9- trisubstituted purine cyclin-dependent kinase inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2.
Chain: X (294 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group CK9 is 42.00% similar to enzyme product ADP
2a4l
Human cyclin-dependent kinase 2 in complex with roscovitine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9 cells.
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
2b52
Human cyclin dependent kinase 2 (cdk2) complexed with dph- 042562
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
2b53
Human cyclin dependent kinase 2 (cdk2) complexed with din- 234325
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
2b54
Human cyclin dependent kinase 2 (ckd2)complexed with din- 232305
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2b55
Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole din-101312
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
2bhe
Human cyclin dependent protein kinase 2 in complex with the inhibitor 5-bromo-indirubine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: insect cells
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2bhh
Human cyclin dependent protein kinase 2 in complex with the inhibitor 4-hydroxypiperindinesulfonyl-indirubine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2bkz
Structure of cdk2-cyclin a with pha-404611
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10
2bpm
Structure of cdk2-cyclin a with pha-630529
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10
2btr
Structure of cdk2 complexed with pnu-198873
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive.
Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10
2bts
Structure of cdk2 complexed with pnu-230032
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2c4g
Structure of cdk2-cyclin a with pha-533514
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (301 residues) CATH domains: 3.30.200.20 1.10.510.10
2c5n
Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9 insect cell. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2c5o
Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2c5v
Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2c5x
Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9 insect cell. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2c5y
Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design
Source: Homo sapiens. Human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2c68
Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor
Source: Homo sapiens. Human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2c69
Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor
Source: Homo sapiens. Human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2c6i
Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor
Source: Homo sapiens. Human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2c6k
Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor
Source: Homo sapiens. Human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2c6l
Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor
Source: Homo sapiens. Human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
2c6m
Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor
Source: Homo sapiens. Human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2c6o
Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor
Source: Homo sapiens. Human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2c6t
Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2cch
The crystal structure of cdk2 cyclin a in complex with a substrate peptide derived from cdc modified with a gamma- linked atp analogue
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2cci
Crystal structure of phospho-cdk2 cyclin a in complex with a peptide containing both the substrate and recruitment sites of cdc6
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2cjm
Mechanism of cdk inhibition by active site phosphorylation: cdk2 y15p t160p in complex with cyclin a structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (287 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2clx
4-arylazo-3,5-diamino-1h-pyrazole cdk inhibitors: sar study, crystal structure in complex with cdk2, selectivity, and cellular effects
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
2ds1
Human cyclin dependent kinase 2 complexed with the cdk4 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2duv
Structure of cdk2 with a 3-hydroxychromones
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2euf
X-ray structure of human cdk6-vcyclin in complex with the in pd0332991
Source: Herpesvirus saimiri (strain 11). Organism_taxid: 10383. Strain: 11. Gene: 72, eclf2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.
Chain: B (282 residues) CATH domains: 3.30.200.20 1.10.510.10
2exm
Human cdk2 in complex with isopentenyladenine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ZIP is 50.00% similar to enzyme product ADP
2f2c
X-ray structure of human cdk6-vcyclinwith the inhibitor aminopurvalanol
Source: Herpesvirus saimiri (strain 11). Organism_taxid: 10383. Strain: 11. Gene: 72, eclf2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.
Chain: B (280 residues) CATH domains: 3.30.200.20 1.10.510.10
2fvd
Cyclin dependent kinase 2 (cdk2) with diaminopyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
2g9x
Structure of thr 160 phosphorylated cdk2/cyclin a in complex inhibitor nu6271
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.
Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10
2i40
Cdk2/cyclin a complexed with a thiophene carboxamide inhibit
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, C (291 residues) CATH domains: 3.30.200.20 1.10.510.10
2iw6
Structure of human thr160-phospho cdk2-cyclin a complexed with a bisanilinopyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: wild type gene was a gift from dr d.O.Morgan other_details: full-length cyclin a was a gift from dr m.Do
Chains: A, C (293 residues) CATH domains: 3.30.200.20 1.10.510.10
2iw8
Structure of human thr160-phospho cdk2-cyclin a f82h-l83v- h84d mutant with an o6-cyclohexylmethylguanine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: wild type gene was a gift from dr d.O.Morgan other_details: full length cyclin a was a gift from dr m.Do
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2iw9
Structure of human thr160-phospho cdk2-cyclin a complexed with a bisanilinopyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: wild type gene was a gift from dr d.O.Morgan other_details: full length cyclin a was a gift from dr m.Do
Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10
2j9m
Crystal structure of cdk2 in complex with macrocyclic aminopyrimidine
Source: Homo sapiens. Human. Organism_taxid: 9606.
Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10
2jgz
Crystal structure of phospho-cdk2 in complex with cyclin b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10
2pk9
Structure of the pho85-pho80 cdk-cyclin complex of the phosphate-responsive signal transduction pathway
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: pho85, ssg3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: pho80, ags3, tup7, vac5.
Chains: A, C (287 residues) CATH domains: 3.30.200.20 1.10.510.10
2pmi
Structure of the pho85-pho80 cdk-cyclin complex of the phosp responsive signal transduction pathway with bound atp-gamma
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: pho85, ssg3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: pho80, ags3, tup7, vac5.
Chains: A, C (284 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AGS is 93.75% similar to enzyme reactant ATP
2r3f
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3g
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3h
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3i
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3j
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3k
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3l
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3m
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3n
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3o
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3p
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3q
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2r3r
Crystal structure of cyclin-dependent kinase 2 with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2r64
Crystal structure of a 3-aminoindazole compound with cdk2
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
2uue
Replace: a strategy for iterative design of cyclin binding groove inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2uzb
Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2uzd
Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2uze
Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2uzl
Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
2uzn
Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
2uzo
Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2v0d
Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2v22
Replace: a strategy for iterative design of cyclin binding groove inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2vta
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10
2vth
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10
2vti
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
2vtj
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
2vtl
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2vtm
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2vtn
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2vto
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
2vtp
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
2vtq
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2vtr
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2vts
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
2vtt
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2vu3
Identification of n-(4-piperidinyl)-4-(2,6- dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment- based x-ray crystallography and structure based drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
2vv9
Cdk2 in complex with an imidazole piperazine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
2w05
Structure of cdk2 in complex with an imidazolyl pyrimidine, compound 5b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
2w06
Structure of cdk2 in complex with an imidazolyl pyrimidine, compound 5c
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
2w17
Cdk2 in complex with the imidazole pyrimidine amide, compound (s)-8b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
2w1h
Fragment-based discovery of the pyrazol-4-yl urea (at9283), a multi-targeted kinase inhibitor with potent aurora kinase activity
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
2w96
Crystal structure of cdk4 in complex with a d-type cyclin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: B (267 residues) CATH domains: 3.30.200.20 1.10.510.10
2w99
Crystal structure of cdk4 in complex with a d-type cyclin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: B (291 residues) CATH domains: 3.30.200.20 1.10.510.10
2w9f
Crystal structure of cdk4 in complex with a d-type cyclin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: B (261 residues) CATH domains: 3.30.200.20 1.10.510.10
2w9z
