_EC 2.7.11.21 Polo kinase. 71 PDB entries  
EC 2.-.-.- Transferases. [17,943 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,910 PDB entries]
EC 2.7.11.- Protein-serine/threonine kinases. [2,975 PDB entries]
EC 2.7.11.21 Polo kinase. [71 PDB entries]    
1mby

Reaction: Atp + a protein = adp + a phosphoprotein.
 


ATP
+
protein
=
ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Plk. Polo serine-threonine kinase. Polo-like kinase.
Comments: The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. Formerly Ec 2.7.1.37.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 71 PDB entries in enzyme class E.C.2.7.11.21

  PDB code Protein
1mby
Murine sak polo domain
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: sak. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (75 residues) CATH domain: Unassigned
1q4k
The polo-box domain of plk1 in complex with a phospho- peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemical synthesis
Chains: B, A, C (224 residues) CATH domains: 3.30.1120.30 3.30.1120.30
1q4o
The structure of the polo box domain of human plk1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk or plk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (207 residues) CATH domains: 3.30.1120.30 3.30.1120.30
1umw
Structure of a human plk1 polo-box domain/phosphopeptide complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B (223 residues) CATH domains: 3.30.1120.30 3.30.1120.30
2ogq
Molecular and structural basis of plk1 substrate recognition: implications in centrosomal localization
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (211 residues) CATH domains: 3.30.1120.30 3.30.1120.30
2ojs
Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in centrosomal localization
Source: Homo sapiens. Human. Gene: plk1, plk. Expressed in: escherichia coli. Synthetic: yes
Chain: A (227 residues) CATH domains: 3.30.1120.30 3.30.1120.30
2ojx
Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in centrosomal localization
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Chain: A (204 residues) CATH domains: 3.30.1120.30 3.30.1120.30
2ou7
Structure of the catalytic domain of human polo-like kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
2owb
Structure of the catalytic domain of human polo-like kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
2rku
Structure of plk1 in complex with bi2536
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
2v5q
Crystal structure of wild-type plk-1 kinase domain in complex with a selective darpin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Unidentified. Organism_taxid: 32644. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (285 residues) CATH domains: 3.30.200.20 1.10.510.10
2yac
Crystal structure of polo-like kinase 1 in complex with nms-
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: highfive.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
3bzi
Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in centrosomal localization
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Chain: A (223 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3c5l
Polo-like kinase 1 polo box domain in complex with pphspt peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (217 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3cok
Crystal structure of plk4 kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk4, sak, stk18. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (234 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 92.00% similar to enzyme product ADP
3d5u
Crystal structure of a wildtype polo-like kinase 1 (plk1) catalytic domain.
Source: Danio rerio. Leopard danio,zebra danio,zebra fish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
3d5v
Crystal structure of an activated (thr->asp) polo-like kinase 1 (plk1) catalytic domain.
Source: Danio rerio. Leopard danio,zebra danio,zebra fish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (260 residues) CATH domains: 3.30.200.20 1.10.510.10
3d5w
Crystal structure of a phosphorylated polo-like kinase 1 (plk1) catalytic domain in complex with adp.
Source: Danio rerio. Leopard danio,zebra danio,zebra fish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
3d5x
Crystal structure of an activated (thr->asp) polo-like kinase 1 (plk1) catalytic domain in complex with wortmannin.
Source: Danio rerio. Leopard danio,zebra danio,zebra fish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
3db6
Crystal structure of an activated (thr->asp) polo-like kinase 1 (plk1) catalytic domain in complex with compound 902
Source: Danio rerio. Zebra fish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
3db8
Crystal structure of an activated (thr->asp) polo-like kinase 1 (plk1) catalytic domain in complex with compound 041
Source: Danio rerio. Zebra fish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli.
Chain: A (261 residues) CATH domains: 3.30.200.20 1.10.510.10
3dbc
Crystal structure of an activated (thr->asp) polo-like kinase 1 (plk1) catalytic domain in complex with compound 257
Source: Danio rerio. Zebrafish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli.
Chain: A (261 residues) CATH domains: 3.30.200.20 1.10.510.10
3dbd
Crystal structure of an activated (thr->asp) polo-like kinase 1 (plk1) catalytic domain in complex with compound 094
Source: Danio rerio. Zebrafish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli.