Crystal structure of cdk4 in complex with a d-type cyclin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: B (287 residues) CATH domains: 3.30.200.20 1.10.510.10
2wev
Truncation and optimisation of peptide inhibitors of cdk2, cyclin a through structure guided design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2wfy
Truncation and optimisation of peptide inhibitors of cdk2, cyclin a through structure guided design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2whb
Truncation and optimisation of peptide inhibitors of cdk2, cyclin a through structure guided design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2wih
Structure of cdk2-cyclin a with pha-848125
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10
2wip
Structure of cdk2-cyclin a complexed with 8-anilino-1- methyl-4,5-dihydro-1h-pyrazolo[4,3-h] quinazoline-3- carboxylic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
2wma
Structural and thermodynamic consequences of cyclization of ligands for the recruitment site of cyclin a
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
2wmb
Structural and thermodynamic consequences of cyclization of ligands for the recruitment site of cyclin a
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
2wpa
Optimisation of 6,6-dimethyl pyrrolo 3,4-c pyrazoles: identification of pha-793887, a potent cdk inhibitor suitable for intravenous dosing
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10
2wxv
Structure of cdk2-cyclin a with a pyrazolo(4,3-h) quinazoline-3-carboxamide inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: highfive. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10
2x1n
Truncation and optimisation of peptide inhibitors of cdk2, cyclin a through structure guided design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2xmy
Discovery and characterisation of 2-anilino-4-(thiazol-5-yl) pyrimidine transcriptional cdk inhibitors as anticancer agents
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10
2xnb
Discovery and characterisation of 2-anilino-4-(thiazol-5-yl) pyrimidine transcriptional cdk inhibitors as anticancer agents
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (296 residues) CATH domains: 3.30.200.20 1.10.510.10
3bht
Structure of phosphorylated thr160 cdk2/cyclin a in complex inhibitor meriolin 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
3bhu
Structure of phosphorylated thr160 cdk2/cyclin a in complex inhibitor meriolin 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
3bhv
Structure of phosphorylated thr160 cdk2/cyclin a in complex with the inhibitor variolin b
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group VAR is 44.00% similar to enzyme product ADP
3blh
Crystal structure of human cdk9/cyclint1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
3blq
Crystal structure of human cdk9/cyclint1 in complex with atp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.
Chain: A (296 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
3blr
Crystal structure of human cdk9/cyclint1 in complex with flavopiridol
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
3ddp
Structure of phosphorylated thr160 cdk2/cyclin a in complex with the inhibitor cr8
Source: Homo sapiens. Human. Gene: cdk2. Expressed in: escherichia coli. Bos taurus. Bovine. Gene: ccna2, ccna.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
3ddq
Structure of phosphorylated thr160 cdk2/cyclin a in complex with the inhibitor roscovitine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Bos taurus. Bovine. Organism_taxid: 9913. Gene: ccna2, ccna.
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
3dog
Structure of thr 160 phosphorylated cdk2/cyclin a in complex with the inhibitor n-&-n1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Bos taurus. Bovine, cow. Organism_taxid: 9913. Gene: ccna2, ccna.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
3eid
Cdk2/cyclina complexed with a pyrazolopyridazine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (292 residues) CATH domains: 3.30.200.20 1.10.510.10
3ej1
Cdk2/cyclina complexed with a pyrazolopyridazine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10
3eoc
Cdk2/cyclina complexed with a imidazo triazin-2-amine
Source: Homo sapiens. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli.
Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10
3ezr
Cdk-2 with indazole inhibitor 17 bound at its active site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
3ezv
Cdk-2 with indazole inhibitor 9 bound at its active site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
3f5x
Cdk-2-cyclin complex with indazole inhibitor 9 bound at its site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
3fz1
Crystal structure of a benzthiophene inhibitor bound to human cyclin-dependent kinase-2 (cdk-2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdk2_human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
3g33
Crystal structure of cdk4/cyclin d3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnd3, hcg_16683. Expression_system_taxid: 7108
Chains: A, C (291 residues) CATH domains: 3.30.200.20 1.10.510.10
3ig7
Novel cdk-5 inhibitors - crystal structure of inhibitor efp with cdk-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
3igg
Novel cdk-5 inhibitors - crystal structure of inhibitor efq with cdk-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
3le6
The structure of cyclin dependent kinase 2 (ckd2) with a pyrazolobenzodiazepine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
3lfn
Crystal structure of cdk2 with sar57, an aminoindazole type inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
3lfq
Crystal structure of cdk2 with sar60, an aminoindazole type inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10
3lfs
Crystal structure of cdk2 with sar37, an aminoindazole type inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
3lq5
Structure of cdk9/cyclint in complex with s-cr8
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.
Chain: A (308 residues) CATH domains: 3.30.200.20 1.10.510.10
3mi9
Crystal structure of HIV-1 tat complexed with human p-tefb
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_cell_line: bl21 insect cells. K2420). Gene: ccnt1, cyclin t1. Human immunodeficiency virus type 1.
Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10
3mia
Crystal structure of HIV-1 tat complexed with atp-bound huma
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_cell: insect cells. K2420). Gene: ccnt1, cyclin t1. Human immunodeficiency virus type 1.
Chain: A (325 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
3mtl
Crystal structure of the pctaire1 kinase in complex with ind e804
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3my1
Structure of cdk9/cyclint1 in complex with drb
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.
Chain: A (315 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group RFZ is 46.88% similar to enzyme product ADP
3my5
Cdk2/cyclina in complex with drb
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Bovine. Organism_taxid: 9913.
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group RFZ is 46.88% similar to enzyme product ADP
3ns9
Crystal structure of cdk2 in complex with inhibitor bs-194
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10
3nup
Cdk6 (monomeric) in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (252 residues) CATH domains: 3.30.200.20 1.10.510.10
3nux
Cdk6 (monomeric) in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (261 residues) CATH domains: 3.30.200.20 1.10.510.10
3o0g
Crystal structure of cdk5:p25 in complex with an atp analogu
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk5. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: p25.
Chains: A, B (289 residues) CATH domains: 3.30.200.20 1.10.510.10
3pj8
Structure of cdk2 in complex with a pyrazolo[4,3-d]pyrimidin bioisostere of roscovitine.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
3pxf
Cdk2 in complex with two molecules of 8-anilino-1-naphthalen sulfonate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10
3pxq
Cdk2 in complex with 3 molecules of 8-anilino-1-naphthalene
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
3pxr
Apo cdk2 crystallized from jeffamine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3pxy
Cdk2 in complex with inhibitor jws648
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3pxz
Cdk2 ternary complex with jws648 and ans
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10
3py0
Cdk2 in complex with inhibitor su9516
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3py1
Cdk2 ternary complex with su9516 and ans
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10
3qhr
Structure of a pcdk2/cyclina transition-state mimic
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
3qhw
Structure of a pcdk2/cyclina transition-state mimic
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
3ql8
Cdk2 in complex with inhibitor jws-6-260
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qqf
Cdk2 in complex with inhibitor l1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qqg
Cdk2 in complex with inhibitor l2-5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qqh
Cdk2 in complex with inhibitor l2-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qqj
Cdk2 in complex with inhibitor l2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qqk
Cdk2 in complex with inhibitor l4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qql
Cdk2 in complex with inhibitor l3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qrt
Cdk2 in complex with inhibitor nsk-mc2-55
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qru
Cdk2 in complex with inhibitor nsk-mc1-12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10
3qtq
Cdk2 in complex with inhibitor rc-1-137
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qtr
Cdk2 in complex with inhibitor rc-1-148
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3qts
Cdk2 in complex with inhibitor rc-2-12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3qtu
Cdk2 in complex with inhibitor rc-2-132
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qtw
Cdk2 in complex with inhibitor rc-2-13
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qtx
Cdk2 in complex with inhibitor rc-2-35
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qtz
Cdk2 in complex with inhibitor rc-2-36
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qu0
Cdk2 in complex with inhibitor rc-2-38
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qwj
Cdk2 in complex with inhibitor kvr-1-142
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qwk
Cdk2 in complex with inhibitor kvr-1-150
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qx2
Cdk2 in complex with inhibitor kvr-1-190
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qx4
Cdk2 in complex with inhibitor kvr-1-78
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qxo
Cdk2 in complex with inhibitor kvr-1-84
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qxp
Cdk2 in complex with inhibitor rc-3-89
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qzf
Cdk2 in complex with inhibitor jws-6-52
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qzg
Cdk2 in complex with inhibitor jws-6-76
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qzh
Cdk2 in complex with inhibitor kvr-1-124
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3qzi