Chain: A (261 residues) CATH domains: 3.30.200.20 1.10.510.10
3dbe
Crystal structure of an activated (thr->asp) polo-like kinase 1 (plk1) catalytic domain in complex with compound 557
Source: Danio rerio. Zebrafish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli.
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
3dbf
Crystal structure of an activated (thr->asp) polo-like kinase 1 (plk1) catalytic domain in complex with compound 562
Source: Danio rerio. Zebrafish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli.
Chain: A (261 residues) CATH domains: 3.30.200.20 1.10.510.10
3fc2
Plk1 in complex with bi6727
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
3fvh
Polo-like kinase 1 polo box domain in complex with ac-lhspta peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk, plk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized
Chain: A (233 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3hih
Structure of human plk1-pbd with glycerol and sulfate in the phophopeptide binding site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk, plk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (223 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3hik
Structure of human plk1-pbd in complex with plhspt
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk, plk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (224 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3kb7
Crystal structure of polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: h5.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
3mhn
Human plk1-pbd in complex with poloxime ((e)-4-(hydroxyimino isopropyl-5-methylcyclohexa-2,5-dienone)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (222 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3mhq
Human plk1-pbd with a glycerol bound at the phophopeptide bi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (222 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3mq8
Human plk1-pbd in complex with thymoquinone at the phophopep binding site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (220 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3p2w
Unliganded form of polo-like kinase i polo-box domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (219 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3p2z
Polo-like kinase i polo-box domain in complex with plhspta phosphopeptide from pbip1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
Chain: A (210 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3p34
Polo-like kinase i polo-box domain in complex with mqsptpl phosphopeptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
Chain: A (230 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3p35
Polo-like kinase i polo-box domain in complex with mqspspl phosphopeptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
Chains: A, B, C (217 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3p36
Polo-like kinase i polo-box domain in complex with dpplhspta phosphopeptide from pbip1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
Chain: A (217 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3p37
Polo-like kinase i polo-box domain in complex with fdpplhspt phosphopeptide from pbip1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized
Chains: A, B, C (224 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3q1i
Polo-like kinase i polo-box domain in complex with fmpppmsps phosphopeptide from tcerg1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic phosphopeptide
Chain: A (216 residues) CATH domains: 3.30.1120.30 3.30.1120.30
3rq7
Polo-like kinase 1 polo box domain in complex with a c6h5(ch derivatized peptide inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (212 residues) CATH domains: 3.30.1120.30 3.30.1120.30
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
3thb
Structure of plk1 kinase domain in complex with a benzolacta inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
4a4l
Crystal structure of polo-like kinase 1 in complex with a 5-(2-amino-pyrimidin-4-yl)-1h-pyrrole inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: highfive.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
4a4o
Crystal structure of polo-like kinase 1 in complex with a 2- (2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolopyridin- 4-one inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: highfive.
Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10
4b6l
Discovery of oral polo-like kinase (plk) inhibitors with enh selectivity profile using residue targeted drug design
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
4dfw
Oxime-based post solid-phase peptide diversification: identi of high affinity polo-like kinase 1 (plk1) polo-box domain peptides
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk, plk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (219 residues) CATH domains: 3.30.1120.30 3.30.1120.30
4e67
The structure of the polo-box domain (pbd) of polo-like kina (plk1) in complex with hydrocinnamoyl-derivatized plhspta p
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid-state peptide synthesis
Chain: A (213 residues) CATH domains: 3.30.1120.30 3.30.1120.30
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4e9c
The structure of the polo-box domain (pbd) of polo-like kina (plk1) in complex with ldpplhspta phosphopeptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid phase peptide synthesis
Chain: A (223 residues) CATH domains: 3.30.1120.30 3.30.1120.30
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4e9d
The structure of the polo-box domain (pbd) of polo-like kina (plk1) in complex with 3-(1-benzothiophen-2-yl)propanoyl-de dpplhspta peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid phase peptide synthesis