Cdk2 in complex with inhibitor kvr-1-126
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r1q
Cdk2 in complex with inhibitor kvr-1-102
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r1s
Cdk2 in complex with inhibitor kvr-1-127
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r1y
Cdk2 in complex with inhibitor kvr-1-134
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r28
Cdk2 in complex with inhibitor kvr-1-140
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r6x
Cdk2 in complex with inhibitor kvr-1-158
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r71
Cdk2 in complex with inhibitor kvr-1-162
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r73
Cdk2 in complex with inhibitor kvr-1-164
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r7e
Cdk2 in complex with inhibitor kvr-1-67
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r7i
Cdk2 in complex with inhibitor kvr-1-74
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3r7u
Cdk2 in complex with inhibitor kvr-1-75
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3r7v
Cdk2 in complex with inhibitor kvr-1-9
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r7y
Cdk2 in complex with inhibitor kvr-2-88
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r83
Cdk2 in complex with inhibitor kvr-2-92
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r8l
Cdk2 in complex with inhibitor l3-4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r8m
Cdk2 in complex with inhibitor l3-3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
3r8p
Cdk2 in complex with inhibitor nsk-mc1-6
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r8u
Cdk2 in complex with inhibitor rc-1-132
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r8v
Cdk2 in complex with inhibitor rc-1-135
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r8z
Cdk2 in complex with inhibitor rc-1-136
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
3r9d
Cdk2 in complex with inhibitor rc-2-135
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r9h
Cdk2 in complex with inhibitor rc-2-142
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3r9n
Cdk2 in complex with inhibitor rc-2-21
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3r9o
Cdk2 in complex with inhibitor rc-2-143
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3rah
Cdk2 in complex with inhibitor rc-2-22
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3rai
Cdk2 in complex with inhibitor kvr-1-160
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rak
Cdk2 in complex with inhibitor rc-2-32
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
3ral
Cdk2 in complex with inhibitor rc-2-34
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
3rgf
Crystal structure of human cdk8/cycc
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (321 residues) CATH domains: 3.30.200.20 1.10.510.10
3rjc
Cdk2 in complex with inhibitor l4-12
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rk5
Cdk2 in complex with inhibitor rc-2-72
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rk7
Cdk2 in complex with inhibitor rc-2-71
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rk9
Cdk2 in complex with inhibitor rc-2-74
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rkb
Cdk2 in complex with inhibitor rc-2-73
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rm6
Cdk2 in complex with inhibitor kvr-2-80
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
3rm7
Cdk2 in complex with inhibitor kvr-1-91
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rmf
Cdk2 in complex with inhibitor rc-2-33
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10
3rni
Cdk2 in complex with inhibitor rc-3-86
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3roy
Cdk2 in complex with inhibitor kvr-1-154
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rpo
Cdk2 in complex with inhibitor kvr-1-156
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3rpr
Cdk2 in complex with inhibitor rc-2-49
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3rpv
Cdk2 in complex with inhibitor rc-2-88
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A ( residues)
3rpy
Cdk2 in complex with inhibitor rc-2-40
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
3rzb
Cdk2 in complex with inhibitor rc-2-23
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
3s00
Cdk2 in complex with inhibitor l4-14
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3s0o
Cdk2 in complex with inhibitor rc-1-138
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
3s1h
Cdk2 in complex with inhibitor rc-2-39
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
3s2p
Crystal structure of cdk2 with a 2-aminopyrimidine compound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
3sqq
Cdk2 in complex with inhibitor rc-3-96
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
3sw4
Crystal structure of the cdk2 in complex with thiazolylpyrim inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
3sw7
Crystal structure of the cdk2 in complex with thiazolylpyrim inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
3ti1
Cdk2 in complex with sunitinib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3tiy
Cdk2 in complex with nsc 35676
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
3tiz
Cdk2 in complex with nsc 111848
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
3tn8
Cdk9/cyclin t in complex with can508
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.
Chain: A (305 residues) CATH domains: 3.30.200.20 1.10.510.10
3tnh
Cdk9/cyclin t in complex with can508
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnt1.
Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10
3tni
Structure of cdk9/cyclin t f241l
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnt1.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
3tnw
Structure of cdk2/cyclin a in complex with can508
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Bovine. Organism_taxid: 9913.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
3uli
Human cyclin dependent kinase 2 (cdk2) bound to azabenzimida derivative
Source: Homo sapiens. Human. Organism_taxid: 9606. Collection: 7108. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
3unj
Cdk2 in complex with inhibitor yl1-038-31
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
3unk
Cdk2 in complex with inhibitor yl5-083
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10
3wbl
Crystal structure of cdk2 in complex with pyrazolopyrimidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
3zdu
Crystal structure of the human cdkl3 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: site-directed mutagenesis
Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10
4aaa
Crystal structure of the human cdkl2 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10
4acm
Cdk2 in complex with 3-amino-6-(4-{[2-(dimethylamino)ethyl] sulfamoyl}-phenyl)-n-pyridin-3-ylpyrazine-2-carboxamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10
4agu
Crystal structure of the human cdkl1 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3 prare2. Other_details: mammalian gene collection
Chains: A, B, C (277 residues) CATH domains: 3.30.200.20 1.10.510.10
4au8
Crystal structure of compound 4a in complex with cdk5, showing an unusual binding mode to the hinge region via a water molecule
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (276 residues) CATH domains: 3.30.200.20 1.10.510.10
4aua
Liganded x-ray crystal structure of cyclin dependent kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (256 residues) CATH domains: 3.30.200.20 1.10.510.10
4bbm
Crystal structure of the human cdkl2 kinase domain with bound tcs 2312
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: site-directed mutagenesis
Chains: A, B (314 residues) CATH domains: 3.30.200.20 1.10.510.10
4bcf
Structure of cdk9 in complex with cyclin t and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (308 residues) CATH domains: 3.30.200.20 1.10.510.10
4bcg
Structure of cdk9 in complex with cyclin t and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (313 residues) CATH domains: 3.30.200.20 1.10.510.10
4bch
Structure of cdk9 in complex with cyclin t and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (309 residues) CATH domains: 3.30.200.20 1.10.510.10
4bci
Structure of cdk9 in complex with cyclin t and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (309 residues) CATH domains: 3.30.200.20 1.10.510.10
4bcj
Structure of cdk9 in complex with cyclin t and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (310 residues) CATH domains: 3.30.200.20 1.10.510.10
4bck
Structure of cdk2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10
4bcm
Structure of cdk2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
4bcn
Structure of cdk2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
4bco
Structure of cdk2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Bovine. Organism_taxid: 9913. Expression_system_taxid: 562
Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10
4bcp
Structure of cdk2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10
4bcq
Structure of cdk2 in complex with cyclin a and a 2-amino-4- heteroaryl-pyrimidine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913. Expression_system_taxid: 562
Chains: A, C (293 residues) CATH domains: 3.30.200.20 1.10.510.10
4bgh
Crystal structure of cdk2 in complex with pan-cdk inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10
4bgq
Crystal structure of the human cdkl5 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: site-directed mutagenesis
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
4bzd
Structure of cdk2 in complex with a benzimidazopyrimidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.
Chain: A (277 residues)
4cfn
Structure-based design of c8-substituted o6-cyclohexylmethox cdk1 and 2 inhibitors.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli b. Expression_system_taxid: 37762.
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
4cfw
Structure-based design of c8-substituted o6- cyclohexylmethoxyguanine cdk1 and 2 inhibitors.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli b. Expression_system_taxid: 37762.