Chain: A (222 residues) CATH domains: 3.30.1120.30 3.30.1120.30
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4g7n
The structure of the plk4 cryptic polo box reveals two tande boxes required for centriole duplication
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: cg7186, plk4, sak. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (218 residues) CATH domains: Unassigned Unassigned
4h5x
Human plk1-pbd with a glycerol bound at the phophopeptide bi
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (218 residues) CATH domains: 3.30.1120.30 3.30.1120.30
4h70
Human plk1-pbd in complex with thymoquinone at the phophopep binding site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (220 residues) CATH domains: 3.30.1120.30 3.30.1120.30
4h71
Human plk1-pbd in complex with poloxime ((e)-4-(hydroxyimino isopropyl-5-methylcyclohexa-2,5-dienone)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (216 residues) CATH domains: 3.30.1120.30 3.30.1120.30
4hab
Crystal structure of plk1 polo-box domain in complex with pl
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk, plk1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide pl-49
Chains: A, B, C (223 residues) CATH domains: 3.30.1120.30 3.30.1120.30
Bound ligand:   Het Group 11Q is 50.00% similar to enzyme reactant protein
4hco
Human plk1-pbd in complex with thymoquinone at the phophopep binding site
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (220 residues) CATH domains: 3.30.1120.30 3.30.1120.30
4hy2
Crystal structure of plk1 polo-box domain in complex with pl
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk, plk1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide pl-42
Chain: A (215 residues) CATH domains: 3.30.1120.30 3.30.1120.30
4i5m
Selective & brain-permeable polo-like kinase-2 (plk-2) inhib reduce -synuclein phosphorylation in rat brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk2, snk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
4i5p
Selective & brain-permeable polo-like kinase-2 (plk-2) inhib reduce -synuclein phosphorylation in rat brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk2, snk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
4i6b
Selective & brain-permeable polo-like kinase-2 (plk-2) inhib reduce -synuclein phosphorylation in rat brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk2, snk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group 11G is 43.75% similar to enzyme product ADP
4i6f
Selective & brain-permeable polo-like kinase-2 (plk-2) inhib reduce -synuclein phosphorylation in rat brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk2, snk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
4i6h
Selective & brain-permeable polo-like kinase-2 (plk-2) inhib reduce alpha-synuclein phosphorylation in rat brain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk2, snk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
4j52
Crystal structure of plk1 in complex with a pyrimidodiazepin inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
4j53
Crystal structure of plk1 in complex with tak-960
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
4j7b
Crystal structure of polo-like kinase 1
Source: Danio rerio. Leopard danio,zebra danio,zebra fish. Organism_taxid: 7955. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Drosophila melanogaster. Fruit fly. Organism_taxid: 7227.
Chains: A, B, D, E (284 residues) CATH domains: 3.30.200.20 1.10.510.10
4jxf
Crystal structure of plk4 kinase with an inhibitor: 400631 ( {3-[(e)-2-{4-[(dimethylamino)methyl]phenyl}ethenyl]-2h-inda 5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'h)-one)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk4, sak, stk18. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (235 residues) CATH domains: 3.30.200.20 1.10.510.10
4lkl
Crystal structure of plk1 polo-box domain in complex with pl
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid phase synthesis
Chain: A (214 residues) CATH domains: 3.30.1120.30 3.30.1120.30
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4lkm
Crystal structure of plk1 polo-box domain in complex with pl
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: solid phase synthesis
Chains: A, C (226 residues) CATH domains: 3.30.1120.30 3.30.1120.30
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4mlu
Peptides containing mono-anionic phosphothreonine esters tha high plk1 polo-box domain-binding affinities and potent antiproliferative effects in hela cells
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk1, plk. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chain: A (216 residues) CATH domains: 3.30.1120.30 3.30.1120.30
Bound ligand:   Het Group PRO is 50.00% similar to enzyme reactant protein
4n7v
Crystal structure of human plk4 cryptic polo box (cpb) in co a cep152 n-terminal fragment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk4, sak, stk18. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cep152, kiaa0912. Expression_system_taxid: 562
Chains: A, B (222 residues) CATH domains: Unassigned Unassigned
4n7z
Crystal structure of human plk4 cryptic polo box (cpb) in co a cep192 n-terminal fragment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk4, sak, stk18. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cep192. Expression_system_taxid: 562
Chain: A (219 residues) CATH domains: Unassigned Unassigned
4n9j
Crystal structure of the cryptic polo box domain of human pl
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plk4, sak, stk18. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (222 residues) CATH domains: Unassigned Unassigned