Chains: A, C (300 residues) CATH domains: 3.30.200.20 1.10.510.10
4cjy
Crystal structure of the human cdk12-cyclink complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: C (304 residues) CATH domains: 3.30.200.20 1.10.510.10
4cxa
Crystal structure of the human cdk12-cyclin k complex bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, C (330 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
4ec8
Structure of full length cdk9 in complex with cyclint and dr
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Expression_system_taxid: 7108
Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10
4ec9
Crystal structure of full-length cdk9 in complex with cyclin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnt1.
Chain: A (307 residues) CATH domains: 3.30.200.20 1.10.510.10
4ek3
Crystal structure of apo cdk2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10
4ek4
Crystal structure of the cdk2 in complex with aminopyrazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
4ek5
Crystal structure of the cdk2 in complex with aminopyrazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
4ek6
Crystal structure of the cdk2 in complex with aminopyrazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
4ek8
Crystal structure of the cdk2 in complex with thiazolylpyrim inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
4eoi
Thr 160 phosphorylated cdk2 k89d, q131e - human cyclin a3 co the inhibitor ro3306
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10
4eoj
Thr 160 phosphorylated cdk2 h84s, q85m, k89d - human cyclin with atp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4eok
Thr 160 phosphorylated cdk2 h84s, q85m, k89d - human cyclin with the inhibitor nu6102
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10
4eol
Thr 160 phosphorylated cdk2 h84s, q85m, k89d - human cyclin with the inhibitor ro3306
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10
4eom
Thr 160 phosphorylated cdk2 h84s, q85m, q131e - human cyclin complex with atp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4eon
Thr 160 phosphorylated cdk2 h84s, q85m, q131e - human cyclin complex with the inhibitor ro3306
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (300 residues) CATH domains: 3.30.200.20 1.10.510.10
4eoo
Thr 160 phosphorylated cdk2 q131e - human cyclin a3 complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4eop
Thr 160 phosphorylated cdk2 q131e - human cyclin a3 complex inhibitor ro3306
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
4eoq
Thr 160 phosphorylated cdk2 wt - human cyclin a3 complex wit
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
4eor
Thr 160 phosphorylated cdk2 wt - human cyclin a3 complex wit inhibitor nu6102
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10
4eos
Thr 160 phosphorylated cdk2 wt - human cyclin a3 complex wit inhibitor ro3306
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562
Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10
4erw
Cdk2 in complex with staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
4ez3
Cdk2 in complex with nsc 134199
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
4ez5
Cdk6 (monomeric) in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (258 residues) CATH domains: 3.30.200.20 1.10.510.10
4ez7
Cdk2 in complex with staurosporine and 2 molecules of 8-anil naphthalene sulfonic acid
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10
4f6s
Crystal structure of human cdk8/cycc in complex with compoun tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (328 residues) CATH domains: 3.30.200.20 1.10.510.10
4f6u
Crystal structure of human cdk8/cycc in complex with compoun tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpho propyl]urea)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10
4f6w
Crystal structure of human cdk8/cycc in complex with compoun tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-4-[2-({[3-te 1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)ethyl]pi 1-carboxamide)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10
4f70
Crystal structure of human cdk8/cycc in complex with compoun tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpho ethyl]urea)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
4f7j
Crystal structure of human cdk8/cycc in complex with compoun tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxy urea)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10
4f7l
Crystal structure of human cdk8/cycc in complex with compoun butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5- yl]carbamoyl}amino)propyl]carbamate)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (328 residues) CATH domains: 3.30.200.20 1.10.510.10
4f7n
Crystal structure of human cdk8/cycc in complex with compoun [3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5- hydroxypentyl)urea)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10
4f7s
Crystal structure of human cdk8/cycc in the dmg-in conformat
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkg
Crystal structure of the cdk2 in complex with aminopyrazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
4fki
Crystal structure of the cdk2 in complex with aminopyrazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkj
Crystal structure of the cdk2 in complex with aminopyrazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkl
Crystal structure of the cdk2 in complex with thiazolylpyrim inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
4fko
Crystal structure of the cdk2 in complex with thiazolylpyrim inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkp
Crystal structure of the cdk2 in complex with oxindole inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkq
Crystal structure of the cdk2 in complex with oxindole inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkr
Crystal structure of the cdk2 in complex with oxindole inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
4fks
Crystal structure of the cdk2 in complex with oxindole inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkt
Crystal structure of the cdk2 in complex with oxindole inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
4fku
Crystal structure of the cdk2 in complex with oxindole inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkv
Crystal structure of the cdk2 in complex with oxindole inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
4fkw
Crystal structure of the cdk2 in complex with oxindole inhib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
4fx3
Crystal structure of the cdk2/cyclin a complex with oxindole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high-five. Gene: ccn1, ccna, ccna2, cyclin a.
Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10
4g6l
Crystal structure of human cdk8/cycc in the dmg-in conformat
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.
Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10
4gcj
Cdk2 in complex with inhibitor rc-3-89
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (304 residues) CATH domains: 3.30.200.20 1.10.510.10
4i3z
Structure of pcdk2/cyclina bound to adp and 2 magnesium ions
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 511693. Mus musculus. Mouse. Organism_taxid: 10090.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
4ii5
Structure of pcdk2/cyclina bound to adp and 1 magnesium ion
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 511693. Mus musculus. Mouse. Organism_taxid: 10090.
Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
4imy
The aff4 scaffold binds human p-tefb adjacent to HIV tat
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Gene: aff4, af5q31, mcef, hspc092. Expressed in: escherichia coli.
Chains: A, C, E (315 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ADP
4kd1
Cdk2 in complex with dinaciclib
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
4krc
Crystal structure of pho85-pcl10-atp-gamma-s complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: p7102.18a, pho85, ssg3, ypl031c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: g2838, pcl10, ygl134w.
Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AGS is 93.75% similar to enzyme reactant ATP
4krd
Crystal structure of pho85-pcl10 complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: p7102.18a, pho85, ssg3, ypl031c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: g2838, pcl10, ygl134w.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
4lyn
Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) com (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)- thiazol-2-yl)-2-phenylpropanamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
4nj3
Modulating the interaction between cdk2 and cyclin a with a based inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
4nst
Crystal structure of human cdk12/cyclin k in complex with ad fluoride
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk12, crk7, crkrs, kiaa0904. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnk, cpr4.
Chains: A, C (323 residues) CATH domains: 3.30.200.20 1.10.510.10
4ogr
Crystal structure of p-tefb complex with aff4 and tat
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Gene: aff4, af5q31, mcef, hspc092. Expressed in: escherichia coli.
Chains: A, E, I (315 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADN is 70.37% similar to enzyme product ADP
4or5
Crystal structure of HIV-1 tat complexed with human p-tefb a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Gene: ccnt1. HIV-1. Organism_taxid: 11706. Strain: isolate hxb2. Gene: tat.
Chains: A, F (320 residues) CATH domains: 3.30.200.20 1.10.510.10
4p41
Crystal structure of a cdk6/vcyclin complex with inhibitor b
Source: Saimiriine herpesvirus 2. Sahv-2. Organism_taxid: 10383. Strain: 11. Gene: 72, eclf2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Homo sapiens. Human.
Chain: B (256 residues) CATH domains: 3.30.200.20 1.10.510.10
4tth
Crystal structure of a cdk6/vcyclin complex with inhibitor b
Source: Saimiriine herpesvirus 2. Sahv-2. Organism_taxid: 10383. Strain: 11. Gene: 72, eclf2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Homo sapiens. Human.
Chain: B (256 residues)
4un0
Crystal structure of the human cdk12-cyclink complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: C, D (309 residues) CATH domains: 3.30.200.20 1.10.510.